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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting

    Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration

    Richard Bell1, Emily Wu1,2, Homaira Rahimi3 and Edward Schwarz1,4,5, 1Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 2Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 3Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, 4University of Rochester, Rochester, NY, 5Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY

    Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
  • Abstract Number: 1684 • 2017 ACR/ARHP Annual Meeting

    Effectiveness and Safety of Tacrolimus Following Intravenous Cyclophosphamide Pulse Therapy As the Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease

    Yuki Ichimura, Yasushi Kawaguchi, Kae Takagi, Akiko Tochimoto, Tomoaki Higuchi, Yasuhiro Katsumata and Hisashi Yamanaka, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is the disease characterized by organ fibrosis with unknown etiology, and pulmonary involvement is one of major cause of death. However,…
  • Abstract Number: 1695 • 2017 ACR/ARHP Annual Meeting

    Baseline Characteristics and Outcomes in a Retrospective Cohort of Patients with Systemic Sclerosis Related Interstitial Lung Disease

    Robert L. Mango1, Eric L. Matteson2, Cynthia S. Crowson3, Jay H. Ryu4 and Ashima Makol2, 1Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, MN, 2Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN

    Background/Purpose: Interstitial lung disease (ILD) is a major contributor to morbidity and mortality in systemic sclerosis (SSc). We sought to identify the distribution of clinical…
  • Abstract Number: 1702 • 2017 ACR/ARHP Annual Meeting

    Disease Progression in Systemic Sclerosis Patients with Concomittant or Isolated Interstitial Lung Disease and Pulmonary Arterial Hypertension in the Scleroderma Cohort Singapore

    Maria Noviani1, Seyed Ehsan Saffari2, Sandra Mei Yu Kua1, Grace Yin Lai Chan3, Gim Gee Teng4, Weng Giap Law5, Amelia Santosa4, Anita Yee Nah Lim4, Swee Cheng Ng1 and Andrea Hsiu Ling Low1, 1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, Singapore, 2Center for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore, Singapore, 3Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, SIngapore, Singapore, 4Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, Singapore, Singapore, 5Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore, Singapore

    Background/Purpose: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of mortality in patients with systemic sclerosis (SSc).  We aimed to determine…
  • Abstract Number: 2008 • 2017 ACR/ARHP Annual Meeting

    “Intrathoracic Manifestations of Connective Tissue Diseases on High Resolution Computed Tomography”

    Diego Baenas1, Maira Orozco2, María Eugenia Olmos3, Luis Lasca4, Paula Riba5, Patricio Muszinsky5, Juan Pablo Pirola6, Verónica Saurit7, Alejandro Alvarellos7, Ana C. Alvarez8, Soledad Retamozo9,10, Nadia Riscanevo7,11, Janet Flores12, Ariel Blua3, Ana María López13, Gustavo Muiño14, Santiago Orozco15 and Francisco Caeiro16, 1Rheumatology Unit, Hospital Privado Universitario de Córdoba, Postgraduate Career of Rheumatology Catholic University of Córdoba., Cordoba, Argentina, 2Radiology, Radiology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 3Pulmonary, Pulmonary Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 4Radiology Unit, Oulton Institute, Cordoba, Argentina, 5Radiology, Radiology Unit, Oulton Institute, Cordoba, Argentina, 6Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 7Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 8Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, 9Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, 10Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 11Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 12Rheumatology Unit, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, 13Pulmonary Unit, Pulmonary Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 14Radiology, Radiology Unit,Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 15Radiology, Radiology Unit, Hospital Privado Universitario de Córdoba., Cordoba, Argentina, 16Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina

    Background/Purpose: Connective tissue diseases (CTD) can cause intrathoracic involvement, increasing patients morbidity and mortality. High-resolution computed tomography (HRCT) is a key method for evaluation of…
  • Abstract Number: 2114 • 2017 ACR/ARHP Annual Meeting

    Interstitial Pneumonia with Autoimmune Features (IPAF): Are There Definable Subsets?

