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Abstracts tagged "lipids and rheumatoid arthritis (RA)"

  • Abstract Number: 497 • 2018 ACR/ARHP Annual Meeting

    Increased Concentration of Large Very Low Density Lipoprotein Particles Associates with Progression of Carotid Atherosclerosis in Rheumatoid Arthritis

    Ilana Golub1, Jennifer Wang2, Ani Shahbazian1, John Moriarty1 and Christina Charles-Schoeman3, 1University of California, Los Angeles, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA, 3Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a marked increase in cardiovascular (CV) morbidity and mortality compared to the general population. Conventional lipid profiles are…
  • Abstract Number: 1484 • 2016 ACR/ARHP Annual Meeting

    Exploring the Link Between RA Disease Activity, Lipid Levels, and Cardiovascular Disease in an Early Inflammatory Arthritis Cohort

    Saurash Reddy, Xiaobo Meng and Carol Hitchon, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose:  Rheumatoid arthritis (RA) has been established as a risk factor for cardiovascular disease (CVD), with systemic inflammation being linked with atherosclerosis. Traditional CVD risk…
  • Abstract Number: 2051 • 2016 ACR/ARHP Annual Meeting

    Risk Factors for Cardiovascular Disease Predate the Onset of Symptoms of Rheumatoid Arthritis

    Heidi Kokkonen1, Lisbeth Ärlestig2 and Solbritt Rantapää-Dahlqvist3,4, 1Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 2Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 3Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 4Rheumatology, Umeå University, Umeå, Sweden

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk of developing cardiovascular (CV) comorbidity compared with the general population. Contradictory results concerning CV disease…
  • Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting

    Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)

    Giuliana Ascone1, Irene Di Ceglie1, Wouter de Munter1, Birgitte Walgreen2, Annet Sloetjes1, Peter M. van der Kraan1, Ernst Lindhout3, Mike Martens3 and Peter L. E. M. van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental, Radboud university medical center, Nijmegen, Netherlands, 3Future Diagnostics Solutions (FDs), Wijchen, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
  • Abstract Number: 2549 • 2016 ACR/ARHP Annual Meeting

    Effect of Interleukin-6 Receptor Blockade on Proprotein Convertase Subtilisin/Kexin Type 9 Serum Levels in Rheumatoid Arthritis Patients

    Maria Vanesa Hernandez-Hernandez1, Esmeralda Delgado-Frias2, Beatriz Tejera3, Cristina Luna Gomez4, Jose Ramon Muñiz5,6, De Vera-González AM7, Sagrario Bustabad8, Ivan Ferraz-Amaro8 and Federico Díaz-González9, 1Rheumatology, Hospital Universitario de Canarias, San Cristobal de la Laguna, Spain, 2Rheumatology, Hospital Universitario de Canarias, La Laguna, Spain, 3Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 4Rosario S/N, H. Ntra. Sra. La Candelaria, Santa Cruz de Teneri, Spain, 5Radiology, Hospital Universitario de Canarias, San Cristobal de la Laguna, Spain, 6Radiology, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 7Central Laboratory Division, Hospital Universitario de Canarias, San Cristobal de La Laguna, Spain, 8Rheumatology, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, 9Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain

    Background/Purpose: Rheumatoid arthritis (RA) has been acknowledged to increase cardiovascular mortality probably due, in part, to a lipid profile different from that observed in the…
  • Abstract Number: 2607 • 2016 ACR/ARHP Annual Meeting

    Favorable Changes in Lipid Profile with Additive DMARD Therapy in Rheumatoid Arthritis Patients Failing Methotrexate Monotherapy

    Tate Johnson1, Ted R Mikuls2, Harlan Sayles1, Michael J. Duryee3, Geoffrey M. Thiele1, Mary Brophy4,5 and James R. O'Dell6, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4VA Boston Heathcare System, Boston, MA, 5MAVERIC CSPCC (151MAV), VA Boston Healthcare System, Boston, MA, 6Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Cardiovascular disease is a significant comorbidity among RA patients. As such, dyslipidemia and the effect of DMARD therapy on lipid profiles is an important…
  • Abstract Number: 2633 • 2016 ACR/ARHP Annual Meeting

