ACR Meeting Abstracts

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Abstracts tagged "Janus kinase (JAK)"

  • Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis

    J. R. Curtis1, H. Schulze-Koops2, L Takiya3, C. A. Mebus4, K. Terry4, R. Chew4 and T. V. Jones3, 1Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Munich, Munich, Germany, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…
  • Abstract Number: 444 • 2013 ACR/ARHP Annual Meeting

    Reversibility Of Pharmacodynamic Effects After Short- and Long-Term Treatment With Tofacitinib In Patients With Rheumatoid Arthritis

    M. C. Genovese1, T. Kawabata2, K. Soma2, S. Menon2, J.D. Clark3, J. Hodge4, L. Takiya4, R. Riese2 and S. Krishnaswami5, 1Division of Rheumatology, Stanford University, Palo Alto, CA, 2Pfizer Inc, Groton, CT, 3Pfizer Inc, Cambridge, MA, 4Pfizer Inc, Collegeville, PA, 5Clinical Pharmacology, Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is a novel oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). It has a short pharmacokinetic (PK) half-life of…
  • Abstract Number: 2084 • 2012 ACR/ARHP Annual Meeting

    ASP015K: A Novel JAK Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis Model in Rats

    Shunji Yamazaki1, Masamichi Inami1, Misato Ito1, Yasutomo Fujii1, Kaori Hanaoka1, Kaoru Yamagami1, Kenji Okuma1, Yoshiaki Morita1, Shohei Shirakami2, Takayuki Inoue2, Susumu Miyata3 and Yasuyuki Higashi1, 1Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 2Chemistry Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 3Research Planning & Administration, Astellas Pharma Inc., Tsukuba, Japan

    Background/Purpose: The Janus kinase (JAK) family of enzymes plays a key role in cytokine signaling, which is involved in the pathogenic events of immune-mediated disorders…
  • Abstract Number: 1697 • 2012 ACR/ARHP Annual Meeting

    Meta-Analysis of Malignancies, Serious Infections, and Serious Adverse Events with Tofacitinib or Biologic Treatment in Rheumatoid Arthritis Clinical Trials

    Sima Ahadieh1, Tina Checchio1, Thomas Tensfeldt1, Jonathan French2, Sriram Krishnaswami1, Richard Riese3, Sujatha Menon1, Mary G. Boy1 and Jamie L. Geier4, 1Pfizer Inc., Groton, CT, 2Metrum Research Institute, Tariffville, CT, 3Pfizer Inc, Groton, CT, 4Epidemiology, Pfizer Inc., New York, NY

    Background/Purpose: Patients with rheumatoid arthritis (RA) experience adverse events (AEs) attributed to both the disease and its treatment. Tofacitinib is a novel oral Janus kinase…
  • Abstract Number: 1322 • 2012 ACR/ARHP Annual Meeting

    Coadministration of ASP015K, a Novel Janus Kinase Inhibitor with Methotrexate Demonstrates Tolerability and Lack of Pharmacokinetic Interactions in Patients with Rheumatoid Arthritis

    Tong Zhu1, Kazuo Oda2, Udaya Valluri1, Bogie Moore1, Ying Cao1, Vishala Chindalore3 and Bola Akinlade4, 1Astellas Pharma Global Development, Inc., Northbrook, IL, 2Drug Metabolism Research Labs. Drug Discovery Research, Astellas Pharma Inc., Osaka, Japan, 3Pinnacle Research Group/Anniston Medical Clinic, Anniston, AL, 4Immunology Development, Astellas Pharma Global Development, Inc., Northbrook, IL

    Background/Purpose: ASP015K is an oral Janus kinase (JAK) inhibitor with selectivity for JAK1/3 in development for treatment of rheumatoid arthritis (RA) and other autoimmune diseases.…
  • Abstract Number: 1297 • 2012 ACR/ARHP Annual Meeting

    Tofacitinib and Adalimumab Achieve Similar Rates of Low Disease Activity in Rheumatoid Arthritis — Lack of Improvement in Disease Activity Score by 3 Months Predicts Low Likelihood of Low Disease Activity At 1 Year

    Ronald F. van Vollenhoven1, Sriram Krishnaswami2, Birgitta Benda3, David Gruben4, Bethanie Wilkinson4, Charles A. Mebus4, Samuel H. Zwillich2 and John Bradley2, 1Karolinska Institute, Stockholm, Sweden, 2Pfizer Inc, Groton, CT, 3Pfizer Inc., Collegeville, PA, 4Pfizer Inc., Groton, CT

