Abstracts tagged "Janus kinase (JAK) and collagen"

Abstract Number: 2354 • 2014 ACR/ARHP Annual Meeting
Efficacy of a Novel Orally Bioavailable JAK1 Selective Compound in a Preclinical Rat Collagen-Induced Arthritis Model
Lily Y. Moy¹, Chi-Sung Chiu¹, Robert Faltus¹, Mark Zielstorff², Kalyan Chakravarthy¹, Sujal Deshmukh¹, Ilona Kariv¹, Joel Klappenbach¹, Jason Brubaker¹, Duan Liu¹, Tony Siu¹, Jonathan Young¹, Hongshi Yu¹, Fiona Elwood¹ and Milenko Cicmil¹, ¹Merck Research Laboratories, Boston, MA, ²Pharmacology, Merck Research Laboratories, Boston, MA
Background/Purpose Janus kinase (JAK) is a family of four tyrosine kinases that play a critical role in cytokine signaling and downstream lymphocyte activation and function. …

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Abstracts tagged "Janus kinase (JAK) and collagen"

Efficacy of a Novel Orally Bioavailable JAK1 Selective Compound in a Preclinical Rat Collagen-Induced Arthritis Model