    Effect of Different Biologic Agents on Lipid Profile in Rheumatoid Arthritis

    Fabio Cacciapaglia1, Simone Perniola1, Mariangela Nivuori1, Margherita Giannini1, Olga Magazzino1, Maria Giannotta1, Florenzo Iannone2 and Giovanni Lapadula1, 1Interdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, General Hospital, Bari, Italy, 2Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, General Hospital, Bari, Italy

    Background/Purpose:  o examine any change between different biologic agents on lipid profile of RA patients. Methods:  Patients affected by RA, according to the 2010 EULAR/ACR…
  • Abstract Number: 3093 • 2016 ACR/ARHP Annual Meeting

    Comparison of Changes in Cardiovascular Risk-Associated Biomarkers in RA Patients Treated with Anti-TNF or Other Biological Agents: A Metabolic Study from a Randomized Trial

    Alexandre Virone1, Jean-Philippe Bastard2, Soraya Fellahi2, Jacqueline Capeau2, Stéphanie Rouanet3, Jean Sibilia4, Philippe Ravaud5, Francis Berenbaum6, Jacques-Eric Gottenberg7 and Jeremie Sellam6, 1Rheumatology, Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 2APHP Hôpital Tenon, Sorbonne Universités, UPMC Univ Paris-6, Inserm UMR_S938, ICAN, DHU i2B, Paris, France, 3StatEthic, Levallois-Perret, France, 4Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 5Hôpital Hôtel Dieu, Paris, France, 6Rheumatology dept, APHP St-Antoine hospital, Univ Paris 06, Paris, France, Paris, France, 7Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France

    Background/Purpose: Considering the increased cardiovascular risk in RA patients and the influence of biologics, especially tocilizumab (TCZ) on the lipid profile, we aimed to investigate…
  • Abstract Number: 1474 • 2016 ACR/ARHP Annual Meeting

    Increased Levels of Lipoprotein(a) in RA Patients with Cardiovascular Disease

    Sverre Holm1,2, Ingvild Oma3, Tor-Arne Hagve4, Kjell Saatvedt5, Knut Mikkelsen6, Hans Rydningen7, Sven Martin Almdahl8, Pål Aukrust9,10, Bente Halvorsen9,11 and Ivana Hollan6,12,13,14, 1Hospital For Rheumatic Diseases, Lillehammer, Norway, 2Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 3Innlandet Hospital Trust, Lillehammer, Norway, 4Oslo University Hospital, Rikshospitalet, Oslo, Norway, 5Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway, 6Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, 7Feiring Heart Clinic, Feiring, Norway, 8Department of Cardiothoracic Surgery, University Hospital of North Norway, Tromsø, Norway, 9Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 10Research Intitute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 11Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 12Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 13Harvard Medical School, Boston, MA, 14Department of Medicine, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Patients with various inflammatory rheumatic diseases (IRD) have increased cardiovascular morbidity caused by atherosclerosis. The aetiology of the accelerated atherosclerosis in IRD is still…
  • Abstract Number: 484 • 2015 ACR/ARHP Annual Meeting

    Race Plays a Role in Influencing the Modest Lipid Lowering Effects of Hydroxychloroquine in Patients with Rheumatoid Arthritis, Independent of Statin Use

    Myriam Guevara1, Bernard NG1 and Nancy Gove2, 1Rheumatology, University of Washington, Seattle, WA, 2Biostatistics, Seattle Children's, Seattle, WA

    Background/Purpose: Despite remarkable improvements in RA treatment, there is evidence indicating that the mortality gap between RA patients and the general population is not closing.…
  • Abstract Number: 1508 • 2015 ACR/ARHP Annual Meeting

    Lipid Target Achievement Among Patients with Recent-Onset Rheumatoid Arthritis during the First Six Years of Follow-up: Results from a French Multicenter Cohort of Early Arthritis

    Anne Tournadre1, Bruno Pereira2, Jean-Jacques Dubost3, Nathalie Rincheval4, Anne-Christine Rat5,6, Bernard Combe7 and Martin Soubrier3, 1Rheumatology, UNH-UMR 1019 INRA University of Auvergne and Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 2Biostatistics unit (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France, 3Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 4Lapeyronie Hospital, Montpellier I University, UMR 5535, EA2415, Montpellier, France, 5CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, 6CHU de Nancy, Rheumatology, Nancy, France, 7Rheumatology, Hopital Lapeyronie, Montpellier, France

