Abstracts tagged "kinase"

Abstract Number: 1799 • 2012 ACR/ARHP Annual Meeting
ONO-4059 – A Novel Small Molecule Bruton’s Tyrosine Kinase (Btk) Inhibitor, Suppresses Osteoclast Differentiation and Activation
Yuko Ariza, Toshio Yoshizawa, Yoshiko Ueda, Shingo Hotta, Masami Narita and Kazuhito Kawabata, Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose: Bruton’s tyrosine kinase (Btk) is primarily expressed in B cells, mast cells, platelets, myeloid cells and osteoclasts. Osteoclast differentiation is regulated by signaling pathways…
Abstract Number: 1741 • 2012 ACR/ARHP Annual Meeting
Suppression of Glomerulonephritis in NZB/W F1 Mice by a Selective Inhibitor of Bruton’s Tyrosine Kinase (RN486)
Paola Mina-Osorio¹, Jacob LaStant¹, Natalie Keirstead¹, Toni Whittard¹, Stella Stefanova¹, Alka Patel¹, Jennifer Postelnek¹, John Woods², Soo Min², Yong Kim¹, Julie Demartino², Satwant Narula³ and Daigen Xu¹, ¹Inflammation, Hoffmann-La Roche, Nutley, NJ, ²Inflammation Discovery, Hoffmann-La Roche, Nutley, NJ, ³Inflammatory Discovery, Hoffmann-La Roche, Nutley, NJ
Background/Purpose: Bruton tyrosine kinase (Btk) is a Tec family kinase that participates in B cell receptor (BCR), Toll-like Receptor (TLR) and chemokine receptor signaling. It…

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