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Abstracts tagged "juvenile arthritis and therapeutic targeting"

  • Abstract Number: 933 • ACR/ARHP Annual Meeting 2015

    DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis

    Nirit Mor-Vaknin1, Anjan K. Saha2, Maureen Legendre1, Carmelo Carmona-Rivera3, M. Asif Amin4, Bradley J. Rabquer5, Marta J. Gonzalez-Hernandez6, Julie M. Jorns7, Srilakshmi Yalavarthi8, Smriti Mohan9, Dave Pai10, Kristine Angevine11, Barbara Adams12, Jason S. Knight8, Alisa E. Koch13,14,15, David Fox14, Dave Engelke16, Mariana J. Kaplan17 and David Markovitz4, 1Infectious Diseases, University of Michigan, Ann Arbor, MI, 2Medical School, University of Michigan, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Internal Medicine, University of Michigan, Ann Arbor, MI, 5Albion College, Ann Arbor, MI, 6Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, 7Pathology, University of Michigan, Ann Arbor, MI, 8Division of Rheumatology, University of Michigan, Ann Arbor, MI, 9Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, 10Scripps Research Institute, San Diego, CT, 11Appistry, Inc, St. Louis, MO, 12Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, 13VA Medical Service, Ann Arbor, MI, 14Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 15Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, 16Biochemistry, University Michigan, Ann Arbor, MI, 17Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD

    Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…

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