    Background/Purpose: Tofacitinib is a novel oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. This post-hoc analysis of the…
  • Abstract Number: 1277 • 2012 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in Combination with Methotrexate Reduced the Progression of Structural Damage in Patients with Rheumatoid Arthritis: Year 2 Efficacy and Safety Results From a 24-Month Phase 3 Study

    D. van der Heijde1, Y. Tanaka2, Roy Fleischmann3, Edward Keystone4, Joel M. Kremer5, C. Zerbini6, M. H. Cardiel7, S. B. Cohen8, P. T. Nash9, Y. Song10, D. Tegzova11, B. Wyman12, D. Gruben12, B. Benda13, G. Wallenstein14, S. Krishnaswami12, S. H. Zwillich12, J. Bradley15, C. A. Connell16 and ORAL Scan Investigators17, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2University of Occupational and Environmental Health, Kitakyushu, Japan, 3Metroplex Clinical Research Center, Dallas, TX, 4Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Toronto, ON, Canada, 5The Center for Rheumatology, Albany Medical College, Albany, NY, 6CEPIC – Centro Paulista de Investigação Clínica, São Paulo-SP, Sao Paulo, Brazil, 7Centro de Investigacion Clinica de Morelia, Morelia, Mexico, 8Metroplex Clinical Research Centre, Dallas, TX, 9Rheumatology Research Unit, Nambour Hospital, Sunshine Coast, Australia, 10Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 11Institute of Rheumatology, Prague, Czech Republic, 12Pfizer Inc., Groton, CT, 13Clinical Development & Medical Affairs, Pfizer Inc., Collegeville, PA, 14Pfizer Inc, New York, NY, 15Worldwide Pharmaceutical Development, Pfizer Inc., Groton, CT, 16Pfizer Inc, Groton, CT, 17Groton

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. This 24‑month (Mo) Phase 3…
  • Abstract Number: 1278 • 2012 ACR/ARHP Annual Meeting

    Tuberculosis and Tofacitinib Therapy in Patients with Rheumatoid Arthritis

    Kevin L. Winthrop1, S.-H. Park2, A. Gul3, M. Cardiel4, JJ Gomez-Reino5, D. Ponce de Leon6, R. Riese7, R. Chew7, T. Kawabata7, E. Mortensen6 and H. Valdez8, 1Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, 2The Catholic University of Korea, Seoul, South Korea, 3Istanbul University, Istanbul, Turkey, 4Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, 5Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 6Pfizer Inc., Collegeville, PA, 7Pfizer Inc., Groton, CT, 8Pfizer Inc., New York, NY

    Background/Purpose: Biologic therapies that block tumor necrosis factor-alpha (TNF) increase the risk of tuberculosis (TB), and screening for latent tuberculosis infection (LTBI) before their initiation…
  • Abstract Number: 1282 • 2012 ACR/ARHP Annual Meeting

    Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy up to 48 Months

    Jurgen Wollenhaupt1, Joel C. Silverfield2, Eun Bong Lee3, Susan P. Wood4, Koshika Soma5, Lisy Wang4, Hiroyuki Nakamura6, Yoshihiro Komuro6, Chudi I. Nduaka4, David Gruben4, Birgitta Benda7, Samuel H. Zwillich5, Richard Riese4 and John D. Bradley4, 1Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, 2Healthpoint Medical Group, Tampa, FL, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc., Groton, CT, 5Pfizer Inc, Groton, CT, 6Pfizer Japan Inc., Tokyo, Japan, 7Pfizer Inc., Collegeville, PA

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy in RA. Here we report the safety…
  • Abstract Number: 1283 • 2012 ACR/ARHP Annual Meeting

    Effects of Tofacitinib On Patient-Reported Outcomes in Patients with Active Rheumatoid Arthritis Receiving Stable-Dose Methotrexate: Results of Two Phase 3 Studies

    Gerd Burmester1, Désirée van der Heijde2, Vibeke Strand3, Cristiano A. F. Zerbini4, Carol A. Connell5, Charles A. Mebus5, Samuel H. Zwillich6, John D. Bradley5, David Gruben5 and Gene Wallenstein5, 1Department of Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Adjunct, Division of Immunology / Rheumatology, Stanford University, Palo Alto, CA, 4Centro Paulista de Investigação Clinica, Sao Paulo, Brazil, 5Pfizer Inc., Groton, CT, 6Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. The efficacy and safety of…
  • Abstract Number: 2546 • 2012 ACR/ARHP Annual Meeting

    Tofacitinib Inhibits Radiographic Progression in Patients with Rheumatoid Arthritis Prone to Develop Structural Damage: A Post-Hoc Analysis of a Phase 3 Trial

