Abstract Number: 1752 • ACR/ARHP Annual Meeting 2016
IL-23 Promotes the Generation of DNT Cells and Shifts the Balance Between IL-2 and IL-17 Production in Murine and Human SLE
Background/Purpose: MRL/lpr mice develop a chronic inflammatory disease characterized by accumulation of CD4-CD8-B220+T cells mimicking human lupus; IL-23 driven IL-17 producing cell contribute to lupus…Abstract Number: 1753 • ACR/ARHP Annual Meeting 2016
Signal Transducer and Activator of Transcription (STAT) 3 Regulates Tcrαβ+CD4-CD8- T Cells in Systemic Lupus Erythematosus (SLE)
Background/Purpose: TCRαβ+CD4-CD8-T cells (double negative T cells, DNT) have been reported to produce inflammatory cytokines such as IL-17, and infiltrate the kidneys of patients with…Abstract Number: 3031 • ACR/ARHP Annual Meeting 2015
Dalazatide (ShK-186), a Kv1.3 Channel Inhibitor That Targets Effector Memory T Cells: Ex Vivo Studies in Pediatric Systemic Lupus Erythematosus
Background/Purpose: The voltage-gated potassium channel Kv1.3 is highly expressed on activated T effector memory cells (TEM), is essential for T cell activation, and thus is…Abstract Number: 2688 • ACR/ARHP Annual Meeting 2014
Comparison of Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive African-Americans Reveals Distinct Differences in T Cell and Progenitor Populations
Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder which arises from both genetic and environmental factors that likely affect phenotypic and functional characteristics…
ACR Meeting Abstracts