ACR Meeting Abstracts

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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 0290 • ACR Convergence 2021

    Prevalence and Predictors of Mortality in Rheumatoid Arthritis-Related Lung Disease: Results from a Single Center Study

    Didem Sahin Eroglu1, Anil Colaklar2, Serdar Baysal3, Murat Torgutalp1, Asaf Baygul4, Serdar Sezer1, Emine Aydemir Guloksuz1, Mehmet Yuksel1, Mucteba Yayla1, Emine Uslu yurteri5, Caglar Uzun2, Ozlem Ozdemir kumbasar4, Murat Turgay1, Kinikli Gulay1 and Askin Ates1, 1Ankara University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 2Ankara University Faculty of Medicine, Department of Radiology, Ankara, Turkey, 3Ankara University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 4Ankara University Faculty of Medicine, Department of Pulmonology, Ankara, Turkey, 5Hatay Training and Research Hospital, Hatay, Turkey

    Background/Purpose: Rheumatoid arthritis-related lung disease (RA-LD) is a common manifestation of rheumatoid arthritis (RA) and associated with excess mortality. Many studies to date were focused…
  • Abstract Number: 0561 • ACR Convergence 2021

    Enhancing the Identification of Rheumatoid Arthritis-Associated Interstitial Lung Disease in Electronic Health Records Through Text Mining of Computerized Tomography Reports

    Brent Luedders1, Brendan Cope2, Matt Devries2, W. Scott Campbell2, James Campbell2, Ted Mikuls3, Jeffrey Curtis4, Daniel Hershberger3 and Bryant England3, 1University of Nebraska Medical Center, Omaha, NE, United Kingdom, 2University of Nebraska Medical Center, Omaha, 3University of Nebraska Medical Center, Omaha, NE, 4Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Interstitial lung disease (ILD) is an extraarticular manifestation of RA that leads to increased morbidity and mortality. Algorithms incorporating multiple diagnostic and procedure codes…
  • Abstract Number: 1372 • ACR Convergence 2021

    Outcomes and Risk Factors for Respiratory Failure in Patients with Scleroderma Associated with ILD

    Soumyasri Kambhatla1, Augustine Manadan2 and Amy Trang2, 1Rush University, Chicago, IL, 2Rush University Medical Center, Chicago, IL

    Background/Purpose: Scleroderma is associated with underlying ILD. About 48% those with diffuse cutaneous SSc and 26% of those with limited cutaneous SSc were found to…
  • Abstract Number: 1846 • ACR Convergence 2021

    Effect of Nintedanib in Patients with Systemic Sclerosis-associated Interstitial Lung Disease and Risk Factors for Rapid Decline in Forced Vital Capacity: Further Analyses of the SENSCIS Trial

    Dinesh Khanna1, Toby M Maher2, Elizabeth Volkmann3, Yannick Allanore4, Vanessa Smith5, Shervin Assassi6, Michael Kreuter7, Anna-Maria Hoffmann-Vold8, Masataka Kuwana9, Christian Stock10, Margarida Alves11, Steven Sambevski11 and Christopher Denton12, 1University of Michigan, Ann Arbor, MI, 2National Heart and Lung Institute, Imperial College London, UK, National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK, and Keck School of Medicine, University of Southern California, Los Angeles, CA, 3Department of Medicine, Division of Rheumatology, University of California, David Geffen School of Medicine, Los Angeles, CA, 4Department of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, 5Department of Rheumatology and Internal Medicine, Ghent University Hospital, Ghent, Belgium, 6University of Texas McGovern Medical School at Houston, Houston, TX, 7Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Care Medicine, Thoraxklinik, University of Heidelberg, Member of the German Center for Lung Research, Heidelberg, Germany, 8Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 9Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 10Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, 11Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim, Germany, 12University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom

    Background/Purpose: In the SENSCIS trial conducted in a population of subjects with systemic sclerosis-associated interstitial lung disease (SSc-ILD), with a mean time since onset of…
  • Abstract Number: 0291 • ACR Convergence 2021

    IgA Anti-Cyclic Citrullinated Peptide Antibodies in Bronchoalveolar Lavage Fluid from Patients with Idiopathic Pulmonary Fibrosis Are Associated with Reduced Mortality

    Scott Matson1, Candace Cephers2, Timothy Wilson3, Valerie Minarchick3, Kevin Brown4, Joshua Solomon4 and Kristen Demoruelle5, 1University of Kansas, Kansas City, MO, 2St Joseph Hospital, Internal Medicine, Denver, CO, 3University of Colorado, Denver, CO, 4National Jewish Health, Denver, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Idiopathic pulmonary fibrosis (IPF) is a form of interstitial lung disease (ILD) that shares many clinical features with rheumatoid arthritis (RA) associated ILD. Our…
  • Abstract Number: 0566 • ACR Convergence 2021