    Désirée van der Heijde1, Robert B. M. Landewé2 and David Gruben3, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, 3Pfizer Inc., Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. In the ORAL Scan trial…
  • Abstract Number: 1284 • 2012 ACR/ARHP Annual Meeting

    Evaluation of Influenza and Pneumococcal Vaccine Responses in Patients with Rheumatoid Arthritis Receiving Tofacitinib

    K. L. Winthrop1, A. Racewicz2, E. B. Lee3, B. Wilkinson4, S. H. Zwillich5, K. Soma4, S. Rottinghaus4, T. Kawabata4, R. Riese5, S. Wood5, J. Bradley6 and Clifton O. Bingham III7, 1Division of Infectious Diseases, Oregon Health and Science University, Portland, OR, 2Department of Internal Medicine and Osteoarthrology, Bialystok Regional Hospital, Bialystok, Poland, 3Seoul National University, Seoul, South Korea, 4Pfizer Inc, Groton, CT, 5Pfizer Inc., Groton, CT, 6Worldwide Pharmaceutical Development, Pfizer Inc., Groton, CT, 7Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. Clinical guidelines recommend the use…
  • Abstract Number: 2486 • 2012 ACR/ARHP Annual Meeting

    Radiographic, Clinical and Functional Comparison of Tofacitinib Monotherapy Versus Methotrexate in Methotrexate-Naïve Patients with Rheumatoid Arthritis

    Eun Bong Lee1, Roy Fleischmann2, Stephen Hall3, Ronald F. van Vollenhoven4, John Bradley5, David Gruben6, Tamas Koncz7, Sriram Krishnaswami5, Gene Wallenstein6, Samuel H. Zwillich5, Bethanie E. Wilkinson6 and the ORAL Start Investigators8, 1Seoul National University, Seoul, South Korea, 2Metroplex Clinical Research Center, Dallas, TX, 3Cabrini Medical Centre, Melbourne, Australia, 4Karolinska Institute, Stockholm, Sweden, 5Pfizer Inc, Groton, CT, 6Pfizer Inc., Groton, CT, 7Pfizer Inc., New York, NY, 8Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. This Phase 3, 24-mo study (ORAL…
  • Abstract Number: 1290 • 2012 ACR/ARHP Annual Meeting

    Effects of Tofacitinib On Lipid Profiles and Cholesterol and Lipoprotein Kinetics in Patients with Rheumatoid Arthritis

    Christina Charles-Schoeman1, Roy Fleischmann2, Jean Davignon3, Howard Schwartz4, Scott Turner5, Carine Beysen5, Mark Milad6, Zheng Luo7, John Bradley8, Irina Kaplan8, Richard Riese7, Andrea Zuckerman7 and Iain B. McInnes9, 1University of California, Los Angeles, CA, 2Metroplex Clinical Research Center, Dallas, TX, 3University of Montreal, Montreal, Canada, 4Miami Research Associates, Miami, FL, 5KineMed Inc., Emeryville, CA, 6Milad Pharmaceutical Consulting LLC, Plymouth, MI, 7Pfizer Inc., Groton, CT, 8Pfizer Inc, Groton, CT, 9Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Tofacitinib is a novel oral Janus kinase inhibitor being investigated as a targeted immunomodulator and disease-modifying therapy for RA. In RA patients (pts), suppression…
  • Abstract Number: 2488 • 2012 ACR/ARHP Annual Meeting

    Magnetic Resonance Imaging Substudy in a Phase 2b Dose-Ranging Study of Baricitinib, an Oral Janus Kinase 1/Janus Kinase 2 Inhibitor, in Combination with Traditional Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis

    Charles G. Peterfy1, Paul Emery2, Mark C. Genovese3, Edward Keystone4, Peter Taylor5, Pierre-Yves Berclaz6, Julie C. DiCarlo1, Chin H. Lee6, Douglas E. Schlichting6, Scott D. Beattie6, Monica E. Luchi7 and William Macias6, 1Spire Sciences LLC, Kentfield, CA, 2Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 3Division of Rheumatology, Stanford University, Palo Alto, CA, 4University of Toronto, Toronto, ON, Canada, 5NDORMS, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 6Eli Lilly and Company, Indianapolis, IN, 7E361/309, Incyte Corporation, Wilmington, DE

    Background/Purpose: Baricitinib (formerly, LY3009104/ INCB028050 ) is a novel, oral inhibitor of JAK1 and JAK2 in the JAK-STAT pathway. Primary results of this phase 2b…
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