Abstracts tagged "livedo reticularis and mTor"

Abstract Number: 162 • 2018 ACR/ARHP Annual Meeting
Mammalian Target of Rapamycin (mTOR) Pathway Assessment in Antiphospholipid Antibody Positive Patients with Livedo Reticularis/racemosa
Ecem Sevim¹, Salma Siddique², Susan Chyou³, William D. Shipman³, Ines Eugenio-Fernandez⁴, Ariel Badger⁴, Orla O`Shea⁵, Stephane Zuily⁶, Joanna Harp⁷, Cynthia Magro⁸, Oral Alpan⁹, Theresa T. Lu¹⁰ and Doruk Erkan¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Pediatric Rheumatology, Nemours Children's Health System, Wilmington, DE, ³Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ⁴O&O Alpan Medical Center, Fairfax, VA, ⁵Analytical Microscopy Core Laboratory, Hospital for Special Surgery, New York, NY, ⁶Université de Lorraine, CHRU Nancy, Nancy, France, ⁷Dermatology, Weill Cornell Medicine, New York, NY, ⁸Pathology, Weill Cornell Medicine, New York, NY, ⁹Allergy & Immunology, O&O Alpan Medical Center, Fairfax, VA, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY
Background/Purpose: Endothelial proliferation is a key finding in antiphospholipid antibody (aPL)-positive patients with microthrombosis. The mTOR pathway plays a role in the endothelial proliferation leading…

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