Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 395 • 2016 ACR/ARHP Annual Meeting
The Influence of Early Achievement of “Clinically Inactive Disease” or “Minimal Disease Activity” on Long-Term Disability Outcomes in JIA
Stephanie J.W.Shoop^1,2, Suzanne M.M. Verstappen³, Janet E. McDonagh⁴, Wendy Thomson^5,6, Kimme L. Hyrich^3,7 and CAPS, ¹Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ²The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ⁴Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁷Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Different definitions of clinically inactive disease (CID) for JIA have recently been shown to identify different groups of children. It is unclear whether long-term…
Abstract Number: 2039 • 2016 ACR/ARHP Annual Meeting
Assessing Barriers to Uveitis Screening in Patients with JIA: A Qualitative Study
Laura Ballenger¹, Kyla Driest² and Stacy P. Ardoin³, ¹Nationwide Children's Hospital, Columbus, OH, ²Rheumatology, Nationwide Children's Hospital, Columbus, OH, ³Pediatric & Adult Rheumatology, Ohio State University, Columbus, OH
Background/Purpose: Uveitis is a major complication in patients with juvenile idiopathic arthritis (JIA) can be completely asymptomatic until vision loss develops. In order to prevent ocular…
Abstract Number: 398 • 2016 ACR/ARHP Annual Meeting
Predictors of Clinical Remission with Etanercept in Pediatric Patients with Extended Oligoarticular, Enthesitis-Related Arthritis and Psoriatic Arthritis: Findings from the Clipper Study
Nicolino Ruperto¹, Alessandro Consolaro², Gerd Horneff¹, Rubén Burgos-Vargas¹, Tamas Constantin¹, Ivan Foeldvari¹, Jelena Vojinovic¹, Joke Dehoorne¹, Violeta Vladislava Panaviene¹, Gordana Susic¹, Valda Stanevicha¹, Katarzyna Kobusinska¹, Zbigniew Zuber³, Richard Mouy¹, Ingrida Rumba-Rozenfelde¹, Pavla Dolezalová¹, Chantal Job-deslandre⁴, Nico M Wulffraat¹, Ronald Pedersen⁵, Jack F Bukowski⁶, Tina Hinnershitz⁷, Bonnie Vlahos⁸ and Alberto Martini⁹, ¹Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ²Istituto Giannina Gaslini, Genoa, Italy, ³St Louis Children’s Hospital ODS Rheumatology and Neurology, Krakow, Poland, ⁴Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ⁵Department of Biostatistics, Pfizer, Collegeville, PA, ⁶Clinical Affairs, Pfizer, Collegeville, PA, ⁷Specialty Care MDG, Pfizer, Collegeville, PA, ⁸GIPB - Clinical Sciences, Pfizer, Collegeville, PA, ⁹PRINTO-IRCCS, Genoa, Italy
Background/Purpose: Etanercept (ETN) is approved in the EU for the treatment of children with juvenile idiopathic arthritis (JIA) categories of polyarticular, extended oligoarticular (eoJIA), enthesitis-related…
Abstract Number: 2408 • 2016 ACR/ARHP Annual Meeting
Severe Juvenile Arthritis Associated with a De Novo Gain-of-Function Germline Mutation in MYD88
Keith A. Sikora¹, Joshua R. Bennett¹, Zuoming Deng², Wanxia Li Tsai³, April Brundidge³, Fatemeh Navid³, Gerlinde Layh-Schmitt³, Eric Hanson³, Massimo G. Gadina⁴, Louis M. Staudt⁵, Thomas A. Griffin⁶ and Robert A. Colbert³, ¹Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Biodata Mining & Discovery, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁵National Cancer Institute, National Institutes of Health, Bethesda, MD, ⁶Levine Children’s Hospital at Carolinas Medical Center, Charlotte, NC
Background/Purpose: Myeloid differentiation primary response 88 (MyD88) is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-κB. Germline loss-of-function…
Abstract Number: 405 • 2016 ACR/ARHP Annual Meeting
Patterns of Medication Use in Children with Juvenile Idiopathic Arthritis: Results from the Childhood Arthritis & Rheumatology Research Alliance Registry
