Abstracts tagged "lupus nephritis and mouse model"

Abstract Number: 2094 • 2018 ACR/ARHP Annual Meeting
Examining T Cell Exhaustion in Murine Systemic Lupus Erythematosus
Jeremy Tilstra¹, Lyndsay Avery², Ashley Menk², Rachael Gordon², Shuchi Smita³, Lawrence Kane³, Maria Chikina², Greg Delgoffe³ and Mark Shlomchik⁴, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, little is known about how T cells function…
Abstract Number: 2104 • 2018 ACR/ARHP Annual Meeting
Glomerular and Tubular Transcriptional Profiles Reveal Gene Clusters Specific for Different Stages of Glomerulonephritis in NZM2328 Mice
Hongyang Wang¹, Nick Geraci², Prathyusha Bachali², Brian Kegerreis³, Michelle Catalina², Erika Hubbard², Sun-sang Sung⁴, Felicia Gaskin⁵, Amrie Grammer², Peter Lipsky² and Shu Man Fu⁶, ¹Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ²AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ³AMPELBioSolutions and RILITE Research Institute, Charlottesville, VA, ⁴Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁵Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁶Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: NZM2328 mice spontaneously develop glomerulonephritis (GN) and females commonly progress to renal failure. Our previous study showed that acute GN (aGN) and chronic GN…
Abstract Number: 2839 • 2014 ACR/ARHP Annual Meeting
BCL-2 As a Potential Therapeutic Target in Human Lupus Tubulointerstitial Inflammation
Kichul Ko¹, Denisse Yanez¹, Natalya Kaverina¹, Vladimir M. Liarski¹, Yahui Peng², Li Lan³, Stuart Perper⁴, Annette Schwartz⁵, Liz O'connor⁶, Andrew Souers⁷, Steven Elmore⁷, Lisa Olson⁵, Maryellen L. Giger³, Li Chun Wang⁴ and Marcus R. Clark¹, ¹Rheumatology and Knapp Center for Lupus Research, University of Chicago, Chicago, IL, ²School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China, ³Radiology, University of Chicago, Chicago, IL, ⁴Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁶Toxicology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁷AbbVie Inc, North Chicago, IL
Background/Purpose Lupus nephritis (LuN) is the most common, severe manifestation of systemic lupus erythematosus (SLE). We have previously shown that glomerulonephritis appears to be a…
Abstract Number: 558 • 2013 ACR/ARHP Annual Meeting
Fli-1 Regulates Immune Cell Infiltration Through Affecting Local Chemokine Expression and IL-6 Expression In The Kidney Of Lupus Prone Mice
Shuzo Sato¹, Sarah Williams², Eva Karam³ and Xian Zhang⁴, ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Ralph H. Johnson VA Medical Center, Charleston, SC, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: Fli-1 expression level, a member of the Ets family of transcription factors, is a mitigating factor in the development of nephritis in murine models…

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