Abstracts tagged "joint damage"

Abstract Number: 977 • 2015 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Active- and Placebo-Controlled Phase 3 Study of Efficacy and Safety of Ixekizumab, Adalimumab, and Placebo Therapy in Patients Naïve to Biologic Disease Modifying Anti-Rheumatic Drugs with Active Psoriatic Arthritis
Philip J. Mease¹, Désirée van der Heijde², Christopher T. Ritchlin³, Raquel Cuchacovich^4,5, Catherine L. Shuler⁵, Chin H. Lee⁵, Suvajit Samanta⁵, Chen-Yen Lin⁵, Dafna D. Gladman⁶ and Harald Vangerow⁵, ¹Department of Rheumatology, Swedish Medical Center and University of Washington, Seattle, WA, ²Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands, ³Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁴School of Medicine, Rheumatology Division, Indiana University, Indianapolis, IN, ⁵Eli Lilly and Company, Indianapolis, IN, ⁶Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a chronic immune-mediated inflammatory disease associated with psoriasis which includes peripheral arthritis, enthesitis, dactylitis, and spondylitis manifestations. Ixekizumab, under investigation…
Abstract Number: 1305 • 2015 ACR/ARHP Annual Meeting
Prevalence of MR-Detected Ramris-Defined Erosions in the General Population
L. Mangnus¹, H.W. van Steenbergen², M. Reijnierse³ and A.H.M. van der Helm- van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The diagnostic value of Magnetic Resonance (MR) imaging for Rheumatoid Arthritis (RA) is undetermined. The main value of MR is its sensitive depiction of…
Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting
Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?
Matthew Jessome¹, Michael Tomizza¹, Karen A. Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
Abstract Number: 1325 • 2015 ACR/ARHP Annual Meeting
Age Effects Joint Space Narrowing in Early Active Rheumatoid Arthritis Patients
Xanthe M.E. Matthijssen¹, Gülsah Akdemir¹, Iris M. Markusse², Yvonne P. Goekoop-Ruiterman³, K. Huub Han⁴, Annekoos L. Huidekoper⁵, Pit J.S.M. Kerstens⁶, Willem F. Lems⁷, T. W. J. Huizinga¹ and Cornelia F. Allaart¹, ¹Rheumatology, LUMC, Leiden, Netherlands, ²LUMC, Leiden, Netherlands, ³Rheumatology, HAGA hospital, The Hague, Netherlands, ⁴Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ⁵Rheumatology, Bronovo hospital, The Hague, Netherlands, ⁶Department of Rheumatology, Reade, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Joint space narrowing (JSN) and erosions are the major radiologic markers of radiographic progression in rheumatoid arthritis (RA), as scored by the Sharp/van der…
Abstract Number: 1716 • 2015 ACR/ARHP Annual Meeting
Prevalence of Joint Symptoms and Frequency of Joint Exams for Patients with Plaque Psoriasis without Confirmed Psoriatic Arthritis: A US Analysis
Tatiana Makhinova¹, Robert Wood², Derek Tang³, James Piercy², Steve Lobosco⁴, Bradley S. Stolshek⁵ and David J. Harrison⁵, ¹College of Pharmacy, University of Texas at Austin, Austin, TX, ²Adelphi Real World, Macclesfield, United Kingdom, ³Amgen, Inc., Thousand Oaks, CA, ⁴Adelphi Real World Ltd., Macclesfield, United Kingdom, ⁵Amgen Inc., Thousand Oaks, CA
Background/Purpose: Due to the high prevalence of PsA among patients with PsO,1 rheumatologists and dermatologists should recognize early signs and symptoms of joint involvement among…
Abstract Number: 2587 • 2015 ACR/ARHP Annual Meeting
CRP and 14-3-3η Are Each Associated with Joint Damage Progression, Their Titres Do Not Correlate and Are Better Predictors of Progression Together Than Alone
