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Abstracts tagged "lupus nephritis and renal disease"

  • Abstract Number: 2948 • ACR/ARHP Annual Meeting 2018

    Deconstructing the in Situ Myeloid Cell Microenvironment in Human Lupus Nephritis Tissue

    Paul Hoover1,2, Tony Jones2, Cianna Leatherwood3, Sushrut Waikar4, Karen Costenbader3 and Nir Hacohen5, 1Division of Rheumatology, Allergy, Immunology, Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Cambridge, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 4Renal, Brigham and Women's Hospital, Boston, MA, 5Harvard Medical School, Boston, MA

    Background/Purpose: The cell-types and pathways driving lupus nephritis (LN) are incompletely understood. The Accelerating Medicine Partnership lupus network Pathway Exploration and Analysis in RenaL disease…
  • Abstract Number: 724 • ACR/ARHP Annual Meeting 2018

    Are Traditional Biomarkers of Lupus Associated with Renal Pathology in Lupus Nephritis?

    Kelly Liang1, Kimberly P. Liang2, Yaming Li3, Alex Hurd3, Douglas Landsittel4 and Sheldon Bastacky5, 1Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, 2Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 3Biostatistics, University of Pittsburgh, Pittsburgh, PA, 4Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, 5Pathology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Traditional biomarkers for systemic lupus erythematosus (SLE) and lupus nephritis (LN) include serum creatinine (Cr), complement levels (C3/C4), double-stranded DNA antibody (dsDNA), erythrocyte sedimentation…
  • Abstract Number: 774 • ACR/ARHP Annual Meeting 2018

    Clinical Variables and Serologic Markers of Disease Activity Do Not Aid in Early Recognition of Patients with Tubulointerstitial Disease Who Have No Significant Renal Impairment at Time of Biopsy

    Alejandra Londono Jimenez1, Beatrice Goilav2, Maria Salgado Guerrero3, Kimberly A. Lynch4, Wenzhu B. Mowrey2 and Anna R. Broder5, 1Rheumatology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Internal Medicine, Jacobi Medical Center, Bronx, NY, 4Internal Medicine, Montefiore Medical Center, Bronx, NY, 5Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY

    Background/Purpose: Tubulointerstitial damage (TID), defined as tubulointerstitial inflammation (TII) or interstitial fibrosis/tubular atrophy/ (IF/TA) is associated with poor renal outcomes in lupus nephritis (LN)1. Glomerular…
  • Abstract Number: 9 • ACR/ARHP Annual Meeting 2017

    Renal Protective Effect of Antiplatelet Therapy in Antiphospholipid Antibody-Positive Lupus Nephritis Patients without the Antiphospholipid Syndrome

    Hironari Hanaoka1, Tomofumi Kiyokawa1, Harunobu Iida1, Yukiko Takakuwa1, Takahiro Okazaki2, Hidehiro Yamada3, Shoichi Ozaki4 and Kimito Kawahata1, 1Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 2Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 3Rheumatology, Seirei Yokohama Hospital, Yokohama, Japan, 4Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Lupus nephritis (LN) class III or IV is associated with a poor prognosis for both patient and renal survival. Since antiphospholipid syndrome (APS) is…
  • Abstract Number: 2838 • ACR/ARHP Annual Meeting 2016

    Histopatholgic Predictors of Poor Renal Outcomes in a Multi-Ethnic Cohort

    Stacy Tanner1, Dominick Santoriello2, Shanthi Dhaduvai3, Thania Perez4, Anca D. Askanase5 and Laura Geraldino-Pardilla6, 1Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 2Renal Pathology, Columbia University College of Physicians & Surgeons, New York, NY, 3Rheumatology, Carilion Clinic, Roanoke, VA, 4Columbia University College of Physicians & Surgeons, New York, NY, 5Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 6Columbia University College of Physicians & Surgeons, new york, NY

    Background/Purpose: Lupus nephritis (LN) remains an important cause of morbidity and mortality in patients with SLE.  Tubular atrophy and interstitial fibrosis on initial renal biopsies…

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