Abstracts tagged "Lung and rheumatoid arthritis (RA)"

Abstract Number: 522 • 2018 ACR/ARHP Annual Meeting
Analysis of Sequential Development of Pulmonary Lesions in Patients with Rheumatoid Arthritis
Ayae Tanaka¹, Kazuhiro Kurasawa¹, Yuta Takamura¹, Tomoyuki Miyao¹, Ryutaro Yamazaki², Satoko Arai¹, Takayoshi Owada¹, Reika Maezawa¹ and Masafumi Arima¹, ¹Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, ²Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan
Background/Purpose: We previously reported that there was patterns of coexistence of pulmonary lesions and airway disease (AD) were common abnormities of patients with pulmonary involvement.…
Abstract Number: 2901 • 2018 ACR/ARHP Annual Meeting
Sputum Neutrophils from Individuals at-Risk for RA Demonstrate Increased Citrullinated Histone H3 Containing Neutrophil Extracellular Traps That Correlate with Sputum Anti-Cyclic Citrullinated Peptide Antibody Levels
Yuko Okamoto¹, Nickie L. Seto², Mariana J. Kaplan², Ashley Visser¹, Jill M. Norris³, Kevin D. Deane¹, V. Michael Holers⁴ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ³Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Our group previously demonstrated that anti-citrullinated (cit) protein antibodies (ACPA) in the sputum correlate with remnants of neutrophil extracellular traps (NETs) in RA-free subjects…
Abstract Number: 484 • 2017 ACR/ARHP Annual Meeting
Sputum Neutrophils Demonstrate Increased Neutrophil Extracellular Trap Formation in RA-Free Subjects at-Risk of Future RA
Yuko Okamoto¹, Michael P. Mohning², Stacey M. Thomas², Ashley Visser¹, Lindsay B. Kelmenson³, Jill M. Norris⁴, Mariana J. Kaplan⁵, William J. Janssen², V. Michael Holers¹, Kevin D. Deane¹ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Pulmonary Disease and Critical Care Medicine, National Jewish Health, Denver, CO, ³Division of Rheumatoloty, University of Colorado School of Medicine, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD
Background/Purpose: Data support that ACPAs are generated in the lung in RA-free subjects At-Risk of future RA. Our group previously demonstrated a significant positive correlation…
Abstract Number: 586 • 2016 ACR/ARHP Annual Meeting
Association Between ACPA Fine Specificity and High Resolution Computed Tomography Lung Changes in Patients with Early Rheumatoid Arthritis
Vijay Joshua¹, Katerina Chatzidionysiou¹, Gudrun Reynisdottir¹, Aase Hensvold¹, Monika Hansson¹, Leonor Nogueira², Guy Serre², Johan Grunewald³ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, ³Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Airways abnormalities that are consistent with inflammation are common in anti-CCP2 positive subjects without inflammatory arthritis. Anti-CCP2 antibodies are associated with high-resolution computed tomography…
Abstract Number: 1559 • 2016 ACR/ARHP Annual Meeting
Shared Genetic Predisposition in Rheumatoid Arthritis–Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: A Genetic Association Study
Pierre-Antoine Juge¹, Raphaël Borie², Caroline Kannengiesser³, Steven Gazal³, Patrick Revy⁴, Lidwine Wemeau-Stervinou⁵, Marie-Pierre Debray⁶, Sébastien Ottaviani⁷, Sylvain Adam-Marchand⁸, Nadia Nathan⁹, Gabriel Thabut¹⁰, Christophe Richez¹¹, Hilario Nunes¹², Isabelle Callebaut¹³, Aurélien Justet², Nicolas Leulliot¹⁴, Amélie Bonnefond¹⁵, David Salgado¹⁶, Pascal Richette¹⁷, Jean-Pierre Desvignes¹⁶, Huguette Lioté¹⁸, Philippe Froguel¹⁵, Yannick Allanore¹⁹, Olivier Sand¹⁵, Claire Dromer²⁰, René-Marc Flipo²¹, Annick Clément⁹, Christophe Béroud²², Jean Sibilia²³, Baptiste Coustet^1,24, Vincent Cottin²⁵, Marie-Christophe Boissier²⁶, Benoit Wallaert²⁷, Thierry