Abstracts tagged "interleukins (IL) and spondylarthropathy"

Abstract Number: 725 • ACR/ARHP Annual Meeting 2012
The Role of Interleukin-23 in Spondyloarthropathy
Jonathan Sherlock¹, Barbara Joyce-Shaikh¹, Scott Turner¹, Cheng-Chi Chao², Manjiri Sathe¹, Jeff Grein¹, Dan Gorman¹, Eddie P. Bowman², Terrill McClanahan¹, Jennifer Yearley¹, Gerard Eberl³, Christopher D. Buckley⁴, Robert Kastelein¹, Robert Pierce¹, Drake LaFace¹ and Daniel Cua⁵, ¹Merck, Palo Alto, CA, ²Drug Discovery, Merck, Palo Alto, CA, ³Institut Pasteur, Paris, France, ⁴Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁵Discovery Research, Merck Research Laboratory, Palo Alto, CA
Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone. Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…