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Abstracts tagged "interstitial lung disease and synthetase syndrome"

  • Abstract Number: 1908 • ACR/ARHP Annual Meeting 2016

    Identification of a Novel Pro-Inflammatory T Cell Epitope from His-tRNA-Synthetase Associated with Interstitial Lung Disease in Anti-Jo-1 Positive Patients

    Angeles Shunashy Galindo-Feria1, Inka Albrecht2, Antonella Notarnicola2, Maryam Dastmalchi2, Anatoly Dubnovitsky3, Tatiana Sandalova3, Genadiy Kozhukh3, Lars Rönnblom4, Adnane Achour5, Vivianne Malmström6 and Ingrid E. Lundberg2, 1Department of Medicine., Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine Solna and Department of Infectious Diseases,, Science for Life Laboratory, Karolinska Institutet and Karolinska University Hospital, Solna, Sweden, 4Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, 5Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 6Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Previous studies have demonstrated that CD4+ T cells from peripheral blood of anti-histidyl-tRNA synthetase (anti-His-tRNA) also known as anti-Jo-1 positive patients proliferate in response…

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