ACR Meeting Abstracts

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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 708 • 2019 ACR/ARP Annual Meeting

    Improvement and Stabilization of Lung Function in Patients with SSc-ILD Treated with Nintedanib vs Placebo in a Randomized, Placebo-Controlled Phase III Trial: Proportions of Patients with FVC Changes Using Cutoffs Previously Proposed to Define Minimally Clinically Important Differences

    Yannick Allanore1, Dinesh Khanna 2, Elizabeth Volkmann 3, Christian Stock 4, Martina Gahlemann 5, Nils Schoof 6, Oliver Distler 7 and Toby Maher 8, 1Dept. of Rheumatology A, Descartes University, APHP, Cochin Hospital, Paris, France, Paris, France, 2Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 4Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 5Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, 6Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, 7Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 8National Heart and Lung Institute, Imperial College London, UK and National Institute for Health Research Clinical Research Facility, Royal Brompton Hospital, London, UK, London, United Kingdom

    Background/Purpose: Mean change in forced vital capacity percent predicted (FVC %pred) is a common endpoint in the assessment of treatment-related outcomes in patients with interstitial…
  • Abstract Number: 1649 • 2019 ACR/ARP Annual Meeting

    Mycophenolate Mofetil and Cyclophosphamide Improve Health-Related Quality of Life in Patients with Systemic Sclerosis Who Participated in SLS II

    Elizabeth Volkmann1, Donald Tashkin 2, Michael Roth 3, Holly LeClair 2, Philip Clements 2, Daniel Furst 4, Robert Elashoff 2 and Dinesh Khanna 5, 1University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 2University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 4University of California, Los Angeles, CA, 5Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor

    Background/Purpose: Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc). The majority of studies investigating novel therapies for…
  • Abstract Number: 2344 • 2019 ACR/ARP Annual Meeting

    Efficacy of Mycophenolate Mofetil in the Treatment of Rheumatoid Arthritis Associated Interstitial Lung Disease

    Jonathan Amos1, Jennifer Kendall 1, Robyn Moran 2, Megan Krause 3, Paul Schmidt 4, Chase Hall 5, Mark Hamblin 6 and Mehrdad Maz 7, 1University of Kansas Medical Center, Division of Rheumatology, KANSAS CITY, KS, 2University of Kansas Medical Center, Kansas City, KS, 3University of Kansas, KANSAS CITY, KS, 4University of Kansas Medical Center, Division of Rheumatology, Kansas City, 5University of Kansas Medical Center, Division of Pulmonary and Critical Care, KANSAS CITY, 6University of Kansas Medical Center, Division of Pulmonary and Critical Care, Kansas City, KS, 7The University of Kansas Medical Center, KANSAS CITY, KS

    Background/Purpose: Interstitial lung disease (ILD) as an extra-articular manifestation of rheumatoid arthritis (RA) leads to significant morbidity and mortality.  As data is limited, this study…
  • Abstract Number: 712 • 2019 ACR/ARP Annual Meeting

    Safety and Tolerability of Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the SENSCIS Trial: Subgroup Analysis Based on Demographic Characteristics

    Oliver Distler1, Kristin Highland 2, Maureen Mayes 3, Masataka Kuwana 4, Lesley Saketkoo 5, Madelon Vonk 6, Michael Kreuter 7, Laura Hummers 8, Ute von Wangenheim 9, Martina Gahlemann 10, Veronika Kohlbrenner 11, Margarida Alves 12, Emmanuelle Clerisme-Beaty 12 and Arata Azuma 13, 1Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 2Cleveland Clinic, Cleveland, Ohio, USA, Cleveland, OH, 3Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, 5New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans; Tulane University School of Medicine, University Medical Center – Comprehensive Pulmonary Hypertension Center, USA, New Orleans, 6Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands, Nijmegen, Gelderland, Netherlands, 7Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Member of the German Center for Lung Research, Germany, Germany, Germany, 8Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, USA, Baltimore, MD, 9Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, Biberach an der Riss, 10Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland, Basel, Switzerland, 11Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA, Ridgefield, 12Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 13Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan, Tokyo, Japan

    Background/Purpose: In the SENSCIS trial in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD), the adverse events associated with nintedanib were manageable for most patients…
  • Abstract Number: 1654 • 2019 ACR/ARP Annual Meeting

    Esophageal Dilation and Other Clinical Factors Associated with Pulmonary Function Decline in Patients with Systemic Sclerosis

