Abstracts tagged "lipids and lupus nephritis"

Abstract Number: 1746 • 2016 ACR/ARHP Annual Meeting
Immune Complex-Induced IL-6 Production By Lupus Prone Mesangial Cells Is Mediated By Neuraminidase Activity
Tamara K. Nowling¹, Kamala Sundararaj² and Leah Siskind³, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Pharmacology and Toxicology, University of Louisville, Louisville, KY
Background/Purpose: We made the novel observation that glycosphingolipid (GSL) levels and neuraminidase (NEU) (an enzyme that mediates GSL catabolism) activity/expression are altered in the kidneys…
Abstract Number: 1632 • 2014 ACR/ARHP Annual Meeting
Is Liopxin A4 a Biomarker for Systemic Lupus Erythematosus?
Manal Sedky Abdou¹, Dina Effat², Lamiaa Mansour³, Mona mohsen Abdul Salam³ and Noha abd El Baky⁴, ¹rheumatology and rehabilitation kasr el aini hospital, faculty of medicin, cairo university, cairo, Egypt, ²rheumatology and rehabilitation, faculty of medicin, cairo university, giza, Egypt, ³clinical and chemical pathology, faculty of medicin, cairo university, cairo, Egypt, ⁴rheumatology and rehabilitation, faculty of medicin, cairo university, cairo, Egypt
Background/Purpose : Systemic lupus erythematosus (SLE) is characterized by autoantibody production and immune complex deposition which trigger both a local and systemic inflammatory response. The…
Abstract Number: 661 • 2014 ACR/ARHP Annual Meeting
Dysfunction of Glycosphingolipid Metabolism in Lupus Nephritis
Thirumagal Thiyagarajan¹, Leah Siskind², Jim Oates³, Richard Drake⁴ and Tamara K. Nowling⁵, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²University of Louisville, Louisville, KY, ³Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ⁴Pharmacology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: Lupus is a chronic autoimmune disease characterized by autoantibody production and aberrant activation and proliferation of lymphocytes. Subsequent deposition of immune complexes in target…
Abstract Number: 2339 • 2012 ACR/ARHP Annual Meeting
Lowering Fli1 Levels Decreases the Levels of Lipid Mediators in the Kidneys and T Cells of MRL/Lpr Lupus Prone Mice
Marlene Bunni¹, Zainab Amani², Andrew Mather³, Jennifer Berglind Schepp³, Leah Siskind³ and Tamara K. Nowling⁴, ¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ³Pharmaceutical & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, ⁴Medicine/Rheumatology, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…

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