Abstracts tagged "intravenous immunoglobulin (IVIG) and systemic lupus erythematosus (SLE)"

Abstract Number: 1791 • ACR/ARHP Annual Meeting 2012
Different Mechanisms Responsible for IVIG Inhibition of Immune Complex Versus TLR Stimulated Interferon-Alpha
Alice Wiedeman¹, Fabian Käsermann², Sylvia Miescher² and Keith B. Elkon³, ¹Department of Immunology, University of Washington, Seattle, WA, ²CSL Behring, Bern, Switzerland, ³Rheumatology Box 356428, University of Washington, Seattle, WA
Background/Purpose: SLE immune complexes (IC) induce IFN-α production by stimulation of TLR7 and 9 in plasmacytoid dendritic cells (pDC). Serum from normal human donors…