KIR (Killer Ig like receptor) Archives

Abstract Number: 150 • Pediatric Rheumatology Symposium 2020
The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Jennifer Frankovich¹, Kirstin Anderson ², Gonzalo Montero-Martin ³, Avis Chan ⁴, Margo Thienemann ⁵, Bahare Farhadian ⁶, Theresa Willett ⁵, Elizabeth Mellins ⁷, Alicia Madden ⁵, Tanya Murphy ⁸, Susan Swedo ⁹, Marcelo Fernandez-Vina ³ and Jill Hollenbach ², ¹Stanford, ²University of California San Francisco, San Francisco, California, ³Stanford University, Palo Alto, California, ⁴Stanford University School of Medicine, Palo Alto, ⁵Stanford University School of Medicine, Palo Alto, California, ⁶Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ⁷Stanford University, Stanford, ⁸University of South Florida, Tampa, Florida, ⁹National Institute of Mental Health, Bethesda, Maryland
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. Patients with…
Abstract Number: 610 • ACR/ARP Annual Meeting 2019
Ankylosing Spondylitis-associated Killer Immunoglobin-like Receptors Are Strongly Expressed on γδ T Cells
Micah Lefton¹, Nihaarika Sharma ¹ and Joerg Ermann ², ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston
Background/Purpose: The mechanism underlying the association between ankylosing spondylitis (AS) and HLA-B27 is still unknown. One of the hypotheses involves the interaction of HLA-B27 homodimers…
Abstract Number: 61 • ACR/ARHP Annual Meeting 2016
Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis
Aimee Hanson¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Kim-Anh Lê Cao³, Tony J. Kenna⁴ and Matthew A. Brown², ¹The University of Queensland Diamantina Institute, Translational Research Instiute, Brisbane, Australia, Brisbane, Australia, ²Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Background/Purpose: Killer immunoglobulin-like receptors (KIRs) are expressed predominantly on the surface of natural killer (NK) cells and some T-cells and are important in regulating the…
Abstract Number: 715 • ACR/ARHP Annual Meeting 2013
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression In CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…
Abstract Number: 2495 • ACR/ARHP Annual Meeting 2013
Ankylosing Spondylitis Protective Endoplasmic Reticulum Aminopeptidase 1 Variants Lead To Decreased Natural Killer Cell Conjugation and Activation
Hasan Abdullah¹, Zhenbo Zhang², Robert Inman³ and Nigil Haroon⁴, ¹IMS, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto, ON, Canada, ³Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: Ankylosing Spondylitis (AS) is an inflammatory arthritis affecting the axial and peripheral joints. Human Leukocyte Antigen (HLA)-B27 and Endoplasmic Reticulum Aminopeptidase (ERAP) 1 genes…
Abstract Number: 1655 • ACR/ARHP Annual Meeting 2013
HLA-B27 and KIR3DL2 Interactions Promote The Differentiation and Survival Of Proinflammatory T Cells In Spondyloarthritis
A. Ridley¹, I. Wong-Baeza², H. Hatano², J. Shaw², H. Al-Mossawi², P. Bowness² and S. Kollnberger², ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: T helper 17 (Th17) cells are a subset of pro-inflammatory CD4+ T cells implicated in a number of inflammatory arthritides including the Spondyloarthritides (SpAs). …
Abstract Number: 2317 • ACR/ARHP Annual Meeting 2012
Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells
Dipak R. Patel, Gabriela Gorelik and Bruce C. Richardson, Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: CD4+CD28- T cells are enriched in chronic inflammatory diseases like rheumatoid arthritis (RA) and lupus. They are cytotoxic and resistant to apoptosis. Compared to…

Abstracts tagged "KIR (Killer Ig like receptor)"

The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

Ankylosing Spondylitis-associated Killer Immunoglobin-like Receptors Are Strongly Expressed on γδ T Cells

Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis

Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression In CD4+ T Cells

Ankylosing Spondylitis Protective Endoplasmic Reticulum Aminopeptidase 1 Variants Lead To Decreased Natural Killer Cell Conjugation and Activation

HLA-B27 and KIR3DL2 Interactions Promote The Differentiation and Survival Of Proinflammatory T Cells In Spondyloarthritis

Protein Phosphatase 5 (PP5) Regulates Methylation Sensitive Gene Expression in CD4+ T Cells