    Natural Language Processing of Electronic Health Record Notes Captures Forced Vital Capacity in Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Punyasha Roul1, Yangyuna Yang1, Daniel Hershberger1, Ted Mikuls1, Jorge Rojas2, Jeffrey Curtis3, Joshua Baker4, Brian Sauer5 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2VA Puget Sound, Seattle, WA, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4University of Pennsylvania, Philadelphia, PA, 5University of Utah, Salt Lake City, UT

    Background/Purpose: Rheumatoid arthritis-interstitial lung disease (RA-ILD) has a poor long-term prognosis, including premature mortality. Longitudinal monitoring of patients in clinical and clinical trial settings includes…
  • Abstract Number: 1379 • ACR Convergence 2021

    Serum Levels of the Soluble Receptor for Advanced Glycation Endproducts Are Prospectively Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis

    Isabella Atzeni1, Yehya Al-Adwi2, Berber Doornbos-van der Meer2, Anniek Van Roon2, Caroline Roozendaal1, Andries Smit2, Alja J. Stel2, Harry Van Goor2, Tji-Joong Gan1, Johanna Westra2 and Douwe J Mulder2, 1University of Groningen, University Medical Centre Groningen, Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are the leading causes of death in Systemic Sclerosis (SSc). Markers for early detection of…
  • Abstract Number: 1847 • ACR Convergence 2021

    Severity of Gastroesophageal Reflux, but Not the Use of Proton Pump Inhibitors, Is Associated with Radiographic Progression of Interstitial Lung Disease in Systemic Sclerosis

    Elizabeth Volkmann1, Donald Tashkin2, Mei Leng2, Grace Kim2, Jonathan Goldin2 and Michael Roth2, 1Department of Medicine, Division of Rheumatology, University of California, David Geffen School of Medicine, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Esophageal dysmotility is a common feature of systemic sclerosis (SSc) and aspiration of gastric contents may serve as an inciting and/or exacerbating factor in…
  • Abstract Number: 0294 • ACR Convergence 2021

    Comparison of Factors Associated with CT-Scan Progression of Interstitial Lung Disease in Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis. Retrospective Multicenter Study of 144 Patients

    Charlotte Lucas1, Aurore Tremblay1, Thibaut Lapotre2, Stéphane Jouneau3, Mathieu Lederlin2 and Aleth Perdriger1, 1Rheumatology department, University Hospital, Rennes, France, 2Radiology Department, University Hospital, Rennes, France, 3Department of Respiratory Medicine, Competences Centre for Rare Pulmonary Diseases, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France, Rennes, France

    Background/Purpose: Compare factors associated with interstitial lung disease (ILD) progression determined on CT-scan analysis and survival in two distinct populations, patients with rheumatoid arthritis associated…
  • Abstract Number: 0574 • ACR Convergence 2021

    Prevalence and Early Progression of Lung Diseases in Patients with Recently-Diagnosed Rheumatoid Arthritis: A Prospective Cohort Study

    Tina Mahajan1, Daniel Hershberger1, Matt Devries2, Punyasha Roul1, Yangyuna Yang1, Sherrie Edwards1, Geoffrey Thiele1, Ted Mikuls1, James O'Dell1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha

    Background/Purpose: Several types of lung diseases complicate the rheumatoid arthritis (RA) disease course such as interstitial lung disease (ILD) and obstructive lung diseases. The prevalence…
  • Abstract Number: 1381 • ACR Convergence 2021

    Chemokines CCL2 and CCL17 as Potential Serum Biomarkers for Interstitial Lung Disease in Systemic Sclerosis

    Imon Barua1, Håvard Fretheim2, Hilde Jenssen Bjørkekjær3, Henriette Didriksen4, Oyvind Midtvedt2, Trond Mogens AAløkken2, Torhild Garen5, Oyvind Molberg6, John Belperio7 and Anna-Maria Hoffmann-Vold1, 1Department of Rheumatology, Oslo University Hospital, Oslo, Norway, 2Oslo University Hospital, Oslo, Norway, 3Department of Rheumatology, Sørlandet sykehus HF, Kristiansand, Norway, 4Oslo University Hospital, Moss, Norway, 5Department of Rheumatology, Oslo University Hospital, Oslo, Nepal, 6Oslo University Hospital, Oslo, Nepal, 7University of California Los Angeles Interstitial Lung Disease Center, Los Angeles, CA