    Kimberly Showalter1, Aileen Hoffmann 2, Carrie Richardson 3, Kimberly Koloms 2, Gerald Rouleau 2, David Aaby 2, Julia (Jungwha) Lee 4, Jane Dematte 2, Rishi Agrawal 2, Xiaoping Wu 5, Rowland Chang 4 and Monique Hinchcliff 6, 1Hospital for Special Surgery, New York, NY, 2Northwestern University Feinberg School of Medicine, Chicago, 3Rush University, Chicago, 4Northwestern University Feinberg School of Medicine, Chicago, IL, 5New York Presbyterian/Weill Cornell, New York, 6Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT

    Background/Purpose: Prior work has shown that Scl-70 positive autoantibody status and baseline c-reactive protein (CRP) are associated with more rapid pulmonary function decline in patients…
  • Abstract Number: 2345 • 2019 ACR/ARP Annual Meeting

    Abatacept in Rheumatoid Arthritis with Interstitial Lung Disease: A Retrospective Multicenter Study of 263 Patients

    C. Fernández-Díaz1, Rafael Melero 2, Javier Loricera 3, Santos Castañeda 4, Francisco Ortiz-Sanjuán 5, I. Casafont-Solé 6, Carmen carrasco-Cubero 7, A. Juan-Mas 8, Raquel Almodovar-Gonzalez 9, S. Rodriguez-Garcia 10, R. Castellanos 11, O. Maiz-Alonso 12, C. Aguilera-Cros 13, I. Cabezas-rodriguéz 14, EC Cervantes 15, M. Moreno 16, L. Arboleya 17, C. Montagut 18, Patricia Carreira 19, C. Ojeda-Garcia 20, Gema Bonilla 21, T. Perez-Sandoval 22, P. Vela 23, JL Andreu 24, Susana Romero-Yuste 25, A. Urruticoechea-Arana 26, E. Salgado-Pérez 27, Cristina Hidalgo 28, Javier Narváez 29, E. Raya 30, MJ. Moreno-Ramos 31, P. Morales-Garrido 32, L. Pérez-alba 33, Carlos Fernández-López 34, Ignacio Villa 35, Noelia Álvarez-Rivas 36, Juan María Blanco-Madrigal 37, JR Jimenez-Aberasturi 38, A. Perez-Linaza 39, N. Del-val-del-amo 40, Sabela Fernández 41, A. García-valle 42, C.A. Peralta-Ginés 43, A. Garcia-Aparicio 44, L. Exposito-pérez 45, N. Mena-Vazquez 46, R. López-Sánchez 47, B. Garcia-magallon 48, Miguel Angel González-Gay 49 and Ricardo Blanco 50, 1HU Vinalopo, Madrid, Madrid, Spain, 2Complexo Hospitalario Universitario de Vigo, Vigo, Galicia, Spain, 3Rheumatology Department. Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, 4Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, 5Hospital Universitario y Politécnico La Fe, Valencia, Comunidad Valenciana, Spain, 6HU German Trias i pujol, BAacelona, 7CHU de Badajoz, Badajoz, Spain, 8H Son Llázer, Palma de Mallorca, Islas Baleares, Spain, 9Hospital Universitario Fundación Alcorcón, Madrid, Spain, 10HU. Clinic, Barcelona, 11Fundacio Clinic. Hospital Clinic de Barcelona, Barcelona, Spain, 12HU Donostia, Donostia, Spain, 13hospital virgen del rocio, Sevilla, Spain, 14HU. Río Hortega, Valladolid, Spain, 15HU Santiago de compostela, Santiago, 16Parc Tauli Hospital Universitari, Sabadell, Spain, 17Hospital Central Asturias, OViedo, 18HCU Valladolid, Valladolid, Spain, 19Hospital Universitario 12 de Octubre, Madrid, Spain, 20HU Virgen de la Macarena, Sevilla, 21Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, Madrid, Spain, 22HU León, León, Spain, 23Hospital General Universitario de Alicante, Alicante, Comunidad Valenciana, Spain, 24HU Puerta del Hierro, Madrid, 25Complejo Hospitalario Universitario Pontevedra, Pontevedra, Galicia, Spain, 26HU Can Misses, Ibiza, Spain, 27C.H Ourense, Ourense, 28Hospital Clínico Universitario de Salamanca, Salamanca, Castilla y Leon, Spain, 29Rheumatology Department, Hospital Universitario de Bellvitge, Barcelona, Spain, Barcelona, Catalonia, Spain, 30Hospital San Cecilio, Granada, Andalucia, Spain, 31HU Arrixaca, Murcia, Spain, 32Hospital San Cecilio, Granada, Spain, 33HU San Cecilio, Granada, Spain, 34Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 35Hospital de Sierrallana, Torrelavega, Cantabria, Spain, 36Hospital Universitario Lucus Augusti, Lugo, Galicia, Spain, 37Rheumatology Unit, Basurto University Hospital, Bilbao, Spain, Bilbao, Spain, 38HU Araba, Vitoria, Spain, 39HU Puerta del Mar, Cadiz, 40HU Navarra, Pamplona, Spain, 41Hospital Universitario San Agustín, Avilés, Asturias, Spain, 42Rheumatology Department. Hospital Rio Carrión, Palencia, Spain, 43HU Lozano Blesa, Zaragoza, 44H Virgen de la salud, Toledo, Spain, 45HU Canarias, Tenerife, Spain, 46HU Malaga., Malaga, 47Hospital Negrin, Tenerife, 48H Huesca, HUesca, 49Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 50Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain

    Background/Purpose: Interstitial Lung Disease (ILD) is a severe extraarticular manifestation of rheumatoid arthritis (RA).Interstitial lung disease (ILD) associated with Rheumatoid Arthritis (RA) has a poor…
  • Abstract Number: 1734 • 2018 ACR/ARHP Annual Meeting

    Association of Short-Term Longitudinal Changes in Clinical and Physiologic Variables with Overall Survival in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD)

    Vincent Sobanski1, Jeska de Vries-Bouwstra2, Anna-Maria Hoffmann-Vold3, Dörte Huscher4, Margarida Alves5, Marco Matucci-Cerinic6, Gabriela Riemekasten7, Mengtao Li8, Gabriele Valentini9, László Czirják10, Otylia Kowal-Bielecka11, Yannick Allanore12, Nils Schoof5 and Oliver Distler13, 1Department of Internal Medicine and Clinical Immunology, University of Lille, Lille, France, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo University Hospital, Oslo, Norway, 4Charité – Universitaetsmedizin Berlin and Berlin Institute of Health, Berlin, Germany, 5Boehringer Ingelheim International GmbH, Ingelheim, Germany, 6Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 7Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, 8Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 9Department of Rheumatology, Second University of Naples, Napoli, Italy, 10Department of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, 11Department of Rheumatology and Internal Medicine, Medical University of Białystok, Białystok, Poland, 12Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, 13Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of morbidity and mortality in patients with SSc. However, the impact of changes in…
  • Abstract Number: 1749 • 2018 ACR/ARHP Annual Meeting

    Long-Term Renal Outcome in Pulmonary-Limited Microscopic Polyangiitis

    Hironari Hanaoka, Harunobu Iida, Tomofumi Kiyokawa, Yukiko Takakuwa and Kimito Kawahata, Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Patients with pulmonary-renal or renal-limited microscopic polyangiitis (MPA) frequently manifested with rapidly progressive glomerular nephritis resulting in chronic renal failure if clinical response to…
  • Abstract Number: 1877 • 2018 ACR/ARHP Annual Meeting

    Specific Pneumoproteins Predict Progression of Interstitial Lung Disease in Systemic Sclerosis Patients Undergoing Treatment with Immunosuppression

    Elizabeth R. Volkmann1, Donald P. Tashkin1, Masataka Kuwana2, Ning Li3, Julio Charles4, Faye N. Hant5, Galina S. Bogatkevich6, Tanjina Akter6, Michael Roth7, Hyun J. Grace Kim8, Jonathan Goldin9, Dinesh Khanna10, Philip J. Clements11, Daniel E. Furst7, Robert Elashoff12, Rick Silver13 and Shervin Assassi14, 1University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 3Biomathematics, University of California, Los Angeles, Los Angeles, CA, 4University of Texas Health Science Center at Houston, Houston, TX, 5Rheumatology, Medical University of South Carolina, Charleston, SC, 6Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 7Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 8Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, 9Department of Radiological Sciences at UCLA, University of California, Los Angeles, David Geffen School of Medicine, Santa Monica, CA, 10Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 11Medicine, University of California, Los Angeles, Los Angeles, CA, 12University of California, Los Angeles, Los Angeles, CA, 13Rheumatology, Medical University of SC, Charleston, SC, 14University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in systemic sclerosis (SSc). While some SSc-ILD patients are stable or improve with immunosuppressive…
  • Abstract Number: 2015 • 2018 ACR/ARHP Annual Meeting

