Abstracts tagged "Lupus and T cells"

Abstract Number: 1752 • 2016 ACR/ARHP Annual Meeting
IL-23 Promotes the Generation of DNT Cells and Shifts the Balance Between IL-2 and IL-17 Production in Murine and Human SLE
Hong Dai^1,2, Fan He^1,2, George C. Tsokos^1,2 and Vasileios C. Kyttaris^1,2, ¹Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ²Harvard Medical School, Boston, MA
Background/Purpose: MRL/lpr mice develop a chronic inflammatory disease characterized by accumulation of CD4-CD8-B220+T cells mimicking human lupus; IL-23 driven IL-17 producing cell contribute to lupus…
Abstract Number: 1753 • 2016 ACR/ARHP Annual Meeting
Signal Transducer and Activator of Transcription (STAT) 3 Regulates Tcrαβ+CD4-CD8- T Cells in Systemic Lupus Erythematosus (SLE)
Fan He^1,2, Hao Li^1,2, George C. Tsokos^1,2 and Vasileios C. Kyttaris^1,2, ¹Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ²Harvard Medical School, Boston, MA
Background/Purpose: TCRαβ+CD4-CD8-T cells (double negative T cells, DNT) have been reported to produce inflammatory cytokines such as IL-17, and infiltrate the kidneys of patients with…
Abstract Number: 3031 • 2015 ACR/ARHP Annual Meeting
Dalazatide (ShK-186), a Kv1.3 Channel Inhibitor That Targets Effector Memory T Cells: Ex Vivo Studies in Pediatric Systemic Lupus Erythematosus
Megan Yuasa¹, David Peckham², Anne M. Stevens³, Shawn P. Iadonato² and Ernesto J. Muñoz-Elías⁴, ¹Seattle Children's Res Institute, Seattle Children's Research Institute, Seattle, WA, ²Kineta Inc, Seattle, WA, ³Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ⁴Translational Immunology & Preclinical Development, Kineta, Inc., Seattle, WA
Background/Purpose: The voltage-gated potassium channel Kv1.3 is highly expressed on activated T effector memory cells (TEM), is essential for T cell activation, and thus is…
Abstract Number: 2688 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive African-Americans Reveals Distinct Differences in T Cell and Progenitor Populations
Rufei Lu^1,2, Samantha Slight-Webb¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James^5,6, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder which arises from both genetic and environmental factors that likely affect phenotypic and functional characteristics…

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