Abstracts tagged "juvenile idiopathic arthritis (JIA) and pathogenesis"

Abstract Number: 953 • 2017 ACR/ARHP Annual Meeting
Persistence of Pathogenic CD4 Memory T Cells Revealed through Cytometry Time of Flight in Juvenile Idiopathic Arthritic Patients with Disease Resurgence upon Withdrawal of Anti-TNFA Biologics
Jing Yao Leong¹, Joo Guan Yeo², Phyllis Chen³, Liyun Lai⁴, Fauziah Ally⁵, Loshinidevi D/O Thana Bathi³, Justin Hung Tiong Tan², Thaschawee Arkachaisri², Femke van Wijk⁶, Salvatore Albani⁴, Daniel J Lovell⁷ and Gerdien Mijnheer⁸, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ⁴SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ⁵STIIC, SingHealth Translational Immunology and Inflammation Centre, Singapore, Singapore, ⁶University Medical Center Utrecht, Utrecht, Netherlands, ⁷Rheumatology, PRCSG - Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁸1Laboratory of Translational Immunology, Department of Paediatric Immunology, , The Netherlands, University Medical Centre Utrecht, Wilhelmina Children’s Hospital, Utrecht, Netherlands
Background/Purpose: Treatment of polyarticular JIA with anti-TNFA biologics has experienced significant success, with up to 80% of patients demonstrating clinically meaningful efficacy. Yet concerns regarding…
Abstract Number: 1744 • 2017 ACR/ARHP Annual Meeting
Transciptome Profile of Inflammation Inducted Circulating Effector and Regulatory T Cells Is Dominated By HLA-DR Pivoted Functional Networks in Active Juvenile Idiopathic Arthritis Patients
Jing Yao Leong¹, Salvatore Albani², Pavanish Kumar², Joo Guan Yeo³, Phyllis Chen¹, Sharifah Nur Hazirah², Camillus Chua², Suzan Saidin², Justin Hung Tiong Tan³, Thaschawee Arkachaisri³, Alberto Martini⁴, Marco Gattorno⁵ and Alessandro Consolaro⁶, ¹Singhealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ²SingHealth Translational Immunology and Inflammation Centre (STIIC), Duke-NUS Medical School, Singapore, Singapore, ³Rheumatology and Immunology Service, KK Women's and Children's Hospital, Singapore, Singapore, ⁴PRINTO Coordinating Centre, Genoa, Italy, ⁵Pediatric Rheumatology, G. Gaslini Institute, Genoa, Italy, ⁶Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: We have previously identified two dichotomous CD4 pathogenic subsets in both T effector (CPLs: Circulating pathogenic like lymphocytes) and T regulatory (iaTreg: inflammation associated…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].