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Abstracts tagged "juvenile idiopathic arthritis (JIA)"

  • Abstract Number: 273 • 2014 ACR/ARHP Annual Meeting

    Long-Term Safety and Effectiveness of Adalimumab in Children with Moderately to Severely Active Polyarticular or Polyarticular-Course Juvenile Idiopathic Arthritis

    Hermine Brunner1, Nicola Ruperto2, Carol A. Wallace3, Mary Toth4, Ivan Foeldvari5, John Bohnsack6, Diana Milojevic7, C. Egla Rabinovich8, Pavla Vavrincova9, Daniel J. Kingsbury10, Katherine Marzan11, Pierre Quartier12, Kirsten Minden13, Elizabeth Chalom1, Gerd Horneff14, Rolf M. Kuester15, Jason Dare16, Mareike Bereswill17, Hartmut Kupper17, Jasmina Kalabic17, Daniel Lovell18 and Alberto Martini19, 1PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2PRINTO, Genoa, Italy, 3University of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, 4Akron Children's Hospital, Akron, OH, 5Department of Pediatric Rheumatology, Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg, Germany, 6University of Utah, Department of Pediatrics, Salt Lake City, UT, 7Pediatrics, Division of Pediatric Rheumatology, Floating Hospital for Children at Tufts Medical Center, Boston, MA, 8Duke University Medical Center, Durham, NC, 9Fakultni nemocnice v Motole, Praha, Czech Republic, 10Randall Children's Hospital at Legacy Emanuel, Portland, OR, 11Children's Hospital Los Angeles, Los Angeles, CA, 12Pediatric Rheumatology, IMAGINE Institute, Hôpital Necker-Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris-Descartes, Paris, France, 13Kinderklinik der Charite, Otto-Heubner Centrum, Berlin, Germany, 14Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, 15Asklepios Rheumazentrum Hamburg, Hamburg, Germany, 16Arkansas Children’s Hospital, Little Rock, AR, 17AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 18Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, 19PRINTO-IRCCS, Genova, Italy

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases of childhood. Adalimumab (ADA) is approved for moderate to severe polyarticular JIA…
  • Abstract Number: 2286 • 2014 ACR/ARHP Annual Meeting

    Food Allergy and Celiac Disease in Children with Juvenile Idiopathic Arthritis

    Trevor E. Davis1,2, Mei-Sing Ong3, Diana Milojevic2, Jyoti Ramakrishna4 and Marc D. Natter5, 1Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Pediatrics, Division of Pediatric Rheumatology, Floating Hospital for Children at Tufts Medical Center, Boston, MA, 3Australian Institute of Health Innovation, University of New South Wales, Sydney, Australia, 4Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Floating Hospital for Children at Tufts Medical Center, Boston, MA, 5Intelligent Health Labs, Children's Hospital Boston, Boston, MA

    Background/Purpose: There are multiple strong associations between gut pathology and rheumatologic diseases. This connection, between primary GI disease and rheumatologic diseases, is manifest in both…
  • Abstract Number: 272 • 2014 ACR/ARHP Annual Meeting

    Factors Associated with Choice of First Biologic Among Children with Juvenile Idiopathic Arthritis: A Combined Analysis from 2 UK Paediatric Biologic Registers

    Rebecca Davies1, Lianne Kearsley-Fleet1, Eileen Baildam2, Michael W. Beresford3, Helen E. Foster4, Taunton R. Southwood5, Wendy Thomson6, Kimme L. Hyrich7, on Behalf Of The BSPAR Etanercept Cohort Study1 and The Biologics for Children with Rheumatic Diseases (BCRD) study1, 1Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 2Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, 3Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 5Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, 6Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 7Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom

    Background/Purpose: The management of juvenile idiopathic arthritis (JIA) has been revolutionised by the introduction of biologics such as etanercept (ETN), approved in the UK in…
  • Abstract Number: 2290 • 2014 ACR/ARHP Annual Meeting

    Race and Other Risk Markers of Uveitis in a Prospective Cohort of Children with Juvenile Idiopathic Arthritis

    Sheila T. Angeles-Han1, Courtney McCracken1, Steven Yeh2, Kirsten Jenkins3, Erica Myoung4, Daneka Stryker4, Kelly A. Rouster-Stevens5, Larry B. Vogler1, Christine Kennedy6, Sampath Prahalad1 and Carolyn Drews-Botsch7, 1Emory University School of Medicine, Atlanta, GA, 2Ophthalmology, Emory University School of Medicine, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA, 4Emory University, Atlanta, GA, 5Pediatrics, Emory University School of Medicine, Atlanta, GA, 6Rheumatology Immunology, Emory Children's Center, Atlanta, GA, 7Epidemiology, Emory University School of Public Health, Atlanta, GA

    Background/Purpose Juvenile idiopathic arthritis-associated uveitis (JIA-U) can lead to poor visual outcomes.  American Academy of Pediatric guidelines recommend screening every 3 months in children with…
  • Abstract Number: 271 • 2014 ACR/ARHP Annual Meeting

