Abstracts tagged "lupus nephritis and rheumatic disease"

Abstract Number: 2587 • 2017 ACR/ARHP Annual Meeting
KZR-616, a Selective Inhibitor of the Immunoproteasome, Shows a Promising Safety and Target Inhibition Profile in a Phase I, Double-Blind, Single (SAD) and Multiple Ascending Dose (MAD) Study in Healthy Volunteers
Jason Lickliter¹, Janet Anderl², Christopher J Kirk³, Jinhai Wang⁴ and Darrin Bomba⁵, ¹Nucleus Network, Melbourne, Australia, ²Biology, Kezar Life Sciences, South San Francisco, CA, ³Kezar Life Sciences, South San Francisco, CA, ⁴DMPK, Kezar Life Sciences, South San Francisco, CA, ⁵Clinical Operations, Kezar Life Sciences, South San Francisco, CA
Background/Purpose: Proteasome inhibition is a standard of care for plasma cell malignancies. The first-generation inhibitor, bortezomib (BTZ), targets the constitutive proteasome and immunoproteasome and has…

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Abstracts tagged "lupus nephritis and rheumatic disease"

KZR-616, a Selective Inhibitor of the Immunoproteasome, Shows a Promising Safety and Target Inhibition Profile in a Phase I, Double-Blind, Single (SAD) and Multiple Ascending Dose (MAD) Study in Healthy Volunteers