Sarah Ringold¹, Yukiko Kimura², Laura E. Schanberg³, Marc D. Natter⁴, Fenglong Xie⁵, Norman Ilowite⁶, Jason Jones⁷, Kelly Mieszkalski⁸, Timothy Beukelman⁹ and for the CARRA Registry Investigators, ¹Pediatrics, Seattle Children's Hospital, Seattle, WA, ²Hackensack University Medical Center, Hackensack, NJ, ³Pediatrics, Duke Medical Center, Durham, NC, ⁴Intelligent Health Labs, Children's Hospital Boston, Boston, MA, ⁵Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁶Division of Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ⁷Childhood Arthritis and Research Rheumatology Alliance (CARRA), Durham, NC, ⁸Childhood Arthritis and Rheumatology Research Alliance (CARRA), Durham, NC, ⁹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry is a multicenter, prospective observational study collecting data from children with rheumatic diseases in order…
Abstract Number: 2417 • 2016 ACR/ARHP Annual Meeting
High Dimensional Interrogation of the T Cell Immunome in Polyarticular Juvenile Idiopathic Arthritis Patients
Jing Yao Leong¹, Justin Tiong², Joo Guan Yeo^2,3, Liyun Lai¹, Phyllis Chen³, Loshinidevi D/O Thana Bathi³, Thaschawee Arkachaisri², Daniel J Lovell⁴ and Salvatore Albani^1,5, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁵Duke-National University of Singapore Medical School, Singapore, Singapore
Background/Purpose: Clinical management of polyarticular JIA with anti-TNF-alpha has been met with moderate success, with up to 50% of patients demonstrating clinically meaningful efficacy. Concerns…
Abstract Number: 406 • 2016 ACR/ARHP Annual Meeting
Adults with Juvenile Idiopathic Arthritis Are Not Adults with Rheumatoid Arthritis
Rayford R. June¹, Danielle Feger², Nicholas Longson³, Barbara E. Ostrov^4,5 and Nancy J. Olsen⁶, ¹Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ²Medicine/Rheumatology, Penn State College of Medicine, Hershey, PA, ³Johns Hopkins University, Baltimore, MD, ⁴Pediatrics, Penn State Hershey Medical Center, Hershey, PA, ⁵Pediatrics, Penn State Hershey Children's Hospital, Hershey, PA, ⁶Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) persisting into adulthood is associated with articular damage, increased disability and mortality. Approximately 100,000 polyarticular JIA patients will enter adult…
Abstract Number: 3114 • 2016 ACR/ARHP Annual Meeting
Cardiorespiratory Fitness in Children with Juvenile Idiopathic Arthritis Treated in the Biological Era Is Comparable with Controls- a Cross-Sectional Study
Kristine Risum¹, Elisabeth Edvardsen^2,3, Anne Marit Selvaag⁴, Oyvind Molberg⁴, Hanne Dagfinrud⁵ and Helga Sanner^4,6, ¹Department of Rehabilitation, Division of Orthopeadic Surgery, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway, Oslo, Norway, ³Department of Pulmonary Medicine, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁴Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁵Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ⁶Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Cardiorespiratory Fitness in Children with Juvenile Idiopathic Arthritis Treated in the Biological Era is Comparable with Controls- a Cross-Sectional Study Background/Purpose: Reduced cardiorespiratory fitness (CRF)…
Abstract Number: 407 • 2016 ACR/ARHP Annual Meeting
Comparability of Proxy, Adolescent and Adult Measures of Functional Ability in Adolescents with JIA
