Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 979 • 2018 ACR/ARHP Annual Meeting
Stopping Medicines for Inactive Juvenile Idiopathic Arthritis: What Do Patients and Families Consider?
Daniel B. Horton^1,2, Jomaira Salas³, Aleksandra Wec⁴, Timothy Beukelman⁵, Alexis Boneparth⁶, Jaime Guzman⁷, Ky Haverkamp⁸, Melanie Kohlheim⁹, Melissa L. Mannion⁵, Nandini Moorthy¹, Elizabeth Stringer¹⁰, Lori Tucker⁷, Sarah Ringold¹¹ and Marsha Rosenthal², ¹Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Rutgers Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ³Department of Sociology, Rutgers, the State University of New Jersey, New Brunswick, NJ, ⁴Mathematica Policy Research, Princeton, NJ, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Pediatrics, Columbia University Medical Center, New York, NY, ⁷Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ⁸Family Medicine, University of Washington School of Medicine, Seattle, WA, ⁹Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, OH, ¹⁰IWK Health Centre, Dalhousie University, Halifax, NS, Canada, ¹¹Pediatrics, Seattle Children's Hospital, Seattle, WA
Background/Purpose: Prior research has focused on factors important to clinicians in decisions about withdrawing JIA therapy. Based on recent interviews with patients and caregivers about…
Abstract Number: 2420 • 2018 ACR/ARHP Annual Meeting
Pregnancy Outcome and Perinatal Complications of Neonate Born to Mothers with Juvenile Idiopathic Arthritis in Asia
Chao-Yi Wu¹, Shang-Chun Changchien², Huang-Yu Yang³, Kuo-Wei Yeh⁴ and Jing-Long Huang^1,2, ¹Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ²Medicine, Chang-Gung University, Taoyuan city, Taiwan, ³Department of Nephrology,, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, ⁴Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan, Taiwan
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the leading pediatric rheumatic disease affecting 30 out of a million women. Although spontaneous remission may occur in most…
Abstract Number: 2295 • 2017 ACR/ARHP Annual Meeting
Methotrexate As First Line Therapy in Juvenile Idiopathic Arthritis-Associated Uveitis: Myth or Reality
Jacopo Agnolucci¹, Maria Elisabetta Zannin¹, Giorgia Martini¹, Alessandra Meneghel² and Francesco Zulian², ¹Department of Woman and Child Health, University of Padua, Padua, Italy, ²University of Padua, Department of Woman and Child Health, Padua, Italy
Background/Purpose: Methotrexate (MTX) is the most used immunomodulatory drug in Juvenile Idiopathic Arthritis-associated uveitis (JIA-U) although its efficacy has been shown only in retrospective studies…
Abstract Number: 2297 • 2017 ACR/ARHP Annual Meeting
Golimumab Versus Tocilizumab in Uveitis Related to Refractory Juvenile Idiopathic Arthritis. National Multicenter Study of 33 Patients
Lucia C. Domínguez-Casas¹, Vanesa Calvo-Río¹, Inmaculada Calvo², Mª Isabel González-Fernández³, Berta Lopez Montesinos³, Marina Mesquida⁴, Alfredo Adan⁴, M. Victoria Hernández⁴, Olga Maiz-Alonso⁵, Ana Blanco⁶, Antonio Atanes⁷, Beatriz Bravo⁸, Consuelo Modesto⁹, Gisela Díaz-Cordovés¹⁰, Miguel Cordero-Coma¹¹, David Diaz-Valle¹², Carlos Fernández-Cid¹³, Juan Cruz¹⁴, Oscar Ruiz Moreno¹⁵, MC Gonzalez-Vela¹⁶, Rosalía Demetrio-Pablo¹⁷, Nuria Vegas-Revenga¹, Carlos Fernández-Díaz¹, Jose L. Hernández¹⁸, Miguel Angel González-Gay¹ and Ricardo Blanco¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ²Pediatric Rheumatology, Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, ³Rheumatology. Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, ⁴Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁵Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, ⁶Ophtamology. Hospital Donostia. San Sebastian. Spain, San Sebastian, Spain, ⁷Rheumatology, Complejo Hospitalario Universitario A Coruña (CHUAC). Spain, A Coruna, Spain, ⁸Rheumatology. Hospital Universitario Virgen de las Nieves. Granada. Spain, Granada, Spain, ⁹Hospital Universitari Vall d'Hebron. Barcelona. Spain, Barcenola, Spain, ¹⁰Rheumatology, Hospital Regional Universitario de Málaga. Spain, Málaga, Spain, ¹¹Ophthalmology, Hospital de León. Spain, León, Spain, ¹²Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, ¹³Ophtalmology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, ¹⁴Rheumatology. Hospital de Pontevedra. Pontevedra. Spain, Pontevedra, Spain, ¹⁵Ophthalmology and Rheumatology., Ophtalmology. Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, ¹⁶Pathology Anatomy, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹⁷Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, ¹⁸Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Uveitis is a severe manifestation of Juvenil Idiopathic Arthritis (JIA). Systemic treatment is based on conventional immunosuppresants. Anti-TNFa are used in refractory cases, mainly…
Abstract Number: 2298 • 2017 ACR/ARHP Annual Meeting
Etanercept, Adalimumab and Methotexate Utilization By Juvenile Idopathic Arthritis Patients and the Occurrence of Uveitis
Katherine Roshak¹, Joan M Sopczynski², Ricardo Suehiro² and Lisa Marshall¹, ¹Inflammation & Immunology Global Medical Affairs, Pfizer, Collegeville, PA, ²Pfizer, Collegeville, PA
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic arthritis with onset before 16 years of age, that persists for at least 6 weeks, and has…
Abstract Number: 2302 • 2017 ACR/ARHP Annual Meeting
The Impact of JIA on Physician and Patient-Reported Outcomes over the First Five Years Following Diagnosis
Stephanie Shoop-Worrall¹, Suzanne M Verstappen², Janet E. McDonagh³, Wendy Thomson⁴ and Kimme L. Hyrich⁴, ¹The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal and Dermatology Research, Faculty of Medicine, Biology and Health, United Kingdom, University of Manchester, Manchester, United Kingdom, ³Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, ⁴National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Information regarding longer-term outcomes in JIA largely pre-date the introduction of biologic therapies and have been cross-sectional. The aim of this analysis was to…
Abstract Number: 1259 • 2017 ACR/ARHP Annual Meeting
Perspectives of Young People with Juvenile Idiopathic Arthritis, Their Caregivers, and Health Care Providers on Transition to Adult Care: Informing Development of a Transition Toolkit
Nadia Luca¹, Evelyn Rozenblyum², April Elliott³, Lynn R. Spiegel⁴, Nicole Johnson⁵, Sara Ahola Kohut⁶, Yvonne Brandelli³, Carolyn Johns⁷, Stephanie Luca⁸, Dianne P. Mosher⁹, Gordon Soon¹⁰, Karine Toupin-April¹¹, Gabriela Uifalusi³ and Jennifer N. Stinson¹², ¹Pediatric Rheumatology, University of Calgary, Alberta Children's Hospital, Calgary, AB, Canada, ²Royal University Hospital, Saskatoon, SK, Canada, ³Alberta Children's Hospital, Calgary, AB, Canada, ⁴Rheumatology/Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ⁶Hospital for Sick Children, Toronto, ON, Canada, ⁷Alberta Health Services, Calgary, AB, Canada, ⁸The Hospital for Sick Children, Toronto, ON, Canada, ⁹Med, University of Calgary, Calgary, AB, Canada, ¹⁰Pediatric Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ¹¹Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada, ¹²Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Transition from pediatric to adult care is an important process for adolescents and young adults with Juvenile Idiopathic Arthritis (JIA). A seamless transition is…