Schaeverbeke²⁸, Florence Dasto le Moal²⁹, Aline Frazier¹⁷, Christelle Ménard³⁰, Martin Soubrier³¹, Nathalie Saidenberg²⁹, Dominique Valeyre³², Serge Amselem⁹, Catherine Boileau³, Bruno Crestani² and Philippe Dieudé¹, ¹Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ²Pneumologie A, Hôpital Bichat - Claude Bernard, Paris, France, ³Génétique, Hôpital Bichat - Claude Bernard, Paris, France, ⁴Laboratory of Genome Dynamics in the Immune System, Institut Imagine, Paris, France, ⁵Pneumologie, CHRU de Lille, Lille, France, ⁶Université Paris-Diderot, Paris, France, ⁷Rheumatologie, Hôpital Bichat - Claude Bernard, Paris, France, ⁸Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, ⁹Pneumologie pédiatrique, Hôpital Trousseau, Paris, France, ¹⁰Pneumologie B, Hôpital Bichat - Claude Bernard, Paris, France, ¹¹Rhumatologie, Department of Rheumatology, Bordeaux University Hospital, Bordeaux, France, ¹²Pneumologie B, Hôpital Avicenne, Paris, France, ¹³CNRS UMR_7590, Paris, France, ¹⁴Laboratoire de cristallographie et RMN biologiques, UMR CNRS 8015, Paris, France, ¹⁵CNRS UMR_8199, Lille, France, ¹⁶UMR_S 910, Marseille, France, ¹⁷Rhumatologie, Hôpital Lariboisière, Paris, France, ¹⁸Pneumologie A, Hôpital Tenon, Paris, France, ¹⁹Rhumatologie A, Hôpital Cochin, Paris, France, ²⁰Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, ²¹Rhumatologie, CHU Lille, Lille, France, ²²INSERM UMR_S 910, Marseille, France, ²³Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁴Rheumatology, Université Paris Descartes, Hopital Cochin, Paris, France, ²⁵Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, ²⁶Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²⁷Pneumology, CHRU, Lille CEDEX, France, ²⁸Rheumatology, CHU Bordeaux, Bordeaux, France, ²⁹Rhumatologie, Hôpital Avicenne, Paris, France, ³⁰Pneumologie Pédiatrique, Hôpital Trousseau, Paris, France, ³¹Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ³²Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France
Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality for rheumatoid arthritis (RA) patients. Despite its high prevalence and mortality, little…
Abstract Number: 434 • 2014 ACR/ARHP Annual Meeting
Characterization of Lung Inflammation in the Lungs of Early Rheumatoid Arthritis
Gudrun Reynisdottir¹, Vijay Joshua², Aase Haj Hensvold², Lars Klareskog³ and Anca I Catrina², ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet,, Stockholm, Sweden, ²Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska institutet, Stockholm, Sweden
Background/Purpose We have previously demonstrated that lung abnormalities are present already at disease onset in ACPA positive RA patients. We aimed to further investigate lung…
Abstract Number: 810 • 2013 ACR/ARHP Annual Meeting
Inducible Bronchus Associated Lymphoid Tissue In The Lung Is Associated With Seropositivity For Rheumatoid Arthritis-Related Autoantibodies In Subjects With and Without Clinically Diagnosed Rheumatoid Arthritis
M. Kristen Demoruelle¹, Adam W. Bagley², Mark C. Parish¹, David E. Heinz³, V. Michael Holers⁴, Carlyne D. Cool⁵ and Kevin D. Deane¹, ¹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Internal Medicine, University of Colorado School of Medicine, Aurora, CO, ³Pathology, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁵University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Data suggest the lung may be a site of RA-related autoantibody (Ab) generation including findings of airways inflammation prior to onset of articular RA…
Abstract Number: 811 • 2013 ACR/ARHP Annual Meeting
Influence Of Smoking On Citrullinated Proteins and Porphyromonas Gingivalis In The Lung: A Priming Site For Autoimmunity In RA