Stephanie J.W.Shoop^1,2, Kimme L. Hyrich^3,4, Suzanne M.M. Verstappen⁴, Wendy Thomson^5,6, Janet E. McDonagh⁷ and CAPS, ¹The University of Manchester, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Central Manchester University Hospitals NHS Foundation Trust and University of Manchester Partnership, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ³Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Genetics and Genomics,The University of Manchester, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ⁷Faculty of Medical and Human Sciences, Centre for MSK Research, Manchester, United Kingdom
Background/Purpose: It is unclear which tool should measure functional ability in adolescents with JIA. The proxy-completed Childhood Health Assessment Questionnaire (P-CHAQ) is completed on the…
Abstract Number: 3115 • 2016 ACR/ARHP Annual Meeting
Reconsidering the Juvenile Idiopathic Arthritis Core Set: How Patients and Caregivers Define Disease Activity
Jennifer R. Horonjeff¹, Susan Thornhill², Daniel B. Horton³, Jennifer N. Stinson⁴, Anjali Fortna⁵, Stephanie Luca⁶, Arlene Vinci⁷, Laura C. Marrow⁸, Emily L. Creek⁷, Meredith Riebschleger⁹, Alessandro Consolaro¹⁰, Jane Munro¹¹, Vibeke Strand¹², Clifton Bingham III¹³ and Esi Morgan¹⁴, ¹Rheumatology, Columbia University Medical Center, New York, NY, ²Thornhill Associates, Hermosa Beach, CA, ³Pediatrics, Division of Pediatric Rheumatology, Rutgers Robert Wood Johnson Medical School, Rutgers Biomedical and Health Sciences, New Brunswick, NJ, ⁴Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Columbia University Medical Center, New York, NY, ⁶The Hospital for Sick Children, Toronto, ON, Canada, ⁷Consumer Health, Arthritis Foundation, Atlanta, GA, ⁸Arthritis Foundation, Atlanta, GA, ⁹Pediatric Rheumatology & Health Services Research, University of Michigan, Ann Arbor, MI, ¹⁰Pediatria II - Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ¹¹Rheumatology, Royal Children's Hospital, Parkville, Australia, ¹²Stanford University School of Medicine, Palo Alto, CA, ¹³Divisions of Rheumatology and Allergy, Department of Medicine, Johns Hopkins University, Johns Hopkins University, Baltimore, MD, ¹⁴Pediatric Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: The current JIA Core Set (ACR Pediatric 30) contains items that should be assessed in clinical trials for children with JIA. It was developed…
Abstract Number: 410 • 2016 ACR/ARHP Annual Meeting
Sleep and Its Relationship to Pain and Disease Activity in Turkish Children and Adolescent with Juvenile Idiopathic Arthritis
Ela Tarakci¹, Saime Nilay Baydogan¹, Kenan Barut², Amra Adrovic², Sezgin Sahin² and Ozgur Kasapcopur³, ¹Istanbul University, Faculty of Health Science, Division of Physiotherapy and Rehabilitation, Istanbul, Turkey, ²Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, ³Department of Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey
Background/Purpose: Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritis of unknown cause, which begin before 16 years of…
Abstract Number: 411 • 2016 ACR/ARHP Annual Meeting
Evaluating Levels of Activity and Health-Related Quality of Life in a Cohort of Youth Athletes with Juvenile Idiopathic Arthritis
Tommy Gerschman¹, Jordan Raugust², Julia Brooks³, Nicole Johnson¹, Nadia Luca¹, Rebeka Stevenson¹, Heinrike Schmeling⁴, Paivi Miettunen¹ and Susanne Benseler¹, ¹Pediatrics, University of Calgary, Calgary, AB, Canada, ²Department of Pediatrics, University of Calgary, Calgary, AB, Canada, ³Pediatrics, Alberta Children's Hospital, Calgary, AB, Canada, ⁴Paediatrics, University of Calgary, Calgary, AB, Canada
Background/Purpose: Children with JIA are increasingly being encouraged to be physically active and are participating in organized and competitive sports as youth athletes. These youth…