    Background/Purpose: Cardiovascular mortality is increased in rheumatoid arthritis (RA) and RA is an independent risk factor leading to a rapid increase in risk following diagnosis.…
  • Abstract Number: 1510 • 2015 ACR/ARHP Annual Meeting

    The Association Between HDL Cholesterol Efflux Capacity, Citrullinated ApoA1 and Anti-Citrullinated ApoA1 Antibodies in Rheumatoid Arthritis

    Katherine Liao1, Jing Cui1, Christopher Rhodes2, Lauren J. Lahey2, Martin Playford3, I-Hsin Kuo1, Michelle Frits1, Christine Iannaccone1, Jonathan S. Coblyn4, Michael Weinblatt1, Nancy Shadick5, Nehal N. Mehta3 and Jeremy Sokolove2, 1Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA, 2Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, 3NHLBI, National Institutes of Health, Bethesda, MD, 4Brigham & Women's Hospital, Boston, MA, 5Division of Rheumatology, Immunology & Allergy, Brigham & Women's Hospital, Boston, MA

    Background/Purpose: High density lipoprotein (HDL) cholesterol efflux capacity measures how well HDL particles remove cholesterol from lipid-laden macrophages, such as those found in atherosclerotic plaques. …
  • Abstract Number: 1545 • 2015 ACR/ARHP Annual Meeting

    Comparison of Statin Eligibility According to the Adult Treatment Panel III, ACC/AHA Blood Cholesterol Guideline and Presence of Carotid Plaque By Ultrasound in Hispanics with Rheumatoid Arthritis

    Alberto Cardenas-de La Garza1, Raymundo Vera-Pineda2, Dionicio A. Galarza-Delgado1, Jose Ramon Azpiri-Lopez3, Iris J. Colunga-Pedraza1, Jesus Zacarias Villarreal-Pérez4, Griselda Serna-Peña5 and Mario Alberto Garza-Elizondo1, 1Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, 2Cardiology., Hospital Universitario, UANL., Monterrey, Mexico, 3Cardiology, Hospital Universitario, UANL., Monterrey, Mexico, 4Endocrinology, Hospital Universitario, UANL., Monterrey, Mexico, 5Internal Medicine, Hospital Universitario, UANL., Monterrey, Mexico

    Background/Purpose: Atherosclerotic cardiovascular disease (ASCVD) is the number one cause of death in rheumatoid arthritis (RA) patients. RA itself is an independent risk factor for…
  • Abstract Number: 1547 • 2015 ACR/ARHP Annual Meeting

    Implementing an Electronic Medical Recorded-Based Clinical Decision Support Tool Did Not Improve Cardiovascular Risk Screening in Rheumatoid Arthritis Patients

    Anand Kumthekar1, Michail Alevizos2, Nicole Jordan3 and Anna R. Broder4, 1Medicine, Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, 2Medicine, Albert Einstien College of Medicine/Jacobi Medical Center, Bronx, NY, 3Montefiore Medical Center, New York, NY, 4Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY

    Background/Purpose: Cardiovascular disease (CVD) is the leading cause of death among individuals with rheumatoid arthritis (RA).  The 2010 EULAR guidelines recommend annual CV risk assessment…
  • Abstract Number: 2127 • 2015 ACR/ARHP Annual Meeting

    Exploring the Lipid Paradox Theory in Rheumatoid Arthritis: Subclinical Coronary Atherosclerosis Is Higher Among Rheumatoid Arthritis Patients with the Lowest Circulating Low Density Lipoprotein Concentrations Compared with Controls

    Jon T. Giles1, Mary Chester M. Wasko2, Cecilia P. Chung3, Amy Kao4, Sabahat Bokhari5, Afshin Zartoshti6, C. Michael Stein7 and Joan M. Bathon8,9, 1Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 2West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, 3Division of Rheumatology & Immunology, Vanderbilt University School of Medicine, Nashville, TN, 4Biogen, Cambridge, MA, 5Cardiology, Columbia University Medical Center, NY, NY, 6Rheumatology, Columbia University Medical Center, NY, NY, 7Div of Clinical Pharmacology, Vanderbilt University, Nashville, TN, 8Medicine, Columbia University, College, New York, NY, 9Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY

    Background/Purpose: Several recent studies have identified RA patients with very low levels of circulating total and low density lipoprotein cholesterol (LDL-C) to be at particularly…
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