Abstracts tagged "Lupus and pharmacokinetics"

Abstract Number: 2607 • ACR/ARHP Annual Meeting 2017
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of BIIB059, a Monoclonal Antibody Targeting BDCA2 Following Administration of Intravenous and Subcutaneous Single or Multiple Doses in Healthy Volounters and Subjects with Active SLE
Himanshu Naik¹, Cristina Musselli¹, Catherine Barbey², Romy B. Christmann¹, Lauren Stevenson¹, Dania Rabah¹, Parul Gulati¹ and Nathalie Franchimont¹, ¹Biogen, Cambridge, MA, ²Biogen, Zug, Switzerland
Background/Purpose: BDCA2 is a plasmacytoid dendritic cell (pDC)-specific receptor that, upon activation, inhibits the production of inflammatory factors by human pDCs, including IFN-α a major…