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Abstracts tagged "interstitial lung disease"

  • Abstract Number: 0062 • ACR Convergence 2024

    Pro-Fibrotic Effects of Malondialdehyde-Acetaldehyde-Adducted and/or Citrullinated Proteins on Macrophages and Human Lung Fibroblasts

    Lauren Klingemann1, Nozima Aripova1, Nigina Aripova2, Michael Duryee1, Carlos Hunter1, Jill Poole1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2WUSTL, St. Louis, MO

    Background/Purpose: Clinically evident rheumatoid arthritis-associated interstitial lung disease (RA-ILD) affects approximately 10-15% of patients with rheumatoid arthritis (RA) and accounts for the most overrepresented cause…
  • Abstract Number: 0348 • ACR Convergence 2024

    Upadacitinib in Interstitial Lung Disease Associated with Idiopathic Inflammatory Myopathies

    Ting Zhang1, Qiyuan Wang2, Wenjia Sun3, Lei Liu1 and Jing Xue4, 1Zhejiang University, Hangzhou, China (People's Republic), 2Zhejiang Univerisity, Hangzhou, China (People's Republic), 3The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China (People's Republic), 4The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)

    Background/Purpose: Interstitial lung disease (ILD) is one of the most severe complications in idiopathic inflammatory myopathies (IIM), substantially contributing to the morbidity and mortality. ILD…
  • Abstract Number: 0801 • ACR Convergence 2024

    Neutrophil Activation as a Novel Marker of Lung Disease in Rheumatoid Arthritis

    Jia Shi1, Yang Wu1, Ting Wang2, Chen Yu3, qian wang4, Xinping Tian5, Mengtao Li4, Kristen Demoruelle6, Joshua Solomon7 and Christian Lood2, 1University of Washington, Seattle, 2University of Washington, Seattle, WA, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Cheng Qu, China (People's Republic), 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7National Jewish Health, Denver, CO

    Background/Purpose: Neutrophil activation is seen in rheumatoid arthritis (RA), but its involvement in RA interstitial lung disease (RA-ILD) is not clear. Levels of N-formyl methionine…
  • Abstract Number: 0978 • ACR Convergence 2024

    Associations of Fire Smoke and Other Pollutants with Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Vanessa Kronzer1, Yangyuna Yang2, Punyasha Roul3, James Crooks4, Cynthia Crowson1, John Davis1, Jeffrey Sparks5, Jeffrey Pierce6, Katelyn O'Dell7, Sauer brian8, grant Cannon9, Joshua Baker10, Ted Mikuls2 and Bryant England2, 1Mayo Clinic, Rochester, MN, 2University of Nebraska Medical Center, Omaha, NE, 3UNMC, Omaha, NE, 4National Jewish Health, Denver, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 6Colorado State University, Fort Collins, 7George Washington University, Washington DC, 8Salt Lake City VA/University of Utah, Salt Lake City, UT, 9University of Utah and Salt Lake City VA, Salt Lake City, UT, 10Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Wildfires have burned increasing acreage in the United States (US) since the 1980s, releasing record and alarming levels of particulate matter smaller than 2.5…
  • Abstract Number: 1425 • ACR Convergence 2024

    Sjögren’s Syndrome and Interstitial Lung Disease: Experience in a Collaborative Rheumatology-Pulmonology Clinic

    Sonia Jiménez Barrios1, Sandra Garrote Corral2, Juan Rigual3, Carlos de La Puente Bujidos3, Maria Angeles Blazquez Canamero4 and Jesús Loarce3, 1Hospital Universitario Ramón y Cajal, Madrid, Madrid, Spain, 2Hospital Universitario Ramón y Cajal, Madrid, Spain, 3Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 4Hospital Ramon y Cajal, Madrid, Madrid, Spain

    Background/Purpose: Pulmonary lung disease represents the most prevalent extra-glandular manifestation in patients with Sjögren’s syndrome (SS). Notably, interstitial lung disease (ILD) stands out as the…
  • Abstract Number: 1736 • ACR Convergence 2024

    Effectiveness and Safety of Tofacitinib vs. Calcineurin Inhibitor in Interstitial Lung Disease Secondary to Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis: A Multi-Center Cohort Study with Propensity Score-Based Inverse Probability of Treatment Weighting

