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Abstracts tagged "juvenile idiopathic arthritis (JIA) and synovial cells"

  • Abstract Number: 380 • ACR/ARHP Annual Meeting 2016

    Linear Discriminant Analysis of Cultured Fibroblast-like Synoviocytes Identifies 6 Candidate Genes Which Predict Extended Course in Juvenile Idiopathic Arthritis

    AnneMarie Brescia1, Megan Simonds2, Suzanne McCahan3, Tim Bunnell3, Kathleen E. Sullivan4 and Carlos D. Rosé1, 1Pediatric Rheumatology, Thomas Jefferson University/ AI duPont Hospital for Children, Wilmington, DE, 2Nemours, Nemours Biomedical Research, Wilmington, DE, 3Nemours Biomedical Research, Wilmington, DE, 4Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: The goal of this project is the identification of informative synovial biomarkers to predict which children with oligoarticular juvenile idiopathic arthritis (JIA) will have…
  • Abstract Number: 2467 • ACR/ARHP Annual Meeting 2015

    Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis

    Ian D. Ferguson1, Patricia Griffin2, Hiroshi Yano3, Joshua J. Michel2, Jeffrey A. Dvergsten4, Sarah L. Gaffen5, Margalit E. Rosenkranz1, Daniel A. Kietz1 and Abbe N. Vallejo1, 1Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, 2Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Department of Pediatrics, Duke University Medical Center, Durham, NC, 5Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…

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