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Abstracts tagged "lupus nephritis and mycophenolate mofetil"

  • Abstract Number: 939 • ACR/ARP Annual Meeting 2019

    A Phase II Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Obinutuzumab or Placebo in Combination with Mycophenolate Mofetil in Patients with Active Class III or IV Lupus Nephritis

    Richard Furie1, Gustavo Aroca 2, Analía Alvarez 3, Hilda Fragoso-Loyo 4, Elizabeth Zuta Santillán 5, Brad Rovin 6, Thomas Schindler 7, Imran Hassan 8, Matthew Cascino 9, Jay P. Garg 10 and Ana Malvar 11, 1Northwell Health, Great Neck, NY, 2Simon Bolivar University y Clinica de la Costa, Barranquilla, Colombia, 3CEMIC, Buenos Aires, Argentina, 4Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, 5Instituto de Ginecología y Reproducción, Lima, Peru, 6The Ohio State University Medical Center, Columbus, OH, 7F. Hoffmann-La Roche AG, Basel, Switzerland, 8Hoffmann-La Roche Ltd, Mississauga, ON, Canada, 9Genentech, Inc., San Fransisco, CA, 10Genentech, Inc., South San Francisco, CA, 11Hospital Fernandez; Organización Maedica de Investigación, Buenos Aires, Argentina

    Background/Purpose: Randomized trials in lupus nephritis (LN) of type I anti-CD20 monoclonal antibodies failed to demonstrate superiority over standard of care alone. NOBILITY (NCT02550652) is…
  • Abstract Number: 2647 • ACR/ARHP Annual Meeting 2018

    Comparison of Low-Dose Intravenous Cyclophosphamide with Oral Mycophenolate Mofetil in the Treatment of Lupus Nephritis: Long Term Follow-up Data

    Manish Rathi1, Aman Sharma2, Joyita Sharma3 and Krishan L Gupta3, 1Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Clinical Immunology and Rheumatology Services, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, Chandigarh, India, 3Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarrh, India

    Background/Purpose: We present the long-term follow-up of patients with lupus nephritis who completed the randomized controlled trial on comparison of low-dose intravenous cyclophosphamide (IV CYC)…
  • Abstract Number: 766 • ACR/ARHP Annual Meeting 2016

    Withdrawal of Mycophenolate Mofetil after Maintenance Treatment of SLE Nephritis Associated with Renal Relapse

    H. Michael Belmont1 and Adey Berhanu2, 1New York University School of Medicine, New York, NY, 2Rheumatology Fellowship Program, NYU Langone Medical Center/NYU School of Medicine, New York, NY

    Background/Purpose: Current ACR and EULAR evidence based guidelines provide recommendations for therapeutic choices to induce and maintain remission of lupus nephritis, however, the appropriate duration…
  • Abstract Number: 2941 • ACR/ARHP Annual Meeting 2015

    Outcomes in Lupus Nephritis Patients Previously Randomized to Receive Either Low Dose Cyclophosphamide Versus Oral Mycophenolate Mofetil on Azathioprine Maintenance

    Manish Rathi1, Ajay Jaryal2, Ajay Goyal2, Aman Sharma3, Pramod Gupta4 and Krishan Gupta2, 1Department of Nephrology,, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 2Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 4Biostatistics, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Background/Purpose: Management of SLE and lupus nephritis is challenging as it is always a trade off between remission, prevention of relapse and long term adverse…
  • Abstract Number: 958 • ACR/ARHP Annual Meeting 2014

    The 10-Year Followup of a Trial Comparing Azathioprine and Mycophenolate Mofetil for Long-term Immunosuppression of Lupus Nephritis

    Farah Tamirou1, David D'Cruz2, Shirish Sangle3, Philippe Remy4, Carlos Vasconcelos5, Christoph Fiehn6, Maria del Mar Ayala Gutierrez7, Inge-Margrethe Gilboe8, Maria Tektonidou9, Daniel Blockmans10, Isabelle Ravelingien11, Véronique le Guern12, Geneviève Depresseux1, Loïc Guillevin13, Ricard Cervera14 and Frédéric A. Houssiau15, 1Pôle de Pathologies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Bruxelles, Belgium, 2Rheumatology, Louis Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 3Lupus Unit, St Thomas' Hospital, London, United Kingdom, 4Service de Néphrologie et de Transplantation, Hôpital Henri Mondor, Créteil, France, 5Imunologia Clinica - M Interna, Hospital Geral Santo Antonio, Porto, Portugal, 6ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany, 7General Internal Medicine, Hospital Regional Universitario Carlos Haya, Malaga, Spain, Malaga, Spain, 8Rheumatology unit, Oslo University Hospital Rikshospitalet, Oslo, Norway, 9First Department of Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, 10Rheumatology, UZ Leuven, Leuven, Belgium, 11Rheumatology, Onze-Lieve-Vrouwzienkenhuis, Aalst, Belgium, 12Internal Medicine, Hôpital Cochin, Paris, France, 13Internal Medicine, Hôpital Cochin, University Paris V Descartes, Paris, France, 14Autoimmune Diseases, Hospital Clínic of Barcelona, Barcelona, Spain, 15Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose Very longterm data are rarely reported in lupus nephritis (LN) trials, despite their pivotal importance to detect late poor renal outcomers and to identify…

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