Abstract Number: 416 • 2016 ACR/ARHP Annual Meeting
Uveitis Associated to Polyarticular Juvenile Idiopathic Arthritis
Ivan Foeldvari¹, Nicolino Ruperto¹, Daniel J Lovell², Gerd Horneff¹, Hans-Iko Huppertz³, Pierre Quartier⁴, Gabriele Simonini¹, Mareike Bereswill⁵, Jasmina Kalabic⁵, Alberto Martini¹ and Hermine I. Brunner², ¹PRINTO-IRCCS, Genova, Italy, ²PRCSG, Cincinnati, OH, ³PRINTO-IRCCS, Genoa, Italy, ⁴Hôpital Necker-Enfants Malades, Paris, France, ⁵AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany
Background/Purpose: Approximately 10-15% of patients (pts) with juvenile idiopathic arthritis (JIA) experience comorbid uveitis. The objective of this study is to explore events of uveitis and…
Abstract Number: 417 • 2016 ACR/ARHP Annual Meeting
Use of Tumor Necrosis Factor-α Inhibitors in Pediatric HLA-B27-Associated Uveitis
Bessie Frias¹, Courtney McCracken², Kirsten Jenkins³, Janet Figueroa⁴, Anna Tramposch¹, Steven Yeh⁵, Purnima Patel⁴, Carolyn Drews-Botsch⁶, Sampath Prahalad^7,8 and Sheila Angeles-Han^2,7, ¹Emory University, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory University School of Medicine, Atlanta, GA, ⁵Ophthalmology, Emory University School of Medicine, Atlanta, GA, ⁶Epidemiology, Emory University School of Public Health, Atlanta, GA, ⁷Children's Healthcare of Atlanta, Atlanta, GA, ⁸Pediatric Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: Pediatric HLA-B27-associated uveitis is a common form of non-infectious uveitis (NIU) that can lead to ocular complications and vision loss. Methotrexate (MTX) is the…
Abstract Number: 947 • 2016 ACR/ARHP Annual Meeting
A Multi-Center, Open-Label Study to Assess the Pharmacokinetics, Efficacy and Safety of Certolizumab Pegol in Children and Adolescents with Moderately to Severely Active Polyarticular-Course Juvenile Idiopathic Arthritis: Week 24 Results
Hermine I. Brunner¹, Nicolino Ruperto², Vladimir Keltsev³, Ekaterina Alexeeva⁴, Carlos Abud-Mendoza⁵, Heinrike Schmeling⁶, María del Rocío Maldonado-Velázquez⁷, Nadina Rubio-Pérez⁸, Marina Stanislav⁹, Vyacheslav Chasnyk¹⁰, Diane Brown¹¹, Michael Henrickson¹, Daniel Kingsbury¹², C. Egla Rabinovich¹³, Andrew Zeft¹⁴, Earl Silverman¹⁵, Maggie Wang¹⁶, Philippa Charlton¹⁶, Rocio Lledo-Garcia¹⁷, Laura Shaughnessy¹⁶, Daniel J. Lovell¹ and Alberto Martini², ¹PRCSG, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²PRINTO, Istituto Gaslini, Genoa, Italy, ³Togliatti City Clinical Hospital №5, Togliatti, Russian Federation, ⁴Children's Health of RAMS and IM Sechenov First Moscow State Medical University, Moscow, Russian Federation, ⁵Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ⁶Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ⁷Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico, ⁸Universidad Autónoma de Nuevo León, Nuevo León, Mexico, ⁹Research Rheumatology Institute V.A. Nassonova, Moscow, Russia, ¹⁰St Petersburg State Pediatric Medical Academy, St Petersburg, Russian Federation, ¹¹Division of Rheumatology, Children's Hospital of Los Angeles and University of Southern California, Los Angeles, CA, ¹²Pediatric Rheumatology, Randall Children's Hospital at Legacy Emanuel, Portland, OR, ¹³Duke University Medical Center, Durham, NC, ¹⁴Cleveland Clinic, Pediatric Rheumatology, Cleveland, OH, ¹⁵Hospital for Sick Children, Toronto, ON, Canada, ¹⁶UCB Pharma, Raleigh, NC, ¹⁷UCB Pharma, Slough, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) often requires biologic medication to control polyarticular disease courses. This study assesses the pharmacokinetics (PK), efficacy and safety of certolizumab…

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