Abstract Number: 2305 • 2017 ACR/ARHP Annual Meeting
Efficacy of Function-Based Exercise Program on Functional Ability, Pain and Quality of Life in Children with Juvenile Idiopathic Arthritis
Ela Tarakci¹, Saime Nilay Baydogan¹, Sezgin Sahin², Amra Adrovic², Kenan Barut² and Ozgur Kasapcopur², ¹Istanbul University, Faculty of Health Science, Division of Physiotherapy and Rehabilitation, Istanbul, Turkey, ²Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood, affecting at least 1 in 1000 children. Children with JIA,…
Abstract Number: 1739 • 2017 ACR/ARHP Annual Meeting
Vδ1, Vδ2, and Other γδT Cells in Blood and Synovium of Rheumatoid Arthritis and Other Autoimmune Arthritides
Anna Helena Jonsson¹, Michael Gurish¹, Lauren Henderson², Peter Nigrovic¹ and Michael Brenner³, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Innate-like T cells comprise on average 10-15% of peripheral T cell and have T-cell receptors (TCRs) that engage ligands other than classic HLA class…
Abstract Number: 2314 • 2017 ACR/ARHP Annual Meeting
Monoarticular Juvenile Idiopathic Arthritis: A Unique Entity?
Caterina Politi¹, Vanessa Cecchin¹, Fabio Vittadello¹, Alessandra Meneghel², Giorgia Martini¹ and Francesco Zulian², ¹Department of Woman and Child Health, University of Padua, Padua, Italy, ²University of Padua, Department of Woman and Child Health, Padua, Italy
Background/Purpose: Oligoarticular Juvenile Idiopathic Arthritis (oligoJIA) is the most common JIA subtype. According with the most recent classification criteria1, monoarticular JIA (monoJIA) is included in…
Abstract Number: 1800 • 2017 ACR/ARHP Annual Meeting
Do Patient Reported Outcome Measurement Information System (PROMIS) Computer Adaptive Tests Correlate with Disease Activity in Juvenile Idiopathic Arthritis?
Rebecca Trachtman¹, Elizabeth T. Murray², Jackie Szymonifka³, Alexa Adams⁴, Nancy Pan⁴, Sarah Taber⁴, Thomas J. A. Lehman⁴, Karen Onel⁴ and Lisa A. Mandl⁵, ¹Pediatric Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, NY, NY, ²Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Pediatric Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, ⁵Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY
Background/Purpose: The importance of patient-reported outcomes is increasingly recognized both in clinical care and in research. PROMIS is an NIH-supported collection of patient-reported outcome measures,…
Abstract Number: 2315 • 2017 ACR/ARHP Annual Meeting
Symptoms of Depression and Anxiety in Children with JIA: Relation to Other Domains of Health Related Quality of Life
Michael Miller¹, Yufan Yan² and George Lales³, ¹Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is associated with symptoms of anxiety and depression. We studied these symptoms and other health related quality of life (HRQOL)…
Abstract Number: 2270 • 2017 ACR/ARHP Annual Meeting
Identification of Optimal Subcutaneous Doses of Tocilizumab in Children with Polyarticular-Course Juvenile Idiopathic Arthritis