Gilles Boire^1,2, Nathalie Carrier³, Artur de Brum-Fernandes^1,4, Patrick Liang^1,4, Ariel Masetto^2,5, Yuan Gui⁶, Jane Savill⁶, Sara Michienzi⁶, Henri Ménard⁷, Walter Maksymowych⁸ and Anthony Marotta⁶, ¹Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, ³Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ⁶Augurex Life Sciences Corp., Vancouver, BC, Canada, ⁷MSK Research Axis, McGill University Health Center Research Institute, Montreal, QC, Canada, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: As a marker of inflammation and an acute phase reactant, C-reactive protein (CRP) is routinely used in clinical practice and in RA classification criteria.…
Abstract Number: 3098 • 2015 ACR/ARHP Annual Meeting
Synovial Lymphocytic Aggregates Associate with Highly Active RA and Predict Erosive Disease at 12 Months: Results from the Pathobiology of Early Arthritis Cohort
Maria DiCicco¹, Frances Humby¹, Stephen Kelly², Rebecca Hands¹, nora ng³, Arti Mahto³, Illias Lazarou³, Vidalba Rocher¹, Lu Zou³, Michele Bombardieri⁴, Christopher Buckley⁵, A.H.M. van der Helm- van Mil⁶, Robert B.M. Landewé⁷, Désirée van der Heijde⁸, Iain B. McInnes⁹, Peter C. Taylor¹⁰ and Costantino Pitzalis¹¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ²William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ³William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, ⁴Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ⁵University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷University of Amsterdam and Atrium Medical Center, Amsterdam, Netherlands, ⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ¹⁰Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Botnar Research Centre, Oxford, United Kingdom, ¹¹Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom
Background/Purpose: The inflammatory cell infiltrate in RA synovium has been recognised to organise into lymphocytic aggregates (Ags) with data to suggest that these structures are…
Abstract Number: 105 • 2015 ACR/ARHP Annual Meeting
Analysis of the Association of PTGER4 Gene Variants with Radiological Joint Damage in Rheumatoid Arthritis
Luis Rodriguez-Rodriguez^1,2, J. Ivorra-Cortes³, Francisco David Carmona⁴, Javier Martín⁵, Alejandro Balsa⁶, H.W. van Steenbergen⁷, A. H. M. van der Helm- van Mil⁸, Isidoro González-Alvaro⁹ and Benjamín Fernández-Gutiérrez¹⁰, ¹Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain, ²Hospital Clínico San Carlos, Department of Rheumatology, Madrid, Spain, ³Rheumatology, University Hospital la Fe, Valencia, Spain, ⁴Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ⁵Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ⁶Rheumatology, La Paz University Hospital-Rheumatology Department, Madrid, Spain, ⁷Leiden University Medical Center, Leiden, Netherlands, ⁸Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain, ¹⁰Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
Background/Purpose: PTGER4(prostaglandin E receptor 4) is implicated in immune regulation and bone metabolism. The aim of this study was to analyze the role of single…
Abstract Number: 119 • 2015 ACR/ARHP Annual Meeting
Triage in Chronic Rheumatic Diseases: Quantitative Physician Estimates for Inflammation (Reversible), Damage (Irreversible), and Distress in Patients with Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia Seen in Usual Care
Isabel Castrejón¹, Kathryn A. Gibson², Ruchi Jain¹, Annie Huang¹, Joel A. Block³ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Liverpool, Australia, ³Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of a patient’s global status (DOCGL) often is most often the most efficient of all 7 rheumatoid arthritis (RA) core data…
Abstract Number: 1592 • 2014 ACR/ARHP Annual Meeting
Ability of Clinical Variables to Predict Radiographic Damage in Psoriatic Arthritis
Vinod Chandran¹, Arane Thavaneswaran², Richard J. Cook³ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada
Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis associated with psoriasis that leads to progressive joint damage. Biomarkers in addition to clinical features may help…