    Predicting Treatment Response to Etanercept in Juvenile Idiopathic Arthritis: Results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study (BSPAR-ETN)

    Lianne Kearsley-Fleet1, Rebecca Davies1, Mark Lunt1, Taunton R. Southwood2, Kimme L. Hyrich3 and on Behalf Of The BSPAR Etanercept Cohort Study1, 1Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 2Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, 3Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Etanercept (ETN) is licensed in Europe for use in children with Juvenile Idiopathic Arthritis (JIA) and is routinely prescribed after failure of other DMARDs.…
  • Abstract Number: 1866 • 2014 ACR/ARHP Annual Meeting

    Birth Outcomes in Women with a History of Juvenile Idiopathic Arthritis

    Debbie Ehrmann Feldman1, Evelyne Vinet2, Sasha Bernatsky3, Ciaran Duffy4, Elizabeth Hazel5, Marie-Pierre Sylvestre6, Garbis Meshefedjian7 and Anick Bérard1, 1Université de Montréal, Montréal, QC, Canada, 2McGill University Health Center, Montreal, QC, Canada, 3Clinical Epidemiology - Rheumatology, McGill University, Montreal, QC, Canada, 4Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 5McGill University Heatlh Center, Montreal, QC, Canada, 6médecine sociale et préventive, Université de Montréal, Montréal, QC, Canada, 7Public Health Department of Montreal, Montreal, QC, Canada

    Background/Purpose: Although there is a higher frequency of adverse birth outcomes in women with rheumatoid arthritis, little is known on the subject regarding women who…
  • Abstract Number: 276 • 2014 ACR/ARHP Annual Meeting

    Growth during Tocilizumab Therapy for Polyarticular-Course Juvenile Idiopathic Arthritis: 2-Year Data from a Phase 3 Clinical Trial

    Kamal N. Bharucha1, Hermine I. Brunner2, Nicola Ruperto3, David A. Cabral2, Abraham Gedalia2, Valeria Gerloni3, Christian Jorgensen3, Athimalaipet Ramanan3, Daniel Lovell2, Alberto Martini4, James Frane5, Chris Wells6 and Fabrizio De Benedetti Sr.7, 1Genentech, South San Francisco, CA, 2PRCSG, Cincinnati, OH, 3PRINTO, Genoa, Italy, 4Istituto Giannina Gaslini, Genova, Italy, 5Consultant, Santa Monica, CA, 6Roche Products Ltd., Welwyn Garden City, United Kingdom, 7Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy

    Background/Purpose: Elevated interleukin-6 (IL-6) levels have been associated with low growth velocity in patients with juvenile idiopathic arthritis (JIA).1 The efficacy of tocilizumab (TCZ), an…
  • Abstract Number: 1444 • 2014 ACR/ARHP Annual Meeting

    The Vocational Experiences of Young People with Juvenile Idiopathic Arthritis and the Role of the Multidisciplinary Team Supporting Positive Employment Outcomes

    Helen Hanson1, Ruth Hart2, Alison Jordan3, Rachel Tattersall4, Ben Thompson1 and Helen E. Foster5, 1Rheumatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, 2Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 4Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 5Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Recent decades have seen marked changes in the management of juvenile idiopathic arthritis (JIA), with improved clinical outcomes for many patients. However, unemployment rates…
  • Abstract Number: 198 • 2014 ACR/ARHP Annual Meeting

    Implant Survival and Patient-Reported Outcomes after Total Hip Arthroplasty in Young Patients with JIA

    Ishaan Swarup1, Ella Christoph1, Lisa A. Mandl2, Susan M. Goodman2 and Mark P. Figgie3, 1Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Orthopedics, Hospital for Special Surgery, New York, NY

    Background/Purpose :  Juvenile Idiopathic Arthritis (JIA) is a common rheumatologic disease in children that often persists into adulthood.  The hip joint is commonly involved, and…
  • Abstract Number: 1313 • 2014 ACR/ARHP Annual Meeting

    Comorbidity Patterns in Children with Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus: The Childhood Arthritis and Rheumatology Research Alliance Registry

    Marc D. Natter1, Mei-Sing Ong2, Kenneth D. Mandl3, Laura Schanberg4, Yukiko Kimura5, Norman Ilowite6 and the CARRA Registry Investigators, 1Intelligent Health Labs, Children's Hospital Boston, Boston, MA, 2Australian Institute of Health Innovation, University of New South Wales, Sydney, Australia, 3Intelligent Health Lab, Children's Hospital Boston, Boston, MA, 4Duke University, Durham, NC, 5Pediatric Rheumatology, Hackensack Univ Medical Ctr, Hackensack, NJ, 6Rheumatology, Children's Hospital Montefiore, Bronx, NY

    Background/Purpose: Knowledge of co-occurring disease processes (comorbidities) is important for understanding disease pathogenesis, refining disease classifications, developing appropriate screening and prevention strategies, and determining overall…
  • Abstract Number: L2 • 2014 ACR/ARHP Annual Meeting

