Abstracts tagged "joint damage"

Abstract Number: 2300 • 2017 ACR/ARHP Annual Meeting
Predictive Value of Magnetic Resonance Imaging in Patients with Juvenile Idiopathic Arthritis in Clinical Remission
Clara Malattia¹, Marta Mazzoni Sr.², Stefania Viola Sr.², Angela Pistorio³, Francesca Magnaguagno⁴, Alessia Urro Jr.², Angelo Ravelli⁵ and Alberto Martini⁶, ¹Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genova, Italy, ³Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, ⁴UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, ⁵University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, ⁶Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: MRI studies on RA revealed that subclinical synovitis is common in patients in clinical remission and it is responsible for structural damage progression. MRI-detected…
Abstract Number: 2458 • 2017 ACR/ARHP Annual Meeting
Tocilizumab Inhibits Progression of Erosive Joint Damage in Early Rheumatoid Arthritis More Effectively Than Step-up Methotrexate Therapy
Xavier M Teitsma¹, Johannes WG Jacobs¹, Paco MJ Welsing², Attila Pethö-Schramm³, Michelle EA Borm⁴, Jacob M. van Laar⁵, Floris PJ Lafeber⁵ and Johannes W.J. Bijlsma², ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³F. Hoffmann-La Roche, Basel, Switzerland, ⁴Beneluxlaan 2a, Roche Nederland BV, Woerden, Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: In early rheumatoid arthritis (RA), starting therapy as soon as possible is important to reduce disease activity and preserve the joints. With application of…
Abstract Number: 382 • 2017 ACR/ARHP Annual Meeting
Radiological Features Identified in the Hands of Children with Down Syndrome and Inflammatory Arthritis
Charlene Foley¹, Emma Jane Mac Dermott¹, Aisling Snow² and Orla G Killeen¹, ¹National Centre for Paediatric Rheumatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland, ²Radiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland
Background/Purpose: Down’s Arthritis (DA) is an inflammatory joint condition affecting children with Down syndrome (DS). It is 18-21 times more common than JIA in the…
Abstract Number: 429 • 2017 ACR/ARHP Annual Meeting
Repair of Joint Damage Is Rare in Newly Diagnosed Rheumatoid Arthritis Patients and Appears Not to Relate to Previous Suppression of Inflammation
Joy A. van der Pol¹, Gulsah Akdemir¹, Marianne van den Broek¹, Linda Dirven¹, Pit J.S.M. Kerstens², Willem F. Lems³, Iris M. Markusse¹, Cornelia F Allaart¹ and Tom W.J. Huizinga¹, ¹Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ²Department of Rheumatology, Reade, Amsterdam, Netherlands, ³Department of Rheumatology, VU Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands
Background/Purpose: Joint damage in RA is thought to be irreparable. We hypothesized that in patients in whom inflammation is persistently well suppressed, repair may be…
Abstract Number: 436 • 2017 ACR/ARHP Annual Meeting
Baseline Anemia As a Predictor of Radiographic Progression in Tofacitinib-Treated Rheumatoid Arthritis Patients: Post Hoc Analyses from Two Phase 3 Trials
Burkhard Moeller¹, Axel Finckh², Godehard Scholz¹, Harry Shi³, Carol A Connell⁴ and Sander Strengholt⁵, ¹Department for Rheumatology, Immunology and Allergology, University Hospital of Bern, Bern, Switzerland, ²University Hospital of Geneva, Geneva, Switzerland, ³Pfizer Inc, Collegeville, PA, ⁴Pfizer Inc, Groton, CT, ⁵Pfizer Inc, Capelle aan den IJssel, Netherlands
Background/Purpose: Anemia in patients with rheumatoid arthritis (RA) can help to identify those with more rapid erosive disease.1,2 Tofacitinib is an oral Janus kinase inhibitor…
Abstract Number: 451 • 2017 ACR/ARHP Annual Meeting
A Matrix Risk Model for Prediction of Radiographic Progression in Early Rheumatoid Arthritis Based on Treatment Response at 3 Months
Pooneh S. Akhavan¹, Daming Li¹, Sahar Tabatabvakili¹ and Edward C. Keystone², ¹Mount Sinai Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada
Background/Purpose: The present study aimed to develop a matix to predict risk of radiographic progression in patients with early rheumatoid arthritis. The focus of this…
Abstract Number: 945 • 2016 ACR/ARHP Annual Meeting
When and Where Musculoskeletal Ultrasound Might Replace Magnetic Resonance in the Assessment of Patients with Juvenile Idiopathic Arthritis?
