ACR Meeting Abstracts
Abstract Number: 3005 • ACR/ARHP Annual Meeting 2014
Swati Bhattacharyya1,2, Wenxia Wang1, Luisa Morales-Nebreda3, Katja Lakota3, Robert Lafyatis4, Monique E. Hinchcliff5, GR Scott Budinger3, Zenshiro Tamaki3 and John Varga6, 1Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 3Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 4Rheumatology, Boston University School of Medicine, Boston, MA, 5Northwestern University, Feinberg School of Medicine, Chicago, IL, 6Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…