Abstracts tagged "lung injury and scleroderma"

Abstract Number: 3005 • 2014 ACR/ARHP Annual Meeting
Essential Role for Alternately Spliced Tenascin C and TLR4 Signaling in Persistent Organ Fibrosis
Swati Bhattacharyya^1,2, Wenxia Wang¹, Luisa Morales-Nebreda³, Katja Lakota³, Robert Lafyatis⁴, Monique E. Hinchcliff⁵, GR Scott Budinger³, Zenshiro Tamaki³ and John Varga⁶, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…

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