Abstract Number: 467 • ACR/ARHP Annual Meeting 2016
Interleukin-21-Signaling in B Cells, but Not in T Cells, Is Indispensable for Development of Collagen-Induced Arthritis in Mice
Background/Purpose: IL-21 is a T cell-derived cytokine whose receptor is expressed on variety of cells in immune system. IL-21was reported to be involved in the…Abstract Number: 2351 • ACR/ARHP Annual Meeting 2014
Ligand of Glucocorticoid-Induced Tumor Necrosis Factor Receptor Enhances Th17 Cells Response in Collagen-Induced Arthritis Via P38 MAPK and STAT3 Pathway
Background/Purpose Helper T lymphocyte-17 (Th17) has recognized to be an important factor in rheumatoid arthritis (RA) pathogenesis. The natural ligand of glucocorticoid-induced tumor necrosis factor…Abstract Number: 2216 • ACR/ARHP Annual Meeting 2013
Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model
Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…Abstract Number: 2320 • ACR/ARHP Annual Meeting 2012
Superantigen Induces IL-17 Production From Extremely Polarized Th1 Clones
Background/Purpose: Differentiation of naïve CD4+ T cells is considered to be an irreversible event and, in particular, the plasticity is thought to be completely lost…Abstract Number: 836 • ACR/ARHP Annual Meeting 2012
Clinical Responses and Patient Reported Outcomes to NNC0109-0012 (anti-IL-20 mAb) in Rheumatoid Arthritis (RA) Patients Following 12-Weeks Dosing and 13 Weeks Follow up: Results From a Phase 2a Trial
Background/Purpose: NNC0109-0012 (anti-IL-20 mAb) is a novel human monoclonal IgG4 antibody which binds to and neutralizes the activity of IL-20. Data from a phase 1…Abstract Number: 831 • ACR/ARHP Annual Meeting 2012
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Evaluate the Safety, Tolerability, and Efficacy of Brodalumab (AMG 827) in Subjects with Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Background/Purpose: A potential role for IL-17 in rheumatoid arthritis (RA) has been supported by data from clinical studies of inhibitors of the IL-17A ligand. To…
ACR Meeting Abstracts