Abstracts tagged "Lesions"

Abstract Number: 2100 • 2018 ACR/ARHP Annual Meeting
Topical Endocannabinoid Administration Protects MRL-Lpr/Lpr Mice from Cutaneous Lupus Erythematosus
Samantha Chalmers¹, Sayra Garcia¹, Andrew Draganski¹, Jessica Doerner², Adam Friedman³, Joel Friedman¹ and Chaim Putterman⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Pennsylvania, Philadelphia, PA, ³Dermatology, GW School of Medicine and Health Sciences, Washington, DC, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Cutaneous lupus erythematosus (CLE) affects ~75% of SLE patients and has a profound impact on quality of life. While the morbidity from CLE is…
Abstract Number: 587 • 2017 ACR/ARHP Annual Meeting
Detection of Structural Lesions on T1 Weighted MRI Versus Radiography of the Sacroiliac Joints in Early Axial Spa: 2-Year Data
Walter P. Maksymowych¹, Pascal Claudepierre², Manouk de Hooge³, Robert G. Lambert⁴, Robert B.M. Landewé⁵, Anna Molto⁶, Désirée van der Heijde³, Jack F Bukowski⁷, Heather Jones⁸, Isabelle Logeart⁹, Lisa Marshall⁸, Ronald Pedersen¹⁰, Annette Szumski¹¹, Bonnie Vlahos¹² and Maxime Dougados¹³, ¹Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ²Universite Paris Est Creteil, Paris, France, ³Leiden University Medical Center, Leiden, Netherlands, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁶Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁷Clinical Affairs, Pfizer, Collegeville, PA, ⁸Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ⁹Medical Affairs, Pfizer, France, Paris, France, ¹⁰Department of Biostatistics, Pfizer, Collegeville, PA, ¹¹inVentiv Health, Princeton, NJ, ¹²Clinical Sciences, Pfizer, Collegeville, PA, ¹³Hopital Cochin, Paris Descartes University, Paris, France
Background/Purpose: At the SI joint (SIJ) level, several methods exist for evaluating structural damage, e.g., MRI, CT scan, radiographs. In EMBARK (NCT01258738) and DESIR (NCT01648907),…
Abstract Number: 2802 • 2017 ACR/ARHP Annual Meeting
Sustained Remission of Inflammation Is Associated with Reduced Structural Damage on SI Joint MRI in Patients with Early Axial Spa: Evidence to Support the Concept of Treat-to-Target
Walter P. Maksymowych¹, Pascal Claudepierre², Manouk de Hooge³, Robert G. Lambert⁴, Robert B.M. Landewé⁵, Anna Molto⁶, Désirée van der Heijde³, Jack F Bukowski⁷, Heather Jones⁸, Isabelle Logeart⁹, Lisa Marshall⁸, Ronald Pedersen¹⁰, Annette Szumski¹¹, Bonnie Vlahos¹² and Maxime Dougados¹³, ¹Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ²Universite Paris Est Creteil, Paris, France, ³Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ⁵Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ⁶Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁷Clinical Affairs, Pfizer, Collegeville, PA, ⁸Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ⁹Medical Affairs, Pfizer, France, Paris, France, ¹⁰Department of Biostatistics, Pfizer, Collegeville, PA, ¹¹Biostatistics, inVentiv Health, Princeton, NJ, ¹²Clinical Sciences, Pfizer, Collegeville, PA, ¹³Hopital Cochin, Paris Descartes University, Paris, France
Background/Purpose: Treat-to-target is an accepted strategy in RA; however, it is unknown whether it will reduce/prevent disability, impairment of mobility, and structural damage in patients…
Abstract Number: 1172 • 2015 ACR/ARHP Annual Meeting
Single Cell Sequencing of Non-Lesional Non-Sun Exposed Skin from SLE Patients with Proteinuria Supports Widespread Endothelial Activation
Robert Clancy¹, Evan Der², Kemal Akat³, Anna R. Broder⁴, H. Michael Belmont⁵, Peter M. Izmirly⁶, Beatrice Goilav⁷, Thomas Tuschl³, Chaim Putterman⁸ and Jill P. Buyon¹, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Rockefeller University, New York, NY, ⁴Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ⁵New York University School of Medicine, New York, NY, ⁶Rheumatology, NYU School of Medicine, New York, NY, ⁷Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁸Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Given the widespread vasculopathy present in SLE, endothelial cell activation in the renal tubulointerstitium in lupus nephritis (LN) may be accompanied by similar activation…
Abstract Number: 2025 • 2015 ACR/ARHP Annual Meeting
Modification of Structural Lesions on Magnetic Resonance Imaging By Etanercept: A 12-Week Randomized Placebo-Controlled Trial
Walter Maksymowych¹, Stephanie Wichuk², Maxime Dougados³, Heather Jones⁴, Annette Szumski⁵, Lisa Marshall⁴, Jack F Bukowski⁶ and Robert G Lambert⁷, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology Research Lab, University of Alberta, Edmonton, AB, Canada, ³Rheumatology Department, Hôpital Cochin, Paris, France, ⁴Inflammation Global Medical Affairs, Pfizer, Collegeville, PA, ⁵Department of Biostatistics, Pfizer, Collegeville, PA, ⁶Clinical Affairs, Pfizer, Collegeville, PA, ⁷Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Modification of structural lesions by anti-TNF therapy has not been demonstrated in a randomized placebo (PBO)-controlled trial. The Spondyloarthritis Research Consortium of Canada (SPARCC)…
Abstract Number: 2250 • 2014 ACR/ARHP Annual Meeting
The Effects of Treatment on Disease Symptoms and Progression of Structural Changes in Knee Osteoarthritis Participants from the Osteoarthritis Initiative Progression Cohort
