Abstracts tagged "interstitial lung disease and systemic sclerosis"

Abstract Number: 3001 • 2015 ACR/ARHP Annual Meeting
Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis
Angel CY Mak¹, Paul LF Tang², Clare Cleveland^3,4, M Kari Connolly⁵, Tamiko Katsumoto^3,4, Paul Wolters⁶, Pui-Yan Kwok^2,5 and Lindsey A. Criswell⁷, ¹Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, ²Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA, ⁴Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁵Department of Dermatology, University of California, San Francisco, San Francisco, CA, ⁶Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Scleroderma is a genetically complex autoimmune disease with substantial phenotypic heterogeneity. Previous genome-wide association studies (GWAS) have identified a large number of gene regions…
Abstract Number: 2995 • 2014 ACR/ARHP Annual Meeting
Surrogate Measures of Extent of Interstitial Lung Disease As Measured By Quantitative Radiographic Analysis in Patients with Systemic Sclerosis
Elizabeth Volkmann¹, Donald Tashkin², Chi-hong Tseng¹, Kim Hyun³, Jonathan Goldin³, Philip J. Clements⁴, Daniel E. Furst¹, Dinesh Khanna⁵, Eric Kleerup¹, Michael Roth¹ and Robert Elashoff⁶, ¹Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Medicine, University of California at Los Angeles, Los Angeles, CA, ³Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁵University of Michigan Health System, Ann Arbor, MI, ⁶Biomathematics, University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Extent of systemic sclerosis (SSc)-related interstitial lung disease (ILD) predicts disease course, mortality and treatment response. While quantitative analyses of total extent of ILD…
Abstract Number: 1702 • 2014 ACR/ARHP Annual Meeting
Antiphospholipid Antibodies in Systemic Sclerosis: Prevalence and Clinical Significance?
Anjali Shetty¹, Suncica Volkov¹, Claudia Vergara² and William Swedler³, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Rheumatology, University of Illinois Chicago, Chicago, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by collagen deposition and vascular changes of the skin and internal organs, leading ultimately to fibrosis. …
Abstract Number: 744 • 2014 ACR/ARHP Annual Meeting
Integrin Inhibitor Modulates Pulmonary Fibrosis in the Reactive Oxygen Species Murine Model of Systemic Sclerosis
Gianluca Bagnato¹, Alessandra Bitto², Natasha Irrera², Gabriele Pizzino², Neal Roberts³, Domenica Altavilla², Francesco Squadrito², Antonino Saitta⁴ and Gianfilippo Bagnato⁵, ¹Rheumatology, University of Messina, Messina, Italy, ²Pharmacology, University of Messina, Messina, Italy, ³University of Louisville, Louisville, KY, ⁴Internal Medicine, University of Messina, Messina, Italy, ⁵Via C. Colombo, 41, Universita Messina, Villafranca Tirrena, Italy
Background/Purpose: Systemic sclerosis (SSc) is an acquired connective tissue disorder in which inflammation, immune dysregulation and vascular damage lead to fibroblast activation that results in…
Abstract Number: 729 • 2014 ACR/ARHP Annual Meeting
A Dilated Esophagus Is an Independent Risk Factor for Interstitial Lung Disease in SSc
Carrie Richardson¹, Rishi Agrawal², Jungwha Lee³, Orit Almagor⁴, John Varga⁵, Rowland W. Chang⁶ and Monique E. Hinchcliff⁷, ¹Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, ²Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose High-resolution computed tomography of the chest (HRCT) performed for assessment of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) frequently reveals a…

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