    Sepehr Mesdaghinia1, Julio Arturo Huapaya2, Brainerd Ewarien2 and Virginia D. Steen1, 1Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 2Medicine, MedStar Georgetown University Hospital, Washington, DC

    -       Background/Purpose: Interstitial lung disease (ILD) can be an early manifestation of an occult connective tissue disease (CTD).  It is important to separate these patients…
  • Abstract Number: 2150 • 2017 ACR/ARHP Annual Meeting

    Serum Microrna-1 Can be a Predictive Marker for Disease Activity of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease

    Yumiko Sugiyama, Ryusuke Yoshimi, Yosuke Kunishita, Daiga Kishimoto, Yohei Kirino and Hideaki Nakajima, Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Although intensive immunosuppressive treatment are necessary for the severe cases with polymyositis (PM)/dermatomyositis (DM), the prognostic factors or disease activity indices for PM/DM have…
  • Abstract Number: 2151 • 2017 ACR/ARHP Annual Meeting

    The Predictive Risk Factors for Opportunistic Infection during Treatment for Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease

    Yumiko Sugiyama1,2, Ryusuke Yoshimi1,2, Maasa Tamura2,3, Naoki Hamada1,2, Hideto Nagai1,2, Naomi Tsuchida1,4, Yosuke Kunishita1,2, Yutaro Soejima1,2, Daiga Kishimoto1,2, Reikou Kamiyama1,2, Kaoru Minegishi1,5, Yohei Kirino1,2, Shigeru Ohno1,6 and Hideaki Nakajima2, 1Y-CURD Study Group, Yokohama, Japan, 2Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 3Y-CURD Study Group, Yokohma, Japan, 4Department of Hematology and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 5Rheumatic Disease Center, Yokohama City University Medical Center, Yokohama, Japan, 6Center for Rheumatic Disease, Yokohama City University Medical Center, Yokohama, Japan

    Background/Purpose: Although concomitant infectious diseases are the predominant causes of death in patients with polymyositis (PM)/dermatomyositis (DM)-associated interstitial lung disease (ILD), intensive immunosuppressive treatment are…
  • Abstract Number: 2160 • 2017 ACR/ARHP Annual Meeting

    Clinical Significance of Anti-Aminoacyl tRNA Synthetase Antibodies Which Are Positive By ELISA but Not By Immunoprecipitation – the Variations of Antigen Recognition and the Association with Interstitial Lung Diseases but Not Myositis –

    Yuki Ishikawa1,2, Ran Nakashima1, Takaki Nojima3,4, Takuya Isayama5, Nobuo Kuramoto1, Kosaku Murakami1, Hajime Yoshifuji1, Koichiro Ohmura1 and Tsuneyo Mimori1, 1Clinical Immunology and Rheumatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2One Joslin Place, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 3Clinical Immunology and Rheumatolog, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Nojima Internal Medicine Clinic, Hiroshima, Japan, 5Medical & Biological Laboratories CO.,LTD., Nagoya, Japan

    Background/Purpose: Anti-aminoacyl tRNA synthetase (ARS) antibodies are associated with common clinical characters, which are fever, polyarthritis, interstitial lung disease (ILD), Raynaud’s phenomenon, mechanic’s hand and…
  • Abstract Number: 2173 • 2017 ACR/ARHP Annual Meeting

    Characteristics Unique to MDA5 and Anti-Ro/SSA-52 Kda Dual Antibody Positive Patients with Inflammatory Myopathies

    Juan J Maya, Olga Pinkston, Florentina Berianu, Benjamin Wang and Andy Abril, Rheumatology, Mayo Clinic Florida, Jacksonville, FL

    Background/Purpose: The anti-melanoma differentiation-associated gene 5 antibody (MDA5) was recently classified as a myositis-specific antibody (MSA), and has been associated with rapidly progressive interstitial lung…
  • Abstract Number: 98 • 2017 ACR/ARHP Annual Meeting

    Impact of a Lung Ultrasound Course for Rheumatology Specialist (IMPACT-2)