    Background/Purpose: Systemic sclerosis (SSc) carries high risk for progressive interstitial lung disease (ILD). Several anti-inflammatory therapies have been used to treat SSc-ILD and recently the…
  • Abstract Number: 1850 • ACR Convergence 2021

    Continued Treatment with Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD): Two-Year Data from SENSCIS-ON

    Yannick Allanore1, Madelon C Vonk2, Oliver Distler3, Arata Azuma4, Maureen Mayes5, Martina Gahlemann6, Alexandra James7, Veronika Kohlbrenner8, Margarida Alves9, Dinesh Khanna10 and Kristin B Highland11, 1Department of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, 2Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland, 4Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, 5Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 6Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, 7Elderbrook solutions GmbH, Bietigheim-Bissingen, Germany, Bietigheim-Bissingen, Germany, 8Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, 9Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim, Germany, 10University of Michigan, Ann Arbor, MI, 11Cleveland Clinic, Cleveland, OH

    Background/Purpose: In the SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks by…
  • Abstract Number: 0279 • ACR Convergence 2020

    Pulmonary Involvement in a Single Center Cohort of Patients with Systemic Lupus Erythematosus

    Naci Senkal1, Esen Kiyan2, Elif Kocasoy-Orhan3, Ali Demir4, Mehmet Aydogan5, Yasemin Yalcinkaya6, Ahmet Gul6, Murat Inanc7, Mahdume Lale Öcal6 and Bahar Artım-Esen6, 1Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey, 2Department of Chest Disease, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey, 3Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey, 4Fulya Radiologic Imaging Center, İstanbul, Turkey, 5Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey, 6Department of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey, 7Department of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Background/Purpose: The prevalence of SLE pulmonary involvement varies depending on several factors, including diagnostic methods. In this study, we sought to determine the frequency of…
  • Abstract Number: 1049 • ACR Convergence 2020

    Effects of Nintedanib in Patients with Progressive Fibrosing Autoimmune Disease-related Interstitial Lung Diseases (ILDs) in the INBUILD Trial: Subgroups by HRCT Pattern

    Paul Dellaripa1, Martin Aringer2, Anna Maria Hoffmann-Vold3, Clive Kelly4, Shikha Mittoo5, Alexandra James6, Klaus Rohr6, Susanne Stowasser6 and Yoshikazu Inoue7, 1Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA, Boston, MA, 2Rheumatology, Medicine III, University Medical Center & Faculty of Medicine, TU Dresden, Dresden, Germany, Dresden, Germany, 3Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 4Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, Newcastle upon Tyne, United Kingdom, 5University Health Network, Toronto, Ontario, Canada, Toronto, ON, Canada, 6Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 7Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan, Sakai City, Osaka, Japan

    Background/Purpose: In the INBUILD trial, nintedanib reduced the rate of decline in forced vital capacity (FVC) over 52 weeks compared with placebo in patients with…
  • Abstract Number: 1194 • ACR Convergence 2020

    MUC5B Promoter Variant rs35705950 and Risk Stratification for Rheumatoid Arthritis – Interstitial Lung Disease

    Pierre-Antoine Juge1, Fabienne Louis-Sidney2, Benjamin Granger3, Joanna Kedra4, Marie-Pierre Debray5, Esther Ebstein1, Raphaël Borie6, Arnaud Constantin7, Bernard Combe8, Rene-Marc Flipo9, Xavier Mariette10, Olivier Vittecoq11, Alain Saraux12, Guillermo Carvajal Alegria13, Jean Sibilia14, Francis Berenbaum15, Caroline Kannengiesser16, Bruno Crestani6, Catherine Boileau16, Bruno Fautrel17 and Philippe Dieude18, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2Service de Rhumatologie, CHU de Fort de France, Martinique, France, Fort de France, France, 3Département de Biostatistiques, Santé Publique et Information Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France., Paris, France, 4Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, UMR S1136, Paris, France, Paris, France, 5Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 6Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 7Hospital Pierre Paul Riquet, Toulouse, France, 8University of Montpellier, Montpellier, France, 9Lille University Hospital, Lille, France, 10Paris-Sud University, Rueil-Malmaison, France, 11University Hospital of Rouen, Rouen, France, 12Department of Rheumatology, UBO, CHU, INSERM 1227 (LBAI), Brest, France, 13CHU de Brest, Service de Rhumatologie, Brest, France, 14CHU Strasbourg, Service de Rhumatologie, Strasbourg, France, 15AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 16Université de Paris, Hôpital Bichat, Service de Génétique, AP-HP, Paris, Paris, France, 17Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, 18Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) detected in 20 to 60% of patients with RA on high-resolution computed-tomography…
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