ACR Meeting Abstracts

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Abstracts tagged "interleukins (IL) and rheumatoid arthritis"

  • Abstract Number: 467 • 2016 ACR/ARHP Annual Meeting

    Interleukin-21-Signaling in B Cells, but Not in T Cells, Is Indispensable for Development of Collagen-Induced Arthritis in Mice

    Koji Sakuraba1,2, Kenjiro Fujimura1,2, Hisaaki Miyahara1 and Hisakata Yamada2, 1Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, 2Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    Background/Purpose:  IL-21 is a T cell-derived cytokine whose receptor is expressed on variety of cells in immune system. IL-21was reported to be involved in the…
  • Abstract Number: 2351 • 2014 ACR/ARHP Annual Meeting

    Ligand of Glucocorticoid-Induced Tumor Necrosis Factor Receptor Enhances Th17 Cells Response in Collagen-Induced Arthritis Via P38 MAPK and STAT3 Pathway

    Xinyi Tang1 and Shengjun Wang2, 1Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, 2Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China

    Background/Purpose Helper T lymphocyte-17 (Th17) has recognized to be an important factor in rheumatoid arthritis (RA) pathogenesis. The natural ligand of glucocorticoid-induced tumor necrosis factor…
  • Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting

    Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model

    Joong Kyong Ahn1, Jaejoon Lee2, Hyemin Jeong2, Jiwon Hwang2, Seulkee Lee2, Ji Young Chai3, Inyoung Kim2,4, Eun Chung Hong5, Eun-Kyung Bae5, Hoon-Suk Cha2 and Eun-Mi Koh2, 1Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 3Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, 4MD, Seoul, South Korea, 5Samsung Biomedical Research Institute, Seoul, South Korea

    Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…
  • Abstract Number: 831 • 2012 ACR/ARHP Annual Meeting

    A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, and Efficacy of Brodalumab (AMG 827) in Subjects with Rheumatoid Arthritis and an Inadequate Response to Methotrexate

    Karel Pavelka1, Yun Chon2, Richard Newmark2, Ngozi Erondu3 and Shao- Lee Lin2, 1Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University Prague, Prague, Czech Republic, 2Clinical Development, Amgen Inc, Thousand Oaks, CA, 3Amgen Inc, Thousand Oaks, CA

    Background/Purpose: A potential role for IL-17 in rheumatoid arthritis (RA) has been supported by data from clinical studies of inhibitors of the IL-17A ligand. To…
  • Abstract Number: 836 • 2012 ACR/ARHP Annual Meeting

    Clinical Responses and Patient Reported Outcomes to NNC0109-0012 (anti-IL-20 mAb) in Rheumatoid  Arthritis (RA) Patients Following 12-Weeks Dosing and 13 Weeks Follow up: Results From a Phase 2a Trial

    Ladislav ŠEnolt1, Marie Göthberg2, Xavier Valencia3 and Eva Dokoupilova4, 1Institute of Rheumatology, Prague, Czech Republic, 2Biostatistics, Novo Nordisk, A/S, Soeborg, Denmark, 3Clinical Medical and Regulatory Affairs, Novo Nordisk, Inc., Princeton, NJ, 4Medical Plus s.r.o, Uherske Hradiste, Czech Republic

    Background/Purpose: NNC0109-0012 (anti-IL-20 mAb) is a novel human monoclonal IgG4 antibody which binds to and neutralizes the activity of IL-20. Data from a phase 1…
  • Abstract Number: 2320 • 2012 ACR/ARHP Annual Meeting

    Superantigen Induces IL-17 Production From Extremely Polarized Th1 Clones

    Kentaro Yomogida1, Yuan K. Chou1 and Cong-Qiu Chu2, 1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 2Rheumatology, Oregon Health & Science Univ and Portland VA Medical Center, Portland, OR

    Background/Purpose: Differentiation of naïve CD4+ T cells is considered to be an irreversible event and, in particular, the plasticity is thought to be completely lost…
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ACR Pediatric Rheumatology Symposium 2020

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