Hermine I. Brunner¹, Nicola Ruperto², Alberto Martini², Athimalaipet V. Ramanan³, Rubén Cuttica⁴, Jennifer E. Weiss⁵, Michael Henrickson¹, Heinrike Schmeling⁶, Jordi Anton⁷, Kirsten Minden⁸, Joy Hsu⁹, Kamal Bharucha¹⁰, Sunethra Wimalasundera¹¹, Alysha K. Kadva¹⁰, Ruchi Upmanyu¹¹, Navita L. Mallalieu⁹, Wendy Douglass¹¹, Daniel J Lovell¹ and Fabrizio De Benedetti¹², ¹Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati, OH, ²PRINTO Coordinating Centre, Genoa, Italy, ³Bristol Royal Hospital for Children, Bristol, United Kingdom, ⁴Hospital Gral de Niños Pedro Elizalde, Buenos Aires, Argentina, ⁵Hackensack University Medical Center, Hackensack, NJ, ⁶Alberta Children’s Hospital/University of Calgary, Calgary, AB, Canada, ⁷Hospital Sant Joan de Deu, Barcelona, Spain, ⁸Charité – University of Medicine Berlin, Berlin, Germany, ⁹Roche Innovation Center, New York, NY, ¹⁰Genentech, South San Francisco, CA, ¹¹Roche Products, Ltd., Welwyn Garden City, United Kingdom, ¹²Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy
Background/Purpose: The efficacy and safety of intravenous (IV) tocilizumab (TCZ), an interleukin-6 receptor-alpha inhibitor, have been demonstrated in patients with polyarticular-course juvenile idiopathic arthritis (pcJIA)…
Abstract Number: 2322 • 2017 ACR/ARHP Annual Meeting
Quantitative Proteomics Comparison of Children with Inactive and Active Uveitis
Sheila Angeles-Han¹, Duc Duong², Steven Yeh³, Purnima Patel⁴, Virginia Miraldi Utz⁵, Kirsten Jenkins⁶, Danielle Lowe⁷, Sampath Prahalad⁸ and Gary Holland⁹, ¹Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, ²Emory University, Atlanta, GA, ³Ophthalmology, Emory University School of Medicine, Atlanta, GA, ⁴Emory University School of Medicine, Atlanta, GA, ⁵Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, ⁶Children's Healthcare of Atlanta, Atlanta, GA, ⁷Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ⁹Jules Stein Eye Institute, Jules Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Children with chronic non-infectious uveitis are at high risk for sight-threatening complications and vision loss. No biomarker predicts uveitis development or treatment response. Aqueous…
Abstract Number: 2271 • 2017 ACR/ARHP Annual Meeting
Safety of Adalimumab±Methotrexate for the Treatment of Polyarticular Juvenile Idiopathic Arthritis (pJIA)
Hermine I. Brunner¹, Nicola Ruperto², Kabita Nanda³, Mary Toth⁴, Ivan Foeldvari⁵, John F. Bohnsack⁶, Diana Milojevic⁷, C. Egla Rabinovich⁸, Daniel J Kingsbury⁹, Katherine Marzan¹⁰, Pierre Quartier¹¹, Kirsten Minden¹², Elizabeth Chalom¹, Gerd Horneff¹³, Rolf M. Kuester¹⁴, Jason A Dare¹⁵, Mareike Bereswill¹⁶, Jasmina Kalabic¹⁶, Hartmut Kupper¹⁶, Daniel J Lovell¹ and Alberto Martini², ¹PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²PRINTO-IRCCS Gaslini, Genova, Italy, ³University of Washington School of Medicine and Seattle Children's Hospital, Bayside, NY, ⁴Akron Children's Hospital, Akron, OH, ⁵Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, ⁶University of Utah, Department of Pediatrics, Salt Lake City, UT, ⁷The Floating Hospital for Children at Tufts Medical Center, Boston, MA, ⁸Duke University Medical Center, Durham, NJ, ⁹Randall Children’s Hospital at Legacy Emanuel, Portland, OR, ¹⁰Children's Hospital Los Angeles, Los Angeles, CA, ¹¹Hopital Necker-Enfants Malades, Paris, France, ¹²Kinderklinik der Charite, Otto-Heubner Centrum, Berlin, Germany, ¹³Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, ¹⁴Orthopädiezentrum Altona, Hamburg, Germany, ¹⁵Arkansas Children’s Hospital, Little Rock, AR, ¹⁶AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: JIA is the most common chronic inflammatory rheumatic disease of childhood. Due to their known safety and efficacy, TNF inhibitors are used for long-term…

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