Elena B. Lugli¹, Patrick Venables², Raquel Correia³, Karin Lundberg⁴, Ken Bracke⁵ and Guy Brusselle⁵, ¹University of Oxford, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ²Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ³Kennedy Institute of Rheumatology, Univerity of Oxford, Oxford, United Kingdom, ⁴Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Gent University, Gent, Belgium
Background/Purpose: Anti-citrullinated peptide/protein antibodies (ACPA) may be detected in RA serum more than 10 years before onset of disease, suggesting that the autoimmune response begins…
Abstract Number: 1236 • 2012 ACR/ARHP Annual Meeting
Important Prognostic Factor in Rheumatoid Arthritis Patients with Interstitial Lung Disease Is Not Usual Interstitial Pneumonia Pattern but Interstitial Lung Disease Extent On Chest High-Resolution Computed Tomography
Hwajeong Lee¹, Jung-Yoon Choe², Seong-Kyu Kim², Sung Hoon Park², Ji Hun Kim², Dae Sung Hyun³, Kyung Jae Jung⁴ and Jisuk Bae⁵, ¹Catholic University of Daegu School of Medicine, Daegu, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea, ³Division of Pulmonology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, South Korea, ⁴Radiology, Catholic University of Daegu School of Medicine, South Korea, ⁵Department of Preventive Medicine, Catholic University of Daegu School of Medicine, South Korea
Background/Purpose: Interstitial lung disease (ILD) is a common pulmonary manifestation of rheumatoid arthritis (RA), and an important cause of morbidity and mortality in RA patients.…
Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis
Elena B. Lugli¹, Muslima Chowdhury¹, Peter J. Charles², Michael G. Crooks³, Simon P. Hart³, Patrick Venables¹ and Benjamin A. Fisher⁴, ¹Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, ²Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, ³Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, ⁴Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom
Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
Abstract Number: 1213 • 2012 ACR/ARHP Annual Meeting
The Serum Cytokine Profile of Interstitial Lung Disease in Rheumatoid Arthritis
Jose Felix Restrepo¹, Inmaculada del Rincon², Roy Haas³, Daniel F. Battafarano⁴ and Agustin Escalante⁵, ¹Rheumatology, University of Texas Health Science Center, San Antonio, TX, ²Rheumatology, University Of Texas, Health Science Center, San Antonio, TX, ³Rheumatology, TX, ⁴Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX, ⁵Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX
Background/Purpose: Interstitial lung disease (ILD) is associated with significant morbidity and mortality in rheumatoid arthritis (RA). There are currently no proven biomarkers for ILD in…
Abstract Number: 423 • 2012 ACR/ARHP Annual Meeting
Sputa Autoantibodies in Patients with Established Rheumatoid Arthritis and Subjects At-Risk for Future Clinically Apparent Disease
Van C. Willis¹, M. Kristen Demoruelle², Lezlie A. Derber², Catherine J. Chartier-Logan¹, Mark Parish¹, Isabel Pedraza³, Michael H. Weisman⁴, Jill M. Norris⁵, V. Michael Holers⁶ and Kevin D. Deane², ¹Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Pulmonary and Critical Care Medicine, Cedars Sinai Med Ctr, Los Angeles, CA, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Epidemiology, Colorado School of Public Health, Aurora, CO, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Elevations of rheumatoid arthritis (RA)-related autoantibodies (Abs) prior to the symptomatic onset of inflammatory arthritis (IA) suggest that autoimmunity in RA is initiated outside…

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