Abstracts tagged "interleukins (IL) and systemic sclerosis"

Abstract Number: 768 • 2017 ACR/ARHP Annual Meeting
A Positive Feedback Loop between Estrogen and IL-6 Leads to Fibrosis in Human Skin
DeAnna Baker Frost¹ and Carol A. Feghali-Bostwick², ¹Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC
Background/Purpose: Systemic Sclerosis (SSc) is a disease characterized by an increase in the synthesis of extracellular matrix (ECM) components in various organs, including the skin,…
Abstract Number: 1925 • 2015 ACR/ARHP Annual Meeting
Interleukin-35 Is Upregulated in Systemic Sclerosis and Its Serum Levels Are Increased in Early Disease
Michal Tomcík¹, Pawel Zerr², Katrin Palumbo-Zerr², Hana Storkanova¹, Hana Hulejova³, Maja Spiritovic⁴, Ondrej Kodet⁵, Jiri Stork⁵, Radim Becvar¹, Jiri Vencovsky¹, Karel Pavelka⁶, Maria Filkova⁷, Jorg HW Distler² and Ladislav Senolt⁸, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, ⁵Department of Dermatology and Venereology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁶Charles University, Prague, Czech Republic, ⁷Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁸Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin-35 (IL-35) is the most recent addition to the IL-12 family, which also comprises IL-12, IL-23 and IL-27. IL-35 consists of two chains, p35/IL-12a…
Abstract Number: 2991 • 2015 ACR/ARHP Annual Meeting
Evaluation of Serum Levels of Adipokines and Interleukines in Pericardial Effusion Related to Systemic Sclerosis
Angela Chialà¹, Cinzia Rotondo¹, Maria Grazia Anelli¹, Emanuela Praino¹, Luca Cantarini², Crescenzio Scioscia¹, Margherita Giannini¹, Giovanni Lapadula¹ and Florenzo Iannone¹, ¹DIM, Rheumatology Unit, Bari, Italy, ²Univ Siena, Siena, Italy
Background/Purpose: Pericardial involvement is common in rheumatic disease, as rheumatoid arthritis, lupus erythematosus, mixed connective disease and systemic sclerosis. Few data are available about pathogenesis…
Abstract Number: 3017 • 2015 ACR/ARHP Annual Meeting
TYK2 and Systemic Sclerosis Susceptibility: a New Associated Locus in the IL-12 Pathway
Elena Lopez-Isac¹, Lara Bossini-Castillo², Sandra G Guerra³, Shervin Assassi⁴, Carmen P. Simeón⁵, Patricia E. Carreira⁶, Norberto Ortego-Centeno⁷, Paloma García de la Peña⁵, Lorenzo Beretta⁸, Alessandro Santaniello⁹, Chiara Bellocchi¹⁰, Claudio Lunardi¹¹, Gianluca Moroncini¹², Armando Gabrielli¹³, Gabriela Riemekasten¹⁴, Torsten Witte¹⁵, Nicolas Hunzelmann¹⁶, Alexander Kreuter¹⁷, Jorg HW. Distler¹⁸, Alexandre E. Voskuyl¹⁹, J.K. de Vries-Bouwstra²⁰, Ariane L. Herrick²¹, Jane Worthington²², Christopher P. Denton²³, Carmen Fonseca³, T.R.D.J. Radstake²⁴, Maureen D Mayes²⁵ and Javier Martín¹, ¹Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain, ³Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁴Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁵Rheumatologist, Granada, Spain, ⁶Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁷Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, ⁸Rheumatology, Milan, Italy, ⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and University of Milan, Italy, Milan, Italy, ¹⁰Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹¹Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹²Dipartimento di Scienze mediche e Chirurgiche, Università politecnica delle Marche, Ancona, Italy, ¹³Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ¹⁴Clinic of Rheumatology and Clinical Immunology, Berlin, Germany, ¹⁵Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹⁶Department of Dermatology, University of Cologne, Cologne, Germany, ¹⁷Department of Dermatology, Venereology, and Allergologie, HELIOS St. Elisabeth Hospital, Oberhausen, Germany, ¹⁸Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ¹⁹Rheumatology, Amsterdam Rheumatology and immunology Center, location VU University medical center, Amsterdam, Netherlands, ²⁰Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²¹Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²³Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ²⁴Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²⁵University of Texas - Houston Medical School, Houston, TX
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease. The aetiology of the disease is largely unknown, although both environmental and a genetic factors are…

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