    Christopher Gasho1, Karina Torralba2, David Chooljian3, Cong-Bin Wang4 and Vi Dinh4, 1Pulmonary and Critical Care Medicine, Loma Linda Medical Center, 12354 Anderson St, CA, 2Division of Rheumatology, Department of Internal Medicine, Loma Linda University, Loma Linda, CA, 3Loma Linda Veteran Affairs Hospital, Loma Linda, CA, 4Loma Linda University Medical Center, Loma Linda, CA

                Background/Purpose: Although much emphasis is focused on lung ultrasonography(US) within the critical care field, there is a growing interest in the use of lung…
  • Abstract Number: 2392 • 2017 ACR/ARHP Annual Meeting

    Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

    Namrata Singh1, Jimmy Varghese2, Bryant R. England3, Joshua J. Solomon4, Kaleb Michaud5, Ted R. Mikuls6 and Marin Schweizer7, 1Internal Medicine, University of Iowa Hospitals and Clinics and Iowa City VA, Iowa City, IA, 2Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, 3Division of Rheumatology & Immunology, Department of Internal Medicine, Nebraska-Western IA VA Health Care System & University of Nebraska Medical Center, Omaha, NE, 4Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 5University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Internal Medicine, Iowa City VA, Iowa City, IA

    ABSTRACT Impact of the Pattern of Interstitial Lung Disease on Mortality in Rheumatoid Arthritis: A systematic review and meta-analysis Background/Purpose: Interstitial lung disease affects 10-15%…
  • Abstract Number: 257 • 2017 ACR/ARHP Annual Meeting

    The Use of Positron Emission Tomography (PET)-Scan for the Quantitative Assessment of Interstitial Lung Disease in Systemic Sclerosis

    Daphne Peelen1, Ben Zwezerijnen2, Esther Nossent1, Lilian Meijboom1, Otto Hoekstra3, Conny van der Laken4 and Alexandre Voskuyl4, 1VUmc, Amsterdam, Netherlands, 2Nuclear Medicine, VUmc, Amsterdam, Netherlands, 3Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 4Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) in systemic sclerosis is treated by immunosuppressive drugs (e.g. cyclophosphamide), aimed at reduction of inflammatory response . Differentiation between inflamed…
  • Abstract Number: 2402 • 2017 ACR/ARHP Annual Meeting

    Rituximab in Rheumatoid Arthritis with Interstitial Lung Disease: A Multicenter Study of 32 Patients

    Carlos Fernández-Díaz1, Delia Reina2, Paula Rubio-Muñoz3, Ana Urruticoechea-Arana4, María Carrasco-cubero5, María Martín-López6, Jose A. Miranda-Filloy7, Ignacio Villa-Blanco8, Ana Milena Millan9, Ivan Castellví10, Olga Maiz-Alonso11, Antonio Juan12, Fátima Álvarez Reyes13, José Luis Martín-Varillas1, Nuria Vegas-Revenga1, Ricardo Blanco1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 3Rheumatology,, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, 4Rheumatology Department. Hospital Can Misses, IBIZA, Spain, 5Hospital Infanta Cristina, Badajoz, Spain, 6Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 7Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 8Hospital de Sierrallana, Sierrallana, Spain, 9Unitat de Reumatologia. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Hospital Universitario Donostia. San Sebastian. Spain, Donostia, Spain, 12Hospital Universitario Son Llàtzer. Rheumatology, Palma de Mallorca, Spain, 13Rheumatology, University Hospital Ntra. Sra. de La Candelaria, Santa Cruz de Tenerife, Spain

    Background/Purpose: Anti-TNFα drugs and several conventional disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate (MTX) have been involved in the development of Interstitial Lung Disease (ILD).…
  • Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting

    Mast Cells Are Involved in the Pathogenesis of Sjögren  Syndrome By Inducing Tissue Fibrosis

    Shinjiro Kaieda1, Kyoko Fujimoto2, Masaki Okamoto3, Masaki Tominaga2, Tomoaki Hoshino4 and Hiroaki Ida5, 1Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, 2Kurume University School of Medicine, Kurume, Japan, 3Medicine, Kurume University School of Medicine, Kurume, Japan, 4Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, 5Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…
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