ACR Meeting Abstracts

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Abstracts tagged "joint destruction"

  • Abstract Number: 2114 • 2012 ACR/ARHP Annual Meeting

    Joint Damage Progression in Rheumatoid Arthritis: Role of the HLA-DRB1 Shared Epitope and Anti-CCP

    Jose Felix Restrepo1, Inmaculada del Rincon1, Roy W. Haas2, Daniel F. Battafarano3 and Agustin Escalante2, 1Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Medicine / MCHE-MDR, Brooke Army Medical Ctr, San Antonio, TX

    Background/Purpose: The HLA-DRB1 shared epitope (SE) and antibodies to cyclic citrullinated peptides (anti-CCP) are important to the susceptibility to rheumatoid arthritis (RA), and are thought…
  • Abstract Number: 2118 • 2012 ACR/ARHP Annual Meeting

    Validation of Prognostic Biomarkers for RA: Testing of 14-3-3 Eta According to the Omeract Soluble Biomarker Criteria

    Walter P. Maksymowych1, Désirée van der Heijde2, R. Landewe3, George A. Wells4, Joan M. Bathon5, Clifton O. Bingham III6, Vivian P. Bykerk7, Mikkel Ostergaard8, Hilde B. Hammer9, Maarten Boers10, Paul Peter Tak11, Oliver M. FitzGerald12, Christopher T. Ritchlin13, Dafna D. Gladman14, Philip J. Mease15, Dirkjan van Schaardenburg16, Marina Backhaus17, Bernard Combe18, Gianfranco Ferraccioli19 and Anthony Marotta20, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 4Epidemiology & Community Med, Univ of Ottawa Faculty of Med, Ottawa, ON, Canada, 5Columbia University, New York, NY, 6Rheumatology, Johns Hopkins University, Baltimore, MD, 7Rheumatology, Hospital for Special Surgery, New York, NY, 8Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, 9Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 10Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, 11Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 12Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 13Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 14Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 15Swedish Rheumatology Research Group, Seattle, WA, 16Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 17Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, 18Rheumatology, Hopital Lapeyronie, Montpellier, France, 19Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 20Augurex Life Sciences Corp, North Vancouver, BC, Canada

    Background/Purpose: The OMERACT soluble biomarker sub-committee has published validation criteria related to truth, discrimination and feasibility for biomarkers reflecting structural damage1. The large majority of…
  • Abstract Number: 2092 • 2012 ACR/ARHP Annual Meeting

    No Significant Effect of Hepatitis B Virus Infection On Disease Activity, Synovitis or Joint Destruction in Rheumatoid Arthritis

    Chan Juan Zou, Yan Hua Li, Ying Qian Mo, Lang Jing Zhu, Dong Hui Zheng, Jian Da Ma, Xia Ouyang and Lie Dai, Division of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

    Background/Purpose: The prevalence of chronic hepatitis B virus (HBV) infection is high in China. 4% patients with HBV infection can present with polyarthritis and positive…
  • Abstract Number: 1849 • 2012 ACR/ARHP Annual Meeting

    Value of Matrices Developed to Identify Early Rheumatoid Arthritis Patients with Rapid Radiographic Progression Despite Methotrexate Therapy: A Comparison of Their Performance in the Early Rheumatoid Arthritis Espoir Cohort

    Bruno Fautrel1, Benjamin Granger2, Bernard Combe3, Francis Guillemin4, Alain Saraux5 and Xavier Le Loët6, 1Rheumatology / GRC08-EEMOIS, APHP-Pitie Salpetriere Hospital / UPMC, Paris, France, 2Biostatistics - GRC08-EEMOIS, Université Pierre et Marie Curie - Paris 6 ; AP-HP, Paris, France, 3CHU Lapeyronie, Montpellier, France, 4Hopitaux de Brabois, Nancy, France, 5Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France, 6Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France

    Background/Purpose: Rapid radiographic progression (RRP) – i.e., increase of the Sharp/van der Heijde score (vSHS) ≥ 5 points during the 1st year – is a…
  • Abstract Number: 1040 • 2012 ACR/ARHP Annual Meeting

    Combined High-Resolution Single Photon Emission Computed Tomography and Magnetic Resonance Imaging for Therapy Monitoring in Rheumatoid Arthritis

    Philipp Sewerin1, Christian Buchbender2, Katalin Mattes-György3, Falk Miese2, Hans-Jörg Wittsack2, Christof Specker4, Gerald Antoch2, Matthias Schneider5, Axel Scherer2 and Ben Ostendorf1, 1Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, 2Diagnostic and Interventional Radiology, Heinrich-Heine-University, Düsseldorf, Germany, 3Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany, 4Department of rheumatology and clinical immunology, Hospital Essen Sued, Essem, Germany, 5Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany

    Background/Purpose: To evaluate whether combined multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labelled disphosphonates (Tc99m-DPD) and magnetic resonance imaging (MRI) detect changes in inflammation…
  • Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting

    Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis

    Shawn M. Rose1, Harris R. Perlman2, Emily Alex Waters3 and Thomas Meade3, 1Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Chemistry of Life Processes Institute, Northwestern University, Evanston, IL

    Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally.  Magnetic…
  • Abstract Number: 894 • 2012 ACR/ARHP Annual Meeting

    Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts

    A. Krabben1, A. G. Wilson2, R. Knevel1, A. Zhernakova3, E. Brouwer3, E. Lindqvist4, T. Saxne4, G. Stoeken-Rijsbergen1, J. A. B. van Nies1, D. P. C. de Rooy1, T.W.J. Huizinga1, B. P. C. Koeleman5, R. E. M. Toes1, P. K. Gregersen6 and A. H. M. van der Helm-van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Infection & Immunity, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, 4Rheumatology, Lund University, Lund, Sweden, 5Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY

    Background/Purpose: The severity of RA is reflected by the severity of radiological joint destruction. It is highly variable between patients and up to 58% of…
  • Abstract Number: 895 • 2012 ACR/ARHP Annual Meeting

    Transcriptomics of Synovial Tissue of Early Human (CHECK) and Experimental OA Identify Pathways Associated with Cartilage Damage

    Arjen B. Blom1, Peter L.E.M. van Lent2, Martijn H. van den Bosch1, Hans Cats3, Peter M. van der Kraan1 and Wim B. van den Berg4, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Many osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. Mechanisms through which synovial activation contributes to the joint pathology that…
  • Abstract Number: 809 • 2012 ACR/ARHP Annual Meeting

    Ultrasonography Predicts Achievement of Deeper Remission After DAS28-Based Clinical Remission of Rheumatoid Arthritis

    Ryusuke Yoshimi1, Maasa Hama1, Daiga Kishimoto1, Reikou Watanabe1, Takeaki Uehara2, Yukiko Asami1, Atsushi Ihata1, Atsuhisa Ueda1, Mitsuhiro Takeno1 and Yoshiaki Ishigatsubo1, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Department of Rheumatology, Chigasaki Municipal Hospital, Chigasaki, Japan

    Background/Purpose: Although clinical remission is an agreeable goal of treatment in rheumatoid arthritis (RA), the definition is still controversial. Indeed, progressive structural damage is often…
  • Abstract Number: 733 • 2012 ACR/ARHP Annual Meeting

    Intra-Articular Injection of Adipose-Derived Stem Cells Inhibits Activation of the Synovium and Protects Against Cartilage Damage and Enthesophyte Formation in Murine Experimental Osteoarthritis

    Peter L.E.M. van Lent1, Menno C. ter Huurne2, Arjen B. Blom3, Rik Schelbergen3, Louis Casteilla4, Thomas Vogl5, Johannes Roth5, Roxane Blattes4, Christian Jorgensen6 and Wim B. van den Berg7, 1Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4STROMALab UPS/CNRS UMR5273, INSERM U1031, Toulouse, France, 5Institute of Immunology, University of Muenster, Munster, Germany, 6Department of therapy & Immuno-Rhumatology, Hospital Lapeyronie, Montpellier, France, 7Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: OA lesions are treated with mesenchymal stem cells aiming to enhance tissue repair by transformation to eg. chondrocytes.  Recently it has been shown that…
  • Abstract Number: 370 • 2012 ACR/ARHP Annual Meeting

    Characteristic of the Japanese Patients with Rheumatoid Arthritis (RA) of Rapid Radiographic Progression (RRP) Treated with Synthetic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Daily Practice: A Large-Scale Prospective Longitudinal Cohort Study (the 1st report of Apple Survey)

    Akitomo Okada1, Atsushi Kawakami2, Takaaki Fukuda3, Toshihiko Hidaka4, Tomonori Ishii5, Yukitaka Ueki6, Takao Kodera7, Munetoshi Nakashima8, Yuichi Takahashi9, Seiyo Honda10, Yoshiro Horai2, Tomohiro Koga1, Ryu Watanabe11, Hiroshi Okuno12 and Katsumi Eguchi13, 1Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Center for Rheumatic Diseases, Kurume University Medical Center, Kurume, Japan, 4Zenjinkai Shimin-No-Mori Hospital, Miyazaki, Japan, 5Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 6Sasebo Chuo Hospital, Sasebo, Japan, 7Tohoku Kosei Nenkin Hospital, Sendai, Japan, 8Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, 9Yu Family Clinic, Sendai, Japan, 10Kurume University School of Medicene, Kurume, Japan, 11Department of Hematology and Rheumatology, Tohoku University Hospital, Sendai, Japan, 12Tohoku University Hospital, Sendai, Japan, 13Sasebo City General Hospital, Sasebo, Nagasaki, Japan

    Background/Purpose: There has been few epidemiological report of longitudinal radiographic progression in rheumatoid arthritis (RA) patients captured in daily practice. In 20 related-centers of the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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