Abstracts tagged "Juvenile idiopathic arthritis (JIA) and major histocompatibility complex (MHC)"

Abstract Number: 938 • 2017 ACR/ARHP Annual Meeting
A Germline Macrophage Activation Syndrome-Associated Nlrc4 Mutation Causes Chronic, Systemic, Non-Hematopoietic IL-18 Elevation and Intestinal MHC-II Upregulation
Eric Weiss¹, Corinne Schneider² and Scott Canna³, ¹RK Mellon Institute, Children’s Hospital of Pittsburgh, Pittsburgh, PA, ²Pediatrics, Children's Hospital Pittsburgh, Pittsburgh, PA, ³NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Patients prone to the development of Macrophage Activation Syndrome (MAS) can have extreme and often chronic elevation in the pro-inflammatory cytokine interleukin-18 (IL-18). In…
Abstract Number: 2199 • 2013 ACR/ARHP Annual Meeting
Analysis Of The MHC Region In a Large Cohort Of Juvenile Idiopathic Arthritis Cases Identifies Independent Effects At HLA-DRB1
Anne Hinks¹, Joanna Cobb¹, Buhm Han^2,3, Miranda C. Marion⁴, Marc Sudman⁵, Paul Martin¹, John F. Bohnsack⁶, Lucy R. Wedderburn⁷, Johannes Peter Haas⁸, Paul de Bakker², Carl D. Langefeld⁹, Soumya Raychaudhuri², Sampath Prahalad¹⁰, Susan D. Thompson¹¹ and Wendy Thomson¹, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, ⁴Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ⁵Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatriacs, University of Utah, Salt Lake City, UT, ⁷Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁸German Centre for Rheumatology in Children and Young People, Garmisch-Partenkirchen, Germany, ⁹Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ¹⁰Emory University School of Medicine, Atlanta, GA, ¹¹Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common arthritic disease of childhood and is caused by a combination of genes and environment. In the…

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