    Wanlong Wu1, Bingpeng Guo2, Wenjia Sun3, Dan Chen4, Wenwen Xu5, Zhiwei Chen5, Yakai Fu5, Yan Ye5, Xia Lyu6, Zhixin Xue5, Kaiwen Wang5, Jiangfeng Zhao7, Chunhua Ye5, Min Dai5, Wei Fan5, Jia Li5, Xiaodong Wang5, Yu Xue8, Weiguo Wan8, Li Sun4, Huaxiang Wu9, Qun Luo2, Qian Han2, Qiong Fu1 and Shuang Ye1, 1Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic), 2State Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (People's Republic), 3The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China (People's Republic), 4The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (People's Republic), 5Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic), 6Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China (People's Republic), 7Department of Rheumatology, Jiading Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic), 8Department of Rheumatology, Huashan Hospital, Fudan University, shanghai, China (People's Republic), 9Department of Rheumatology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China (People's Republic)

    Background/Purpose: The current management of anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5+DM) is challenging and largely empirical rather than evidence-based. Small-sized proof-of-concept trial and case series…
  • Abstract Number: 2276 • ACR Convergence 2024

    Use of Methotrexate and TNF-α Inhibitors in Patients with Rheumatoid Arthritis-associated Interstitial Lung Disease: A Survey of Rheumatologists

    Elizabeth Park1, Rabia Iqbal2, Elana Bernstein3 and Jon Giles4, 1Columbia University Medical Center, New York, NY, 2Columbia University Irving Medical Center, Brooklyn, NY, 3Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 4Cedars Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Interstitial lung disease (ILD) is among the most common extra-articular manifestations of RA, with symptomatic disease prevalent in approximately 10% of patients.1 Patients with…
  • Abstract Number: 2661 • ACR Convergence 2024

    Changes in Krebs Von Den Lungen 6 Levels (∆KL6) Predict Fibrosing Progression of Interstitial Lung Disease in Patients with an Underlying Connective Tissue Disease (CTD-ILD)

    Fredeswinda Romero-Bueno1, María Carmen Vegas-Sánchez2, lydia Abasolo Alcazar3, Mª Jesus Rodriguez Nieto2, Cristina Vadillo-Font4, M Asuncion Nieto5, Laura Cebrián6, Belén López-Muñiz6, Jesus Loarce Martos7, Juan Rigual8, hildegarda Godoy Tundidor9, Rosalía Laporta10, Irene Llorente-Cubas11, Gema Bonilla12, Luis Gomez Carrera13, Rosario García-Vicuña14, Ana Jaureguizar7, Jose Luis Morell Hita7, Claudia Valenzuela15 and Olga Sánchez-Pernaute16, and the NEREA Study group for Autoimmune ILD, 1Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain, 2Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, 3IdISSC. HCSC, Madrid, Spain, 4Hospital Clinico S Carlos, Madrid, Spain, 5Hospital Clínico San Carlos, Madrid, Madrid, Spain, 6Hospital Universitario Infanta Leonor, Madrid, Spain, 7Hospital Universitario Ramón y Cajal - IRYCIS, Madrid, Spain, 8Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 9Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, 10Hospital Universitario Puerta de Hierro, Madrid, Spain, 11Hospital Universitario de La Princesa, Madrid, Spain, 12H. Universitario La Paz, Madrid, Spain, 13Hospital Universitario La Paz, Madrid, Spain, 14Hospital Universitario de la Princesa, Madrid, Madrid, Spain, 15Hospital Universitario La Princesa, Madrid, Spain, 16Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain

    Background/Purpose: Krebs von den Lungen-6 (KL6) is a mucin-1 glycoprotein produced by type 2 alveolar epithelial cells , which increase at peripheral blood show a…
  • Abstract Number: 0154 • ACR Convergence 2024

    Chronic Sinusitis Predicting Interstitial Lung Disease in Sjögren’s Syndrome: A Comprehensive USA Population Study (2004-2024)

    Brian Schonewald1, Ross summer2, Giorgos Loizidis2 and Christopher Xie3, 1Thomas Jefferson University Hospital, Ardmore, PA, 2Thomas Jefferson University, Philadelphia, PA, 3Thomas Jefferson University, Philadelphia

