Abstracts tagged "Lupus and genetics"

Abstract Number: 2657 • 2017 ACR/ARHP Annual Meeting
Single Cell Expression Quantitative Trait Loci (eQTL) Analysis of Established Systemic Lupus Erythematosus (SLE)-Risk Loci in Lupus Patient Monocytes
Yogita Ghodke-Puranik¹, Zhongbo Jin², Wei Fan³, Mark A. Jensen¹, Jessica M. Dorschner², Danielle Vsetecka², Shreyasee Amin⁴, Ashima Makol⁵, Floranne C. Ernste⁶, Thomas Osborn⁴, Kevin Moder⁴, Vaidehi Chowdhary⁷ and Timothy Niewold⁸, ¹Colton Center for Autoimmunity, New York University, New York, NY, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁶Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁷Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ⁸New York University, New York, NY
Background/Purpose: Most confirmed SLE-risk loci are found near or in genes with immune function, yet how these loci influence diverse immune cell subsets remains unknown.…
Abstract Number: 1837 • 2016 ACR/ARHP Annual Meeting
Genetic Susceptibility Loci for Systemic Lupus Erythematosus in the Dominican Republic Population
Esthela Loyo¹, Zheng Liu², Carmen Tineo³, Paola Gottschalk³, Glenny Paulino³, Yangsheng Yu², Yinshi Yue², Michelene Hearth-Holmes⁴, Zhixin Zhang⁵ and Kaihong Su², ¹Departamento de Reumatologia, Hospital Regional Universitario Jose Maria Cabral y Baez, Santiago, Dominican Republic, ²Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ³Division of Rheumatology, Hospital Regional Universitario José Ma Cabral Baez, Santiego, Dominican Republic, ⁴Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with marked disparities in prevalence and disease characteristics among different populations. Those disparities are believed…
Abstract Number: 1869 • 2015 ACR/ARHP Annual Meeting
Association of CLEC16A with SLE in a Large Multi-Ancestry Cohort and Implication in B-Cell Receptor Signaling
Isaac TW Harley^1,2,3, Samuel Vaughn⁴, Adrienne H. Williams⁵, Julie T. Ziegler⁶, Mary Comeau⁷, Miranda Marion⁸, Stuart Glenn⁹, Adam Adler¹⁰, Kenneth M. Kaufman¹¹, Sang-Cheol Bae¹², Carl D. Langefeld¹³, Jennifer Kelly¹⁴, Patrick M. Gaffney¹⁵, R. Hal Scofield¹⁶, Michelle Petri¹⁷, Jeffrey C. Edberg¹⁸, Joel M. Guthridge¹⁵, Susan A. Boackle¹⁹, Barry Freedman²⁰, Diane L. Kamen²¹, Elizabeth E. Brown on behalf of PROFILE²², Gary S. Gilkeson²³, John D. Reveille²⁴, Joan T. Merrill²⁵, Marta E. Alarcón-Riquelme²⁶, Timothy Vyse²⁷, Lindsey A. Criswell²⁸, Rosalind Ramsey-Goldman²⁹, Juan-Manuel Anaya³⁰, Betty P. Tsao³¹, Judith A. James³², Graciela S. Alarcón³³, Anne M. Stevens³⁴, Kathy Moser Sivils¹⁵, Robert P. Kimberly³⁵, Luis M. Vilá³⁶, Chaim O. Jacob³⁷, Bahram Namjou³⁸, Leah C. Kottyan³⁹, Timothy B. Niewold⁴⁰ and John B. Harley^11,41, ¹Division of Internal Medicine, University of Colorado, Aurora, CO, ²Immunobiology Graduate Program and Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ⁶Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, ⁷Wake Forest University Health Sciences, Winston-Salem, NC, ⁸Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, NC, ⁹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City,, OK, ¹¹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹³Wake Forest University, Wake Forest, NC, ¹⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ¹⁸Medicine/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²⁰Department of Internal Medicine, Wake Forest University Health Sciences, Wake Forest, NC, ²¹Medicine, Medical University of South Carolina, Charleston, SC, ²²University of Alabama at Birmingham, Birmingham, AL, ²³Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ²⁴Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²⁵Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁶Oklahoma Medical Research Foundation and Centro de Genómica e Investigación Oncológica Pfizer-Universidad de Granada-Junta de Andalucía (GENYO), Granada, Spain, Oklahoma City, OK, ²⁷Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ²⁸Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ²⁹Northwestern University Feinberg School of Medicine, Chicago, IL, ³⁰Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, ³¹Medicine/Rheumatology, Division of Rheumatology, UCLA, Los Angeles, CA, ³²Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, ³³U of Alabama, Birmingham, AL, ³⁴Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ³⁵Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³⁶Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ³⁷Medicine/Div of Rheumatology, USC School of Medicine, Los Angeles, CA, ³⁸Oklahoma Medical Research Foundation, Edmond, OK, ³⁹3333 Burnet Ave., Ml 15012, Cincinnati, OH, ⁴⁰Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Immune-mediated diseases appear to share a common genetic basis. Here we describe genetic association of single nucleotide polymorphisms (SNPs) within CLEC16A with SLE in…

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