    A Comparison of Three Treatment Strategies in Recent Onset DMARD Naïve Juvenile Idiopathic Arthritis: 3-Months Results of the BeSt for Kids-Study

    Petra C.E. Hissink Muller1,2, D.M.C. Brinkman1,3, Dieneke Schonenberg4, Yvonne Koopman-Keemink5, J. Merlijn Van den Berg6, W.P. Bekkering7, Marion van Rossum8,9, Lisette WA van Suijlekom-Smit10, Cornelia F. Allaart11 and Rebecca ten Cate1, 1Pediatric Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Pediatric Rheumatology, Reade, Amsterdam, Netherlands, 3Pediatric Rheumatology, Rijnland Hospital, Leiderdorp, Netherlands, 4Department of Pediatric Rheumatology and Immunology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands, 5Pediatrics, Haga ziekenhuis, The Hague, Netherlands, 6Pediatric Hematology, Immunology and Infectious diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands, 7Pediatric Physiotherapy, Leiden University Medical Center, Leiden, Netherlands, 8Pediatric Rheumatology Immunology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands, 9Reade, Amsterdam, Netherlands, 10Pediatric Rheumatology, Sophia Children's Hospital Erasmus Medical Center, Rotterdam, Netherlands, 11Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: BeSt for Kids compares 3 Disease Modifying Anti Rheumatic Drug (DMARD) strategies in juvenile idiopathic arthritis (JIA) patients, for time to inactive disease, time…
  • Abstract Number: 928 • 2014 ACR/ARHP Annual Meeting

    A Multinational Study of the Epidemiology, Treatment and Outcome of Childhood Arthritis: Preliminary Data from 6,940 Patients

    Alessandro Consolaro1, Amita Aggarwal2, Troels Herlin3, Olga Vougiouka4, Rubén Burgos-Vargas5, Ilonka Orban6, Nahid Shafaie7, Maria Trachana8, Lidia Rutkowska-Sak9, Ingrida Rumba-Rozenfelde10, Dimitrina Mihaylova11, Alberto Martini12,13 and Angelo Ravelli1,14, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 3Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark, 4P. A. Kyriakou Childrens Hospital of Athens University, Athens, Greece, 5Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, 6National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 7Rheumatology Research Centre, Tehran University of Medical Sciences, Tehran, Iran, 8Aristotle University, Thessaloniki, Greece, 9Institute of Rheumatology, Warsaw, Poland, 10University of Latvia, Riga, Latvia, 11University Children Hospital, Sofia, Bulgaria, 12Istituto Giannina Gaslini, Genova, Italy, 13University of Genova, Genova, Italy, 14Istituto Giannina Gaslini and University of Genova, Genova, Italy

    Background/Purpose The epidemiology of juvenile idiopathic arthritis (JIA) is known to be variable worldwide and the therapeutic approach to JIA is not standardized. Moreover, the…
  • Abstract Number: 303 • 2014 ACR/ARHP Annual Meeting

    Predicting Chronic Pain in Children with Juvenile Idiopathic Arthritis: Results from the Childhood Arthritis Prospective Study

    Amir Rashid1, Kate Holliday1, Lis Cordingley1, Roberto Carrasco1, Bo Fu2, Helen E. Foster3, Eileen Baildam4, Alice Chieng5, Joyce Davidson6, Lucy Wedderburn7, Kimme Hyrich8 and Wendy Thomson9, 1Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, 2Centre for Biostatistics, Institute of Population Health, The University of Manchester, Manchester, United Kingdom, 3Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 4Paediatric Rheumatology, Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, 5Paediatric Rheumatology, Royal Manchester Children's Hospital, Manchester, United Kingdom, 6Royal Hospital for Sick Children, Glasgow, United Kingdom, 7Rheumatology Unit , Institute of Child Health, University College London (UCL), London, United Kingdom, 8Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 9Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom

    ·         Background/Purpose: Pain is the most common symptom of JIA and has been associated with disease activity. However, disease activity has only accounted for a…
  • Abstract Number: 302 • 2014 ACR/ARHP Annual Meeting

    Qualitative Assessment of Important Long-Term Outcomes in Juvenile Idiopathic Arthritis

    Melissa L. Mannion1, Michelle Williams2, Gerald McGwin Jr.3, Kenneth G. Saag4 and Timothy Beukelman1, 1Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 3Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose JIA is not a childhood disease, but a chronic disease that begins in childhood. Long term outcomes that physicians and patients care most about…
  • Abstract Number: 301 • 2014 ACR/ARHP Annual Meeting

    Pregnancies in Females with Juvenile Idiopathic Arthritis (JIA) Who Were Exposed to Biologics and/or Methotrexate – Results from a Biologic Register

    Katrin Stüdemann1, Martina Niewerth1, Jens Klotsche1, Angela Zink2, Gerd Horneff3 and Kirsten Minden1,4, 1Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, 2German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, 3Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, 4Chidlrens´ hospital, Charité University Medicine, Berlin, Germany

    Background/Purpose JIA often continues into adult life and affects about 1 in 1,000 people of childbearing age. Little is known about the impact of JIA…
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