Abstracts tagged "lipids and scleroderma"

Abstract Number: 763 • 2014 ACR/ARHP Annual Meeting
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Rebecca Lee¹, Charles Reese², Michael Bonner¹, Beth Perry³, Richard M. Silver⁴, Richard P. Visconti⁵, Stanley Hoffman³ and Elena Tourkina⁶, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ⁵Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…

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