Abstract Number: 1568 • 2014 ACR/ARHP Annual Meeting
Joint Damage Is Not Associated with Smoking Status in Patients with Psoriatic Arthritis
Hernán Maldonado-Ficco¹, Arane Thavaneswaran², Vinod Chandran² and Dafna D. Gladman², ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: The association between smoking and radiographic progression has been established in axial spondyloarthritides and rheumatoid arthritis (RA) but this association has not been established…
Abstract Number: 1379 • 2014 ACR/ARHP Annual Meeting
Studies on Ageing and the Severity of Radiographic Joint Damage in Rheumatoid Arthritis
L. Mangnus¹, H.W. van Steenbergen¹, E. Brouwer², E. Lindqvist³, M. Reijnierse⁴, P.K. Gregersen⁵, S. M. Rantapää-Dahlqvist⁶, D. M. van der Heijde¹ and A. H. M. van der Helm- van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology, Lund University, Lund, Sweden, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵The Feinstein Institute for Medical Research, Manhasset, NY, ⁶Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose: The Western population is getting older; consequently the proportion of elderly persons presenting with Rheumatoid Arthritis (RA) is increasing. We studied whether age is…
Abstract Number: 1368 • 2014 ACR/ARHP Annual Meeting
Are Tender Joints Better Than Synovitis to Predict Structural Damage in Rheumatoid Arthritis?
Peter Cheung¹, Karine Mari², Valerie Devauchelle³, Jacques Bentin⁴, Sandrine Jousse-Joulin⁵, Maria-Antonietta d'Agostino⁶, Gérard Chales⁷, Isabelle Chary-Valckenaere⁸, Fabien Etchepare⁹, Philippe Gaudin¹⁰, Xavier Mariette¹¹, Alain Saraux¹² and Maxime Dougados¹³, ¹Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, ²RCT, Lyon, France, ³Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁴Rheumatology, CHU-Brugmann, Brussels, Belgium, ⁵Rheumatology, CHU Brest, Brest, France, ⁶Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁷Dept of Rheumatology, CHR - Hopital Sud, Rennes, France, ⁸Rheumatology, Nancy University Hospital, Nancy, France, ⁹AP-HP, La Pitié-Salpétrière Hospital, Rheumatology Department, Paris-VI University, Paris, France, ¹⁰Rhumatologie, Hopital Sud Grenoble, Echirolles, France, ¹¹Paris-Sud University, Paris, France, ¹²Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France, ¹³Université Paris René Descartes and Hôpital Cochin, Paris, France
Background/Purpose: Longitudinal studies indicate that synovitis can predict subsequent structural damage in rheumatoid arthritis (RA) but the clinical relevance of tenderness is unclear. The aim…
Abstract Number: 1172 • 2014 ACR/ARHP Annual Meeting
Assessing the Validity and Reliability of a Novel MRI Semi-Automated Algorithm for Quantifying Bone Loss in the Hand
Matthew Jessome¹, Isabel Rodrigues², Michael Tomizza², Joshua Barbosa², Melissa XP. Koh¹, Karen Beattie³, William G. Bensen³, Raja Bobba³, Alfred Cividino³, Patrick D. Emond³, Karen Finlay⁴, Chris Gordon³, Lawrence Hart³, George Ioannidis³, Erik Jurriaans⁴, Maggie Larche³, Arthur Lau³, Naveen Parasu⁴, Ruben Tavares³, Stephen Tytus³, Hao Wu² and Jonathan D. Adachi^2,3, ¹Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ⁴Radiology, Hamilton Health Sciences, Hamilton, ON, Canada
Background/Purpose Efficient and accurate evaluation of erosive damage to the MCP joints in RA patients is desirable in both clinical trials and clinical practice. The…
Abstract Number: 1050 • 2014 ACR/ARHP Annual Meeting
A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation
Clare C. Cunningham¹, Emma M. Corr¹, Geraldine M. McCarthy² and Aisling Dunne¹, ¹School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ²Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…

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