ACR Meeting Abstracts

ACR Meeting Abstracts

Abstracts tagged "Lupus and genetics"

  • Abstract Number: 2657 • ACR/ARHP Annual Meeting 2017

    Single Cell Expression Quantitative Trait Loci (eQTL) Analysis of Established Systemic Lupus Erythematosus (SLE)-Risk Loci in Lupus Patient Monocytes

    Yogita Ghodke-Puranik1, Zhongbo Jin2, Wei Fan3, Mark A. Jensen1, Jessica M. Dorschner2, Danielle Vsetecka2, Shreyasee Amin4, Ashima Makol5, Floranne C. Ernste6, Thomas Osborn4, Kevin Moder4, Vaidehi Chowdhary7 and Timothy Niewold8, 1Colton Center for Autoimmunity, New York University, New York, NY, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, 4Rheumatology, Mayo Clinic, Rochester, MN, 5Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 6Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, 7Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 8New York University, New York, NY

    Background/Purpose: Most confirmed SLE-risk loci are found near or in genes with immune function, yet how these loci influence diverse immune cell subsets remains unknown.…

  • Abstract Number: 1837 • ACR/ARHP Annual Meeting 2016

    Genetic Susceptibility Loci for Systemic Lupus Erythematosus in the Dominican Republic Population

    Esthela Loyo1, Zheng Liu2, Carmen Tineo3, Paola Gottschalk3, Glenny Paulino3, Yangsheng Yu2, Yinshi Yue2, Michelene Hearth-Holmes4, Zhixin Zhang5 and Kaihong Su2, 1Departamento de Reumatologia, Hospital Regional Universitario Jose Maria Cabral y Baez, Santiago, Dominican Republic, 2Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 3Division of Rheumatology, Hospital Regional Universitario José Ma Cabral Baez, Santiego, Dominican Republic, 4Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE, 5Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with marked disparities in prevalence and disease characteristics among different populations. Those disparities are believed…

  • Abstract Number: 1869 • ACR/ARHP Annual Meeting 2015

    Association of CLEC16A with SLE in a Large Multi-Ancestry Cohort and Implication in B-Cell Receptor Signaling

    Isaac TW Harley1,2,3, Samuel Vaughn4, Adrienne H. Williams5, Julie T. Ziegler6, Mary Comeau7, Miranda Marion8, Stuart Glenn9, Adam Adler10, Kenneth M. Kaufman11, Sang-Cheol Bae12, Carl D. Langefeld13, Jennifer Kelly14, Patrick M. Gaffney15, R. Hal Scofield16, Michelle Petri17, Jeffrey C. Edberg18, Joel M. Guthridge15, Susan A. Boackle19, Barry Freedman20, Diane L. Kamen21, Elizabeth E. Brown on behalf of PROFILE22, Gary S. Gilkeson23, John D. Reveille24, Joan T. Merrill25, Marta E. Alarcón-Riquelme26, Timothy Vyse27, Lindsey A. Criswell28, Rosalind Ramsey-Goldman29, Juan-Manuel Anaya30, Betty P. Tsao31, Judith A. James32, Graciela S. Alarcón33, Anne M. Stevens34, Kathy Moser Sivils15, Robert P. Kimberly35, Luis M. Vilá36, Chaim O. Jacob37, Bahram Namjou38, Leah C. Kottyan39, Timothy B. Niewold40 and John B. Harley11,41, 1Division of Internal Medicine, University of Colorado, Aurora, CO, 2Immunobiology Graduate Program and Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, 3Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, 6Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, 7Wake Forest University Health Sciences, Winston-Salem, NC, 8Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, NC, 9Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 10Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City,, OK, 11US Department of Veterans Affairs Medical Center, Cincinnati, OH, 12Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 13Wake Forest University, Wake Forest, NC, 14Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 16Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 17Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, 18Medicine/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 19Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 20Department of Internal Medicine, Wake Forest University Health Sciences, Wake Forest, NC, 21Medicine, Medical University of South Carolina, Charleston, SC, 22University of Alabama at Birmingham, Birmingham, AL, 23Department of Rheumatology, Medical University of South Carolina, Charleston, SC, 24Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 25Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 26Oklahoma Medical Research Foundation and Centro de Genómica e Investigación Oncológica Pfizer-Universidad de Granada-Junta de Andalucía (GENYO), Granada, Spain, Oklahoma City, OK, 27Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, 28Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 29Northwestern University Feinberg School of Medicine, Chicago, IL, 30Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, 31Medicine/Rheumatology, Division of Rheumatology, UCLA, Los Angeles, CA, 32Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, 33U of Alabama, Birmingham, AL, 34Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, 35Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 36Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, 37Medicine/Div of Rheumatology, USC School of Medicine, Los Angeles, CA, 38Oklahoma Medical Research Foundation, Edmond, OK, 393333 Burnet Ave., Ml 15012, Cincinnati, OH, 40Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 41Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Immune-mediated diseases appear to share a common genetic basis. Here we describe genetic association of single nucleotide polymorphisms (SNPs) within CLEC16A with SLE in…