    Background/Purpose: Sjögren's syndrome (SS) is a chronic autoimmune disorder primarily affecting the exocrine glands, but it also impacts various parts of the respiratory system, including…
  • Abstract Number: 0470 • ACR Convergence 2024

    New Approach for Early and Accurate Diagnosis of Rheumatoid Arthritis-related Interstitial Lung Disease: Matrix Metalloproteinases 7 and 9 as Novel Blood Biomarkers

    Veronica Pulito-Cueto1, Belén Atienza-Mateo2, gonzalo Ocejo-Viñals3, Victor M. Mora-Cuesta4, David Iturbe-Fernández4, Joao Carlos Batista-Liz1, María Sebastián Mora-Gil5, Mónica Renuncio-García6, Elena González López3, José M. Cifrián7, Ricardo Blanco-Alonso8 and Raquel Lopez-mejias1, 1IDIVAL, Santander, Spain, 2Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 3Department of Immunology, Marqués de Valdecilla University Hospital (HUMV), Santander, Spain, 4Immunopathology Group, Valdecilla Research Institute (IDIVAL) and Department of Pneumology, Marqués de Valdecilla University Hospital (HUMV), Santander, 5Immunopathology Group, Valdecilla Research Institute (IDIVAL) and Department of Rheumatology, Marqués de Valdecilla University Hospital (HUMV), Santander, 6Division of Immunology, Hospital Universitario Marqués de Valdecilla, Immunopathology Group, IDIVAL, Santander, Spain, 7Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. Immunopathology group, IDIVAL, Santander, 8Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is one of the main causes of death in rheumatoid arthritis (RA) patients [1]. Early diagnosis of RA-ILD+ is critical…
  • Abstract Number: 0802 • ACR Convergence 2024

    Disease Activity Is Strongly Associated with RA-related Lung Disease and Interstitial Lung Disease in Early RA: Results from a Multicenter, Prospective Cohort Study

    Gregory McDermott1, Ritu Gill2, Suzanne Byrne3, Staci Gagne3, Xiaosong Wang4, Misti Paudel5, Emily Kowalski3, Grace Qian4, Katarina Bade3, Kevin Mueller3, Alene Saavedra3, Kathleen Vanni3, Caleb Bolden6, Tina Mahajan7, Erica Mulcaire-Jones8, Neda Kortam8, Pierre-Antoine Juge9, Tracy J Doyle10, Zachary Wallace11, Marcy Bolster6, Kevin Deane12, Dinesh Khanna8, Bryant England7 and Jeffrey Sparks13, 1Brigham and Women's Hospital, Brookline, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women’s Hospital, Boston, MA, 5Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 6Massachusetts General Hospital, Boston, MA, 7University of Nebraska Medical Center, Omaha, NE, 8University of Michigan, Ann Arbor, MI, 9Departement of Rheumatology, AP-HP, Bichat Hospital, Boston, MA, 10Brigham and Women's Hospital, West Roxbury, MA, 11Massachusetts General Hospital, Newton, MA, 12University of Colorado Denver Anschutz Medical Campus, Aurora, CO, 13Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA

    Background/Purpose: RA is associated with several forms of lung disease including interstitial lung disease (ILD), bronchiectasis, and emphysema. Risk factors for the development and progression…
  • Abstract Number: 1007 • ACR Convergence 2024

    Demographic, Social, and Disease Factors Associated with Interstitial Lung Disease and Disease-Related Death in Dermatomyositis

    Connor Buechler, Lindsey Wanberg, Nawang Singhe, Cody Rasner, Joseph McGrath, Ziou Jiang, Karen Baker-James and David Pearson, University of Minnesota, Minneapolis, MN

    Background/Purpose: Dermatomyositis (DM) is associated with significant morbidity and mortality due to disease-related progressive interstitial lung disease (ILD) and malignancy. However, little is known about…
  • Abstract Number: 1571 • ACR Convergence 2024

    Growth Differentiation Factor 15 Is a Serum Biomarker and Pathogenic Factor of Progressive Fibrosis in Systemic Sclerosis