Jean-Pierre Pelletier¹, Camille Roubille¹, François Abram², Marc Dorais³, Philippe Delorme¹, Jean-Pierre Raynauld¹ and Johanne Martel-Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³StatSciences Inc., Notre-Dame de l’Île-Perrot, QC, Canada
Background/Purpose: In the perspective of personalized management of osteoarthritis (OA), a clinically relevant concern is the impact of meniscal extrusion on response to treatment. This study evaluated the role…
Abstract Number: 1893 • 2014 ACR/ARHP Annual Meeting
Substantial Structural Lesions on MRI in the Sacroiliac Joints of Patients with Non-Radiographic Axial Spondyloarthritis Even in the Absence of MRI Inflammation
Walter P. Maksymowych¹, S Wichuk¹, H Jones², A Szumski³, L Marshall⁴, J Bukowski⁵ and RG Lambert⁶, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Inflammation & Immunology, Pfizer Inc., Collegeville, PA, ³Specialty Care, Pfizer Inc., Collegeville, PA, ⁴Inflammation Immunology Disease Group, Pfizer Inc., Collegeville, PA, ⁵Pfizer Inc., Collegeville, PA, ⁶Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Treatment of axial SpA is increasingly aimed at intervention early in the disease course before radiographic sacroiliitis has appeared and when response to treatment…
Abstract Number: 1424 • 2014 ACR/ARHP Annual Meeting
Bone Erosions in Patients with RA: Exploring the Impact of the Anatomy of Interest on the Relationship Between MRI and X-Ray Erosion Detection
Michael Tomizza¹, Isabel Rodrigues¹, Matthew Jessome¹, Joshua Barbosa¹, Karen Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Karen Finlay³, Chris Gordon², Lawrence Hart², George Ioannidis², Erik Jurriaans³, Melissa Koh¹, Maggie Larche², Arthur Lau², Naveen Parasu³, Ruben Tavares², Stephen Tytus², Hao Wu¹ and Jonathan D. Adachi^1,2, ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose: Detection of bone erosions in patients with RA is critical in clinical practice, with treatment initiation and effectiveness largely based on limiting erosive progression.…
Abstract Number: 1186 • 2014 ACR/ARHP Annual Meeting
Prevalence of MRI Spinal Lesions Typical for Axial Spondyloarthritis in Patients with Inflammatory Back Pain
Manouk de Hooge¹, Jean-Baptiste Pialat², Antoine Feydy³, Monique Reijnierse¹, Pascal Claudepierre⁴, Alain Saraux⁵, Maxime Dougados³ and Désirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Hôpital Edouard Herriot, Lyon, France, ³Descartes University, Cochin Hospital, Paris, France, ⁴Henri Mondor Teaching Hospital, Creteil, France, ⁵CHU de la Cavale Blanche, Brest Cedex, France
Background/Purpose: A cut-off value of ³3 inflammatory lesions was suggested by the ASAS/OMERACT group, as positive MRI of the spine (MRI-spine). Moreover, fatty lesions on…
Abstract Number: 1172 • 2014 ACR/ARHP Annual Meeting
Assessing the Validity and Reliability of a Novel MRI Semi-Automated Algorithm for Quantifying Bone Loss in the Hand
Matthew Jessome¹, Isabel Rodrigues², Michael Tomizza², Joshua Barbosa², Melissa XP. Koh¹, Karen Beattie³, William G. Bensen³, Raja Bobba³, Alfred Cividino³, Patrick D. Emond³, Karen Finlay⁴, Chris Gordon³, Lawrence Hart³, George Ioannidis³, Erik Jurriaans⁴, Maggie Larche³, Arthur Lau³, Naveen Parasu⁴, Ruben Tavares³, Stephen Tytus³, Hao Wu² and Jonathan D. Adachi^2,3, ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁴Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose Efficient and accurate evaluation of erosive damage to the MCP joints in RA patients is desirable in both clinical trials and clinical practice. The…
Abstract Number: 855 • 2014 ACR/ARHP Annual Meeting
Active and Structural Lesions on MRI of the Sacroiliac Joints Predict Major Clinical Responses in Patients with Non-Radiographic Axial Spondyloarthritis Treated with Etanercept
Walter P. Maksymowych¹, S Wichuk¹, H Jones², A Szumski³, L Marshall⁴, J Bukowski⁵ and RG Lambert⁶, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Inflammation & Immunology, Pfizer Inc., Collegeville, PA, ³Specialty Care, Pfizer Inc., Collegeville, PA, ⁴Inflammation Immunology Disease Group, Pfizer Inc., Collegeville, PA, ⁵Pfizer Inc., Collegeville, PA, ⁶Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Previous studies evaluating predictors of major clinical response in patients with non-radiographic axial SpA (nr-axSpA) receiving treatment with anti-TNF agents have been limited by…
Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting
The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years
Yi Chao Foong¹, Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Flavia Cicuttini³ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…
Abstract Number: 238 • 2013 ACR/ARHP Annual Meeting
Structural Predictors Of Ten Year Knee Cartilage Volume Loss
Dawn Aitken¹, Hussain Ijaz Khan¹, Changhai Ding², Leigh Blizzard³, Jean-Pierre Pelletier⁴, Johanne Martel-Pelletier⁴, Flavia Cicuttini⁵ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Statistics, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia, ⁴Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ⁵Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: Cartilage volume loss is considered a key feature of knee osteoarthritis (OA) and increased loss over two years is associated with future knee replacement…

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