Abstracts tagged "kinase and rheumatologic disease"

Abstract Number: 1062 • 2012 ACR/ARHP Annual Meeting
Identification of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases
Divya Chaudhary¹, Shaughnessy Robinson², Craig E. Masse¹, Matthew D. Wessel², Shawn Watts², Jeremy Greenwood², Mee Shelley², Mark Brewer², Geraldine Harriman¹, Leah L. Frye², Ronald T. Wester¹, Rosana Kapeller¹ and Donna Romero¹, ¹25 First Street Suite 404, Nimbus Discovery, Inc., Cambridge, MA, ²Schrödinger, Inc., New York, NY
Background/Purpose: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key mediator of the innate immune response orchestrated by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), IL-33…

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Abstracts tagged "kinase and rheumatologic disease"

Identification of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases