Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 2856 • 2017 ACR/ARHP Annual Meeting
Evaluation of a Dosing Regimen for Tocilizumab in Patients Younger Than Two Years of Age with Systemic Juvenile Idiopathic Arthritis
Navita L. Mallalieu¹, Joy Hsu¹, Karen Wang¹, Sunethra Wimalasundera², Wendy Douglass², Chris Wells², Inmaculada Calvo³, Rubén Cuttica⁴, Hans-Iko Huppertz⁵, Rik Joos⁶, Yukiko Kimura⁷, Diana Milojevic⁸, Margalit Rosenkranz⁹, Kenneth Schikler¹⁰, Tamas Constantin¹¹ and Carine Wouters¹², ¹Roche Innovation Center, New York, NY, ²Roche Products, Ltd., Welwyn Garden City, United Kingdom, ³Hospital Universitario y Politécnico La Fe, Valencia, Spain, ⁴Hospital Gral de Niños Pedro Elizalde, Buenos Aires, Argentina, ⁵Professor Hess Children's Hospital, Bremen, Germany, ⁶ZNA, Antwerp, and UZ, Gent, Belgium, ⁷Hackensack University Medical Center, Hackensack, NJ, ⁸Tufts Medical Center, Boston, MA, ⁹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ¹⁰University of Louisville Medical School, Louisville, KY, ¹¹Semmelweis University, Budapest, Hungary, ¹²University Hospital Gasthuisberg, Leuven, Belgium
Background/Purpose: Tocilizumab (TCZ) is approved for the treatment of systemic juvenile idiopathic arthritis (sJIA) based on clinical trials in patients ≥2 years of age. This…
Abstract Number: 2280 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Switching to Adalimumab As the Second- and Third-Line Biological Drug in Patients with Juvenile Idiopathic Arthritis
Ekaterina Alexeeva¹, Tatiana Dvoryakovskaya², Victor Gladkikh^3,4, Andrei Moskalev^4,5, Rina Denisova¹, Ksenia Isaeva¹, Olga Lomakina¹, Margarita Soloshenko¹ and Anna Karaseva¹, ¹Reumatology department, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, ²Pediatrics, The Federal State Autonomous Educational Institution of Higher Education The First Moscow State Medical University named after I.M. Sechenov Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation, ³Department of Biostatistics, EOL Labs ltd, Novosibirsk, Rwanda, ⁴Laboratory of Computational Physics, Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk, Russian Federation, ⁵Department of Biostatistics, EOL Labs ltd, Novosibirsk, Russian Federation
Background/Purpose: The range of biological drugs currently used in JIA therapy includes not only anti-TNF but also other varieties. However, despite the high effectiveness and…
Abstract Number: 2857 • 2017 ACR/ARHP Annual Meeting
Short and Long-Term Follow-up of Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis
Nuria Vegas-Revenga¹, Vanesa Calvo-Río¹, Montserrat Santos-Gómez², Inmaculada Calvo³, Mº Isabel González- Fernández³, Berta López- Montesinos³, Marina Mesquida⁴, Alfredo Adan⁴, M. Victoria Hernández⁴, Olga Maiz⁵, Antonio Atanes⁶, Beatriz Bravo⁷, Consuelo Modesto⁸, Gisela Díaz-Cordovés⁹, Natalia Palmou-Fontana¹, Javier Loricera¹, MC Gonzalez-Vela¹⁰, Rosalia Demetrio¹¹, Carlos Fernández-Díaz¹, Lucia C. Domínguez-Casas¹, José Luis Martín-Varillas¹, Belén Atienza-Mateo¹, Jose L. Hernández¹², Miguel Angel González-Gay¹ and Ricardo Blanco¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, ³Rheumatology, Hospital Universitario i Politecnico La Fe. Valencia. Spain, Valencia, Spain, ⁴Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁵Hospital Donostia. Spain, San Sebastian, Spain, ⁶Rheumatology, Complejo Hospitalario Universitario A Coruña (CHUAC). Spain, A Coruna, Spain, ⁷Rheumatology, HU Virgen de las Nieves. Granada. Spain, Granada, Spain, ⁸Hospital Universitari Vall d'Hebron. Barcelona. Spain, Barcenola, Spain, ⁹Rheumatology, Hospital Regional Universitario de Málaga. Spain, Málaga, Spain, ¹⁰Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹¹Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹²Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Our objective was to assess the efficacy of tocilizumab (TCZ) at short and long term follow-up for severe juvenile idiopathic arthritis-associated uveitis.Methods: A Multicentre…
