Abstracts tagged "juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA)"

Abstract Number: 2416 • 2016 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Peptides in Patients with Juvenile Idiopathic Arthritis and Rheumatoid Arthritis: Shared Expression of the Inherently Autoreactive 9G4 Idiotype
Hannah Peckham¹, Lauren Bourke¹, Anna Radziszewska¹, Maria J. Leandro², Debajit Sen¹, Geraldine Cambridge² and Yiannis Ioannou¹, ¹Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Rheumatoid factor (RF) positive polyarticular JIA (RF+ve pJIA) frequently progresses into adulthood with a clinical phenotype that ressembles rheumatoid arthritis (RA). Antibodies to cyclic…
Abstract Number: 1940 • 2015 ACR/ARHP Annual Meeting
A Circulating Reservoir of Pathogenic-like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment
Roberto Spreafico^1,2, Maura Rossetti^1,2, Jorg van Loosdregt¹, Carol A. Wallace³, Margherita Massa⁴, Silvia Magni-Manzoni⁵, Marco Gattorno⁶, Alberto Martini⁷, Daniel Lovell^8,9 and Salvatore Albani^2,10, ¹Sanford-Burnham Medical Research Institute, La Jolla, CA, ²SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³Seattle Children’s Hospital and Research Institute, Seattle, WA, ⁴Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁶Instituto Giannina Gaslini and University of Genova, Genova, Italy, ⁷Istituto G. Gaslini, Universita' di Genova, Genova, Italy, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
Background/Purpose: Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand…
Abstract Number: 400 • 2014 ACR/ARHP Annual Meeting
Clinical Utility of 14-3-3η in the Evaluation of Inflammatory Arthritis
Lance Feller¹, Paul Tuttle IV² and Terry L. Moore³, ¹Rheumatology, Saint Louis University, St. Louis, MO, ²Rheumatology, Saint Louis University, Saint Louis, MO, ³Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
Abstract Number: 2197 • 2013 ACR/ARHP Annual Meeting
High Titer IgG Anti-Cyclic Citrullinated Peptide Antibodies Are Associated With Joint Destruction In Juvenile Idiopathic Arthritis Patients
Brooke Gilliam, Lance Feller and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies have been identified as an important indicator of destructive disease in juvenile idiopathic arthritis (JIA), as is the…
Abstract Number: 2649 • 2012 ACR/ARHP Annual Meeting
Trends in US Arthroplasty Rates 1991-2005: Patients with Inflammatory Arthritis Continue to Require Joint Replacement
Christina Mertelsmann-Voss¹, Ting Jung Pan², Stephen L. Lyman³, Mark P. Figgie⁴ and Lisa A. Mandl⁵, ¹Pediatric Rheumatology, Hospital for Special Surgery, Cornell University, New York, NY, ²Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Research, Hospital Special Surgery, New York, NY, ⁴Orthopedics, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, Hospital for Special Surgery, New York, NY
Background/Purpose: Overall rates of total joint replacement surgeries (TJR) have increased dramatically over the past decades. By contrast, TJR rates among patients with rheumatoid arthritis…

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