ACR Meeting Abstracts

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Abstracts tagged "liver chemistry"

  • Abstract Number: 2529 • 2018 ACR/ARHP Annual Meeting

    Liver Function Test Levels with Sarilumab Treatment in Phase 3 Trials: Analysis By Baseline Liver Function Test (LFT) Level

    John Tesser1, Gregory St. John2, Toshio Kimura2, Stefano Fiore3, Maureen Rischmueller4, José A. Maldonado-Cocco5, Jürgen Braun6 and Jeffrey Kaine7, 1Arizona Arthritis & Rheumatology Associates, Glendale, AZ, 2Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 3Clinical Science, Sanofi Genzyme, Bridgewater, NJ, 4The University of Adelaide, Adelaide, Australia, 5Buenos Aires University School of Medicine, Buenos Aires, Argentina, 6Ruhr-University Bochum, Bochum, Germany, 7Sarasota Arthritis Research Center, Sarasota, FL

    Background/Purpose: Sarilumab showed efficacy in RA and superiority to placebo and adalimumab in Phase 3 trials. This post hoc analysis investigated LFT levels in three…
  • Abstract Number: 2380 • 2017 ACR/ARHP Annual Meeting

    The Use of Fibroscan in Detecting Early Liver Fibrosis in RA Patients on Long Term MTX with Normal Liver Enzymes

    Malack Alachkar1, T Mathialahan2, Sandra Walsh2 and Vun Lim3, 1Rheumatology, The Pennine Acute Hospitals NHS Trust, Manchester, United Kingdom, 2Gastroenterology, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham, United Kingdom, 3Rheumatology, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham, United Kingdom

    Background/Purpose: FibroScan (FS) is a non-invasive investigation that allows assessment of possible liver fibrosis by measuring liver stiffness. There are studies which confirm that MTX-related…
  • Abstract Number: 1987 • 2013 ACR/ARHP Annual Meeting

    LIVER Outcomes In Gout Patients Treated With Febuxostat and Altered LIVER Function TESTS

    Fernando Perez-Ruiz1,2 and Ana M. Herrero-Beites2,3, 1Servicio de Reumatologia, Hospital Universitario Cruces, Baracaldo, Spain, 2BioCruces Health Research Institute, Baracaldo, Spain, 3Physical Medicine Division, Hospital de Gorliz, Gorliz, Spain

    LIVER OUTCOMES IN GOUT PATIENTS TREATED WITH FEBUXOSTAT AND ALTERED LIVER FUNCTION TESTSBackground/Purpose: patients with significantly altered liver function test (LFTs) at screening do not…
  • Abstract Number: 459 • 2013 ACR/ARHP Annual Meeting

    Transaminase Levels and Hepatic Events Observed During Tocilizumab Treatment: Pooled Analysis Of Long-Term Clinical Trial Safety Data In Patients With Rheumatoid Arthritis

    MC Genovese1, Joel M. Kremer2, Ronald F. van Vollenhoven3, Rieke Alten4, Juan José Scali5, Ariella Kelman6, Lucy Rowell7 and Laura Pitts7, 1Division of Immunology and Rheumatology, Stanford University Medical Center, Palo Alto, CA, 2Center for Rheumatology, Albany Medical College, Albany, NY, 3Karolinska Institute, Stockholm, Sweden, 4Teaching Hospital of the Charité, University of Berlin, Berlin, Germany, 5Durand University Hospital, Buenos Aires, Argentina, 6Genentech, South San Francisco, CA, 7Roche, Welwyn Garden City, United Kingdom

    Background/Purpose: The interleukin-6 receptor inhibitor tocilizumab (TCZ) has demonstrated efficacy in improving signs/symptoms, reducing joint damage, and improving function and is well tolerated in patients…
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