Stefano Lanni¹, Francesca Magnaguagno², Erica Ricci³, Angela Pistorio⁴, Cecilia Bava¹, Alberto Martini⁵ and Clara Malattia⁶, ¹Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, ³Istituto G. Gaslini, Pediatria 2 -Reumatologia, genova, Italy, ⁴Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ⁵PRINTO-IRCCS, Genova, Italy, ⁶Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Magnetic resonance imaging (MRI) is the most attractive imaging modality for the investigation of patients with juvenile arthritis (JIA). Musculoskeletal ultrasound (MSUS) has intuitive…
Abstract Number: 1111 • 2016 ACR/ARHP Annual Meeting
Huntingtin Interactin Protein 1 (HIP1) Regulates Receptor Tyrosine Kinases Mediated Activity and Cell Invasiness in Fibroblast-like Synoviocytes
Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Huntingtin-interacting protein 1 (Hip1) is a new arthritis severity gene recently identified in the Pristane and Collagen-induced arthritis (PIA, CIA) quantitative trait locus Cia25/Pia42…
Abstract Number: 1791 • 2016 ACR/ARHP Annual Meeting
Loss of Elbow Hyperextension in Females with Early Rheumatologic Disease Was Common in Systemic Lupus Erythematosus and Rheumatoid Arthritis but Rare in Fibromyalgia
John P. Case¹, Heidi Tucker² and Congbin Wang³, ¹Internal Medicine/Rheumatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, ²Rush Medical College, Chicago, IL, ³Internal medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL
Background/Purpose: The elbow extension angle (ELB) is commonly given as 180o although most healthy females exhibit hyperextension(1). The loss of hyperextension (LOH) in a…
Abstract Number: 2489 • 2016 ACR/ARHP Annual Meeting
Joint Damage Appears As Severe As Inflammation According to Physician Visual Analog Scales in Patients with Rheumatoid Arthritis Regardless of Disease Severity at 2 Sites, Which May Limit Results of a Treat-to-Target Strategy
Theodore Pincus¹, Isabel Castrejón¹, Kathryn Gibson² and Joel Block³, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Rheumatology, Liverpool Hospital and University of New South Wales, Liverpool, Australia, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of global status (DOCGL) on a 0-10 visual analog scale (VAS) was developed initially to assess inflammation in patients with rheumatoid…
Abstract Number: 3124 • 2016 ACR/ARHP Annual Meeting
Huntingtin Interacting Protein 1 (Hip1) Is a New Arthritis Severity Gene
Teresina Laragione¹, Percio Gulko¹ and Max Brenner², ¹Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ²Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Cia25/Pia42 is an arthritis severity and joint damage quantitative trait locus on rat chromosome 12 previously identified in an intercross between MHC identical but…
Abstract Number: 3157 • 2016 ACR/ARHP Annual Meeting
The Association Between Sonographic Enthesitis and Radiographic Damage in Psoriatic Arthritis
Ari Polachek¹, Dafna D Gladman², Richard J. Cook³, Vinod Chandran⁴ and Lihi Eder⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a common clinical finding and a key pathogenic feature in psoriatic arthritis (PsA). Ultrasound is emerging as a preferred method to assess…
Abstract Number: 1305 • 2015 ACR/ARHP Annual Meeting
Prevalence of MR-Detected Ramris-Defined Erosions in the General Population
L. Mangnus¹, H.W. van Steenbergen², M. Reijnierse³ and A.H.M. van der Helm- van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The diagnostic value of Magnetic Resonance (MR) imaging for Rheumatoid Arthritis (RA) is undetermined. The main value of MR is its sensitive depiction of…
Abstract Number: 1307 • 2015 ACR/ARHP Annual Meeting
Does Computerized Segmentation of Early Erosions on Magnetic Resonance Imaging Predict Functional Ability in Rheumatoid Arthritis?
Matthew Jessome¹, Michael Tomizza¹, Karen A. Beattie², William G. Bensen², Raja Bobba², Alfred Cividino², Patrick D. Emond², Chris Gordon², Lawrence Hart², George Ioannidis², Maggie Larche², Arthur Lau³, Ruben Tavares², Stephen Tytus² and Jonathan D. Adachi², ¹McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/Purpose: Functional ability of rheumatoid arthritis (RA) patients is reduced by both acute (inflammatory) and chronic (joint damage) disease manifestations. However, the impact of early…
Abstract Number: 1325 • 2015 ACR/ARHP Annual Meeting
Age Effects Joint Space Narrowing in Early Active Rheumatoid Arthritis Patients
Xanthe M.E. Matthijssen¹, Gülsah Akdemir¹, Iris M. Markusse², Yvonne P. Goekoop-Ruiterman³, K. Huub Han⁴, Annekoos L. Huidekoper⁵, Pit J.S.M. Kerstens⁶, Willem F. Lems⁷, T. W. J. Huizinga¹ and Cornelia F. Allaart¹, ¹Rheumatology, LUMC, Leiden, Netherlands, ²LUMC, Leiden, Netherlands, ³Rheumatology, HAGA hospital, The Hague, Netherlands, ⁴Rheumatology, Maasstad hospital, Rotterdam, Netherlands, ⁵Rheumatology, Bronovo hospital, The Hague, Netherlands, ⁶Department of Rheumatology, Reade, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands
Background/Purpose: Joint space narrowing (JSN) and erosions are the major radiologic markers of radiographic progression in rheumatoid arthritis (RA), as scored by the Sharp/van der…

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