    Vishal Kakkar1, Sunhwa Kim2, Yingtao Bi3, Christopher Wasson1, Stefano Di Donato4, Rebecca Ross5, Marco Di Battista6, Enrico De Lorenzis7, Thierry Sornasse2 and Francesco Del Galdo1, 1University of Leeds, Leeds, United Kingdom, 2AbbVie, South San Francisco, CA, 3Abbvie, Worcester, MA, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK, Leeds, United Kingdom, 5Medicine and Health, University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds, UK, Pisa, United Kingdom, 7Catholic University of the Sacred Heart, Roma, Rome, Italy

    Background/Purpose: In systemic sclerosis (SSc), interstitial lung disease (ILD) remains the leading cause of mortality. A decline in forced vital capacity (FVC) is considered a…
  • Abstract Number: 1894 • ACR Convergence 2024

    Detection of Fibrotic Lung Changes and Bronchiectasis in RA Patients Screened for Lung Cancer with Low-dose CT Chest: Results from a Large Multi-hospital System

    Gregory McDermott1, Mark Hammer2, Xiaosong Wang3, Misti Paudel4, Sung Hae Chang5, Pierre-Antoine Juge6, Qianru Zhang7, Jessica Lorusso8, Amie Samulyov8, Kathleen Vanni2, Alene Saavedra2, Emily Kowalski2, Grace Qian3, Katarina Bade2, Kevin Mueller2, Jeffrey Sparks9 and Suzanne Byrne2, 1Brigham and Women's Hospital, Brookline, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA, 4Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 5Soonchunhyang University College of Medicine, Bongmyeong-dong, Dongnam-gu, Cheonan-si, South Korea, 6Departement of Rheumatology, AP-HP, Bichat Hospital, Boston, MA, 7Harard Medical School, Cambridge, 8Mass General Brigham, Boston, MA, 9Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA

    Background/Purpose: Cigarette smoking is a risk factor for both lung cancer and RA. Furthermore, RA is associated with pulmonary abnormalities including interstitial lung disease, bronchiectasis,…
  • Abstract Number: 2284 • ACR Convergence 2024

    Real-World Evidence of the Antifibrotic Nintedanib in Rheumatoid Arthritis-Interstitial Lung Disease. National Multicenter Study of 74 Patients from Clinical Practice

    Belén Atienza-Mateo1, Ana Serrano-Combarro2, Jesús Loarce3, Nuria Vegas Revenga4, María Martín López5, Santos Castañeda6, Rafael Benito Melero-Gonzalez7, Natalia Mena Vázquez8, Carmen Carrasco-Cubero9, Carolina Díez Morrondo10, David Castro-Corredor11, Tomás Vázquez Rodríguez12, Andrea García-Valle13, Gema Bonilla14, Marina Rodriguez15, Ignacio Brana Abascal16, Sara María Rojas Herrera17, Juan Camilo Sarmiento-Monroy18, Pablo Andújar-Brazal19, Diego Ferrer20 and Ricardo Blanco-Alonso21, and Rest of the Members of the Spanish Collaborative Group of Antifibrotics in Interstitial Lung Disease Associated with Rheumatoid Arthritis, 1Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 3Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 4Hospital Galdakao- Usansolo, Galdakao, Spain, 5General University Hospital of Ciudad Real, Ciudad de México, Spain, 6Hospital Universitario de la Princesa, Madrid, Spain, 7CHU Ourense, O Carballino, Spain, 8IBIMA, Málaga, Andalucia, Spain, 9Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain, 10Complejo Asistencial Universitario de Leon, Leon, 11General University Hospital of Ciudad Real, Santa Cruz de Mudela (Ciudad Real), Spain, 12Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain, 13Hospital General Río Carrión, Palencia, Spain, 14H. Universitario La Paz, Madrid, Spain, 15Hospital Clínico Universitario de Santiago, La Coruna, Spain, 16Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain, 17Hospital de Mérida, Badajoz, Spain, 18Hospital Clínic Barcelona, Barcelona, Spain, 19Hospital Universitario Doctor Peset, Valencia, Spain, 20Division of Pneumology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 21Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a serious complication of rheumatoid arthritis (RA), with a prevalence that ranges from 7 to 30% patients with RA,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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