Abstract Number: 2281 • 2017 ACR/ARHP Annual Meeting
Patterns of Medication Use in Non-Systemic Polyarthritis: Data from the Childhood Arthritis and Rheumatology Research Alliance Patient Registry
Sarah Ringold¹, Fenglong Xie², Daniel B. Horton³, Melissa L. Mannion⁴, Colleen K. Correll⁵, Anne C. Dennos⁶ and Timothy Beukelman⁷, ¹Seattle Children's Hospital, Seattle, WA, ²Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ⁴Pediatric rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Minnesota, Minneapolis, MN, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry began enrolling children with juvenile idiopathic arthritis (JIA) in July 2015. The large number of…
Abstract Number: 2858 • 2017 ACR/ARHP Annual Meeting
Validation of Biomarkers to Predict Flare in Polyarticular JIA upon Stopping Anti-TNF Therapy
Daniel J Lovell¹, Sarah Ringold² and P. Scott Eastman³, ¹PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Seattle Children's Hospital, Seattle, WA, ³Senior Director, New Product Development, Crescendo Bioscience, South San Francisco, CA
Background/Purpose: More than 40% of children with polyarticular forms of Juvenile Idiopathic Arthritis (JIA) experience clinical inactive disease on medication (CR). No clinical variable or…
Abstract Number: 2286 • 2017 ACR/ARHP Annual Meeting
Determinants of Anti-Tumor Necrosis Factor Drug Use in Juvenile Spondyloarthropathy and Impact on Clinical Disease Outcomes
Melissa Oliver¹, Julia F Simard², Dana Gerstbacher³, Tzielan Lee⁴ and Christy Sandborg⁵, ¹Pediatric Rheumatology, Stanford University, Department of Pediatric Rheumatology, Palo Alto, CA, ²Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA, ³Stanford University, Palo Alto, CA, ⁴Pediatric Rheumatology, Stanford University, Palo Alto, CA, ⁵Pediatric Rheumatology PTD, Stanford Medical Center, Palo Alto, CA
Background/Purpose: Patients with juvenile spondyloarthropathy (JSpA) have lower clinical remission rates, report higher pain scores, worse functioning and lower quality of life compared to other…
Abstract Number: 2952 • 2017 ACR/ARHP Annual Meeting
A Randomized Controlled Trial (RCT) of an Internet-Based Self-Management Program for Adolescents with Juvenile Idiopathic Arthritis (JIA)
Jennifer N. Stinson¹, Sarah Campillo², Tania Cellucci³, Paul Dancey⁴, Ciarán M. Duffy⁵, Janet Ellsworth⁶, Brian M. Feldman⁷, Adam Huber⁸, Nicole Johnson⁹, Patrick McGrath⁸, Alan Rosenberg¹⁰, Natalie J. Shiff¹¹, Lynn R. Spiegel¹², Shirley M.L. Tse¹³, Lori Tucker¹⁴, J. Charles Victor¹⁵ and Stephanie Luca¹⁶, ¹Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Montreal Children's Hospital, Montreal, QC, Canada, ³McMaster University, hamilton, ON, Canada, ⁴Pediatrics, Janeway Children's Hospital, St. John's, NL, Canada, ⁵Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁸IWK Health Centre, Halifax, NS, Canada, ⁹Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ¹⁰Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ¹¹University of Florida, Gainesville, FL, ¹²Rheumatology/Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ¹³Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ¹⁴BC Children's Hospital, Vancouver, BC, Canada, ¹⁵University of Toronto, Toronto, ON, Canada, ¹⁶The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common chronic childhood illness associated with negative impact on health-related quality of life (HRQL). As teens mature, they…
Abstract Number: 2293 • 2017 ACR/ARHP Annual Meeting
Can We Predict Achievement of Clinically Inactive Disease and Sustained Remission in Children with Juvenile Idiopathic Arthritis?
Stephanie Shoop-Worrall¹, Suzanne M Verstappen², Janet E. McDonagh³, Wendy Thomson⁴ and Kimme L. Hyrich¹, ¹The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ³Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom
Background/Purpose: Identifying predictors for clinically inactive disease (CID) and sustained remission would allow rapid escalation of therapies for children less likely to achieve these states.…
Abstract Number: 2994 • 2017 ACR/ARHP Annual Meeting
Improving Outcomes Using a Treat to Target Approach and Clinical Decision Support in Polyarticular Juvenile Idiopathic Arthritis
Lisa Buckley¹, Eileen Ware², Genna Kreher², Lisa Wiater¹, Jay Mehta¹ and Jon (Sandy) Burnham¹, ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Office of Clinical Quality Improvement, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Polyarticular juvenile idiopathic arthritis (Poly-JIA) causes pain, functional disability, and joint damage. Variation in Poly-JIA clinical assessment and treatment likely has a negative…
Abstract Number: 2294 • 2017 ACR/ARHP Annual Meeting
Utilizing the Pediatric Rheumatology Care and Outcomes Improvement Network to Assess Practice Pattern Variation in Juvenile Idiopathic Arthritis
Emily A. Smitherman¹, Janalee Taylor², Esi M. Morgan¹ and C. April Bingham³, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Pediatrics, Penn State College of Medicine, Hershey, PA
Background/Purpose: Despite modern treatment options for patients with juvenile idiopathic arthritis (JIA), rates of clinical inactive disease (CID) remain low. The Pediatric Rheumatology Care and…
Abstract Number: 2295 • 2017 ACR/ARHP Annual Meeting
Methotrexate As First Line Therapy in Juvenile Idiopathic Arthritis-Associated Uveitis: Myth or Reality
Jacopo Agnolucci¹, Maria Elisabetta Zannin¹, Giorgia Martini¹, Alessandra Meneghel² and Francesco Zulian², ¹Department of Woman and Child Health, University of Padua, Padua, Italy, ²University of Padua, Department of Woman and Child Health, Padua, Italy
Background/Purpose: Methotrexate (MTX) is the most used immunomodulatory drug in Juvenile Idiopathic Arthritis-associated uveitis (JIA-U) although its efficacy has been shown only in retrospective studies…
Abstract Number: 2297 • 2017 ACR/ARHP Annual Meeting
Golimumab Versus Tocilizumab in Uveitis Related to Refractory Juvenile Idiopathic Arthritis. National Multicenter Study of 33 Patients
Lucia C. Domínguez-Casas¹, Vanesa Calvo-Río¹, Inmaculada Calvo², Mª Isabel González-Fernández³, Berta Lopez Montesinos³, Marina Mesquida⁴, Alfredo Adan⁴, M. Victoria Hernández⁴, Olga Maiz-Alonso⁵, Ana Blanco⁶, Antonio Atanes⁷, Beatriz Bravo⁸, Consuelo Modesto⁹, Gisela Díaz-Cordovés¹⁰, Miguel Cordero-Coma¹¹, David Diaz-Valle¹², Carlos Fernández-Cid¹³, Juan Cruz¹⁴, Oscar Ruiz Moreno¹⁵, MC Gonzalez-Vela¹⁶, Rosalía Demetrio-Pablo¹⁷, Nuria Vegas-Revenga¹, Carlos Fernández-Díaz¹, Jose L. Hernández¹⁸, Miguel Angel González-Gay¹ and Ricardo Blanco¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Pediatric Rheumatology, Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, ³Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, ⁴Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁵Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, ⁶Ophtamology. Hospital Donostia. San Sebastian. Spain, San Sebastian, Spain, ⁷Rheumatology, Complejo Hospitalario Universitario A Coruña (CHUAC). Spain, A Coruna, Spain, ⁸Rheumatology. Hospital Universitario Virgen de las Nieves. Granada. Spain, Granada, Spain, ⁹Hospital Universitari Vall d'Hebron. Barcelona. Spain, Barcenola, Spain, ¹⁰Rheumatology, Hospital Regional Universitario de Málaga. Spain, Málaga, Spain, ¹¹Ophthalmology, Hospital de León. Spain, León, Spain, ¹²Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, ¹³Ophtalmology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, ¹⁴Rheumatology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, ¹⁵Ophthalmology and Rheumatology., Ophtalmology. Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, ¹⁶Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹⁷Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹⁸Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Uveitis is a severe manifestation of Juvenil Idiopathic Arthritis (JIA). Systemic treatment is based on conventional immunosuppresants. Anti-TNFa are used in refractory cases, mainly…
Abstract Number: 2298 • 2017 ACR/ARHP Annual Meeting
Etanercept, Adalimumab and Methotexate Utilization By Juvenile Idopathic Arthritis Patients and the Occurrence of Uveitis
Katherine Roshak¹, Joan M Sopczynski², Ricardo Suehiro² and Lisa Marshall¹, ¹Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ²Pfizer, Collegeville, PA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic arthritis with onset before 16 years of age, that persists for at least 6 weeks, and has…
Abstract Number: 2302 • 2017 ACR/ARHP Annual Meeting
The Impact of JIA on Physician and Patient-Reported Outcomes over the First Five Years Following Diagnosis
Stephanie Shoop-Worrall¹, Suzanne M Verstappen², Janet E. McDonagh³, Wendy Thomson⁴ and Kimme L. Hyrich⁴, ¹The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal and Dermatology Research, Faculty of Medicine, Biology and Health, United Kingdom, University of Manchester, Manchester, United Kingdom, ³Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, ⁴National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Information regarding longer-term outcomes in JIA largely pre-date the introduction of biologic therapies and have been cross-sectional. The aim of this analysis was to…
Abstract Number: 66 • 2017 Pediatric Rheumatology Symposium
Feasibility Testing of An Internet-Based Psycho-Educational Game for Children with Juvenile Idiopathic Arthritis and Their Parents
Jennifer N. Stinson¹, Mark Connelly², Adam Huber³, Nadia Luca⁴, Lynn R. Spiegel⁵, Argerie Tsimicalis⁶, Stephanie Luca⁷, Naweed Tajuddin⁷, Roberta Berard⁸, Julie Barsalou⁹, Sarah Campillo^10,11, Brian Feldman¹², Shirley M.L. Tse¹³, Paul Dancey¹⁴, Ciarán M. Duffy¹⁵, Nicole Johnson¹⁶, Patrick McGrath³, Natalie J. Shiff¹⁷, Lori Tucker¹⁸ and J. Charles Victor¹⁹, ¹Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Children's Mercy Hospital, Kansas City, MO, ³IWK Health Centre, Halifax, NS, Canada, ⁴Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ⁵Rheumatology/Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ⁶McGill University, Montreal, QC, Canada, ⁷The Hospital for Sick Children, Toronto, ON, Canada, ⁸Pediatrics, Children's Hospital, London Health Sciences Centre, London, ON, Canada, ⁹CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada, ¹⁰Rheumatology, Montreal Children's Hospital, Montreal, QC, Canada, ¹¹Montreal Children's Hospital, Montreal, QC, Canada, ¹²Department of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ¹³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁴Pediatrics, Janeway Children's Hospital, St. John's, NL, Canada, ¹⁵Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ¹⁶Pediatrics, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ¹⁷University of Florida, Gainesville, FL, ¹⁸Pediatric Rheum/Rm K4-120, BC Childrens Hospital, Vancouver, BC, Canada, ¹⁹University of Toronto, Toronto, ON, Canada
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common chronic illness in childhood. The responsibility of JIA management during the younger years is shared among family…

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