    Association of Anti-Ro52 Autoantibodies with Interstitial Lung Disease and More Severe Disease Manifestations in Juvenile Idiopathic Inflammatory Myopathies

    Sara Sabbagh1, Iago Pinal-Fernandez1, Takayuki Kishi2, Ira N. Targoff3, Frederick W. Miller2, Lisa G. Rider2 and Andrew Mammen1,4, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2National Institute of Environmental Health Sciences, National Institutes of Health, Environmental Autoimmunity Group, Bethesda, MD, 3VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA) found in adult and juvenile idiopathic inflammatory myopathies (JIIM) often confer a specific disease phenotype.…
  • Abstract Number: 2257 • 2018 ACR/ARHP Annual Meeting

    Prevalence and Distinct Clinical Phenotype of Concomitant Sarcoidosis in Other Autoimmune Rheumatic Diseases

    Kristina E.N. Clark1, Huw Beynon2, Christopher P. Denton3 and Voon H. Ong4, 1Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Department of Rheumatology, Royal Free Hospital, London, United Kingdom, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Lung involvement is common in both sarcoidosis (up to 90%) and autoimmune rheumatic diseases (ARDs). Case reports have suggested distinct clinical manifestations when sarcoidosis…
  • Abstract Number: 375 • 2018 ACR/ARHP Annual Meeting

    Only a Minor Proportion of Individuals with Anti-Aminoacyl-tRNA Synthetase Autoimmunity Presents with the Clinical Picture of “Antisynthetase-Syndrome”

    Johannes Knitza, Hannah Schenker, Georg Schett and Jörg Distler, Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Antisynthetase Syndrome is a rare and severe autoimmune inflammatory disease that is associated with autoimmunity against aminoacyl-tRNA synthetase and clinical signs of arthritis, myositis…
  • Abstract Number: 2422 • 2018 ACR/ARHP Annual Meeting

    Pregnancy Outcomes in Patients with Interstitial Lung Disease Related to Autoimmune Disease and Sarcoidosis

    Stephanie L. Giattino, Amanda M. Eudy and Megan E. B. Clowse, Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC

    Background/Purpose: Currently published data regarding pregnancy outcomes in patients with interstitial lung disease (ILD) related to autoimmune disease and sarcoidosis is limited, with widely variant…
  • Abstract Number: 384 • 2018 ACR/ARHP Annual Meeting

    Patients with Anti-Synthetase Syndrome Have a Similar Prevalence and Severity of Interstitial Lung Disease to Systemic Sclerosis

    Bret Sohn1, Narender Annapureddy2, Rosemarie Dudenhofer3, April Barnado1, Leslie Crofford1 and Erin Wilfong4, 1Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, 4Division of Rheumatology and Immunology, Vanderbilt Unversity Medical Center, Nashville, TN

    Background/Purpose: Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in connective tissue diseases (CTDs). The purpose of this study is to…
  • Abstract Number: 2708 • 2018 ACR/ARHP Annual Meeting

    Current Management of Early Diffuse Cutaneous Systemic Sclerosis in US Scleroderma Centers

    Rebecca B. Blank1, Jessica K. Gordon2, Jackie Szymonifka3, Shervin Assassi4, Elana J. Bernstein5, Flavia V. Castelino6, Robyn T. Domsic7, Faye N. Hant8, Monique Hinchcliff9, Kate Homer10, Ami A. Shah11, Victoria Shanmugam12, Virginia D. Steen13, Tracy M. Frech14 and Dinesh Khanna15, 1Internal Medicine, New York Presbyterian-Weill Cornell Hospital, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY, 3Hospital for Special Surgery, New York, NY, 4University of Texas McGovern Medical School, Houston, TX, 5Rheumatology, Columbia University, New York, NY, 6Rheumatology, Harvard Medical School, Boston, MA, 7Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 8Rheumatology, Medical University of South Carolina, Charleston, SC, 9Division of Rheumatology, Northwestern University Medical School, Chicago, IL, 10Department of Internal Medicine, Rheumatology Division, Scleroderma Program, University of Michigan, Ann Arbor, MI, 11Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 12Rheumatology, The George Washington University, Washington, DC, 13Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 14Division of Rheumatology, University of Utah, Salt Lake City, UT, 15Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: Standard treatment for the diverse aspects of diffuse cutaneous systemic sclerosis (dcSSc) is not yet well defined although experts have described therapeutic algorithms.  The…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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