Abstracts tagged "kinase and syk"

Abstract Number: 644 • 2014 ACR/ARHP Annual Meeting
HM-0523, a Novel Syk Inhibitor Blocks Glomerulonephritis and Extends Life Spans in Lupus Prone MRL/Lpr Mice
Yu Cai¹, Zhipeng Wu¹, Ping Ren¹, Xiaoming Dai¹, Jianlin He¹, Fang Yin¹, Wei Deng¹, Guangxiu Dai¹, Weiguo Su¹ and Xiong Li², ¹Hutchison Medipharma Limited, Shanghai, China, ²Building 4, 720 Cai Lun Road,, Hutchison Medipharma Limited, Shanghai, China
Background/Purpose: Syk is a key mediator of signaling events downstream of a wide array of receptors important for immune functions, including the B cell receptor,…
Abstract Number: 474 • 2013 ACR/ARHP Annual Meeting
HM-0523, a Novel Syk Inhibitor Significantly Ameliorates The Severity Of Arthritis In Rodents
Yu Cai¹, Zhong Cui Sun¹, Ping Ren¹, Lei Fang¹, Xiaoming Dai¹, Zhipeng Wu¹, Qianqian Dong², Xinrong Wang¹, Jian Wang¹, Yang Sai¹, Xiong Li¹ and Weiguo Su¹, ¹Hutchison Medipharma Limited, Shanghai, China, ²Inflammation & Immunology Research, Hutchison Medipharma Limited, Shanghai, China
Background/Purpose: Spleen tyrosine kinase (SYK) is a key mediator of signaling events downstream of a wide array of receptors important for immune function, including the…

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