Abstracts tagged "interleukins (IL) and rheumatoid arthritis (RA)"

Abstract Number: 2049 • 2018 ACR/ARHP Annual Meeting
Expression and Function of a Novel Citrullinated Form of Interleukin 6 in Rheumatoid Arthritis
Chenyang Lu, Ray A. Ohara, Phillip L. Campbell, Yuxuan Du, W. Alexander Stinson, Jonatan Hervoso, Ellen Cealey, David Fox and M. Asif Amin, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by synovial hyperplasia, progressive joint destruction and the presence of anti-citrullinated peptide antibodies (ACPAs) in…
Abstract Number: 2544 • 2018 ACR/ARHP Annual Meeting
Changes of CD4-(CD8+) Regulatory T Cells in Rheumatoid Arthritis Patients and during Interleukin-2 Therapy
Xiaoxia Jia¹, Fang Li², Jing Luo³, Chong Gao⁴ and Xiao-Feng Li¹, ¹Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, ²Department of Rheumatology, the Second Hospital of Shanxi Medical University, Taiyuan, China, ³the Second Hospital of Shanxi Medical University, Taiyuan, China, ⁴Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, Cambridge, MA
Background/Purpose: Recent studies have showed that quantitative and/or functional abnormalities of the regulatory T cells (Tregs) may play a vital role in the development of…
Abstract Number: 1461 • 2017 ACR/ARHP Annual Meeting
The Relationship between Serum IL-37 and Disease Activity in Patients with Rheumatoid Arthritis: Post-Hoc Analysis of Planetra Study
Seoung Wan Nam¹, Hyuk Hee Kwon², Ga-Young Ahn³, Min Jung Kim² and Dae-Hyun Yoo¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)
The relationship between serum IL-37 and disease activity in patients with rheumatoid arthritis: post-hoc analysis of PLANETRA study. Background/Purpose: Rheumatoid Arthritis (RA) is a chronic…
Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting
The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression
Tue Wenzel Kragstrup^1,2,3, Stinne Greisen¹, Morten Aagaard Nielsen¹, Chris Rhodes², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁷, Malene Hvid^1,8, Thomas Vorup-Jensen¹, William H. Robinson^2,9, Jeremy Sokolove^2,10 and Bent Deleuran^1,3,8, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁵Rheumatology, Rheumatology King Christian X's Hospital, Graasten, Denmark, ⁶University of Southern Denmark, Odense, Denmark, ⁷Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁸Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁹Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹⁰Stanford University School of Medicine, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…
Abstract Number: 1932 • 2015 ACR/ARHP Annual Meeting
IL-17A-Low CCR6+ Th Cell Populations of Patients with Rheumatoid Arthritis Are Pathogenic, Multidrug Resistant and Associated with DMARD and Glucocorticoid Treatment Response
Jan Piet van Hamburg¹, Sandra M.J. Paulissen², Nadine Davelaar¹, Mieke Hazes³ and Erik Lubberts¹, ¹Rheumatology and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Room Nb-84, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Background/Purpose: CCR6+ T-helper (Th) cells and their pro-inflammatory cytokines including IL-17A are implicated in the pathogenesis of rheumatoid arthritis (RA). However, within the CCR6+ Th…
Abstract Number: 2708 • 2015 ACR/ARHP Annual Meeting
Correlation of Peripheral Blood Th-17 and Th-1 with Synovitis and Osteitis By MRI in Recent Onset Rheumatoid Arthritis
Sukesh Edavalath¹, Ankita Singh¹, Namita Mohindra², Sunil Kumar² and Ramnath Misra¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: An increased expansion of Th17 cells in the synovial membrane have shown to play a key role in causing persistent synovitis leading to cartilage…
Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting
Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis
Nataliya Yeremenko¹, Raquel Celis², Leonie M. van Duivenvoorde³, Julio Ramirez⁴, Iris C. Blijdorp⁵, Sara Marsal⁶, Jose L. Pablos⁷, Raimon Sanmarti⁴, Juan D. Cañete⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…
Abstract Number: 1749 • 2014 ACR/ARHP Annual Meeting
Molecular Mechanisms Underlying 1,25(OH)₂D₃-Mediated Suppression of Th17 Cell Activity
Wendy Dankers^1,2, Jan Piet van Hamburg^2,3, Wida Razawy^1,2, Nadine Davelaar^1,2, Anne-Marie Mus^1,2, Patrick Asmawidjaja^1,2, Johannes van Leeuwen⁴, Edgar Colin⁵ and Erik Lubberts^1,2, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Rheumatology, ZGT, Almelo, Netherlands
Background/Purpose Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). Within these diseases, Th17 cells play a crucial role in the…
Abstract Number: 1175 • 2014 ACR/ARHP Annual Meeting
Association of Hand MRI Findings with the Level of Plasma Cytokines in Patients with Newly Diagnosed Rheumatoid Arthritis
Yasushi Kondo¹, Yuko Kaneko¹, Hiroaki Sugiura², Shunsuke Matsumoto², Naoshi Nishina¹, Masataka Kuwana¹, Masahiro Jinzaki² and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Radiology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Magnetic resonance imaging (MRI) is a very useful modality that can directly visualize both inflammatory and structural changes of affected joints in patients with…
Abstract Number: 1039 • 2014 ACR/ARHP Annual Meeting
Interleukin-20 Is Triggered By TLR Ligands and Associates with Rheumatoid Arthritis Disease Activity
Ladislav Senolt¹, Klara Prajzlerova¹, Hana Hulejova², David Veigl³, Karel Pavelka¹ and Jiri Vencovsky¹, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, ³1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and subsequent joint damage with systemic manifestations. Interleukin-20 (IL-20) has been…
Abstract Number: 373 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Cardiac Dysfunction and Inflammation in Plasma Predict Occult Coronary Plaque Burden and Composition in Rheumatoid Arthritis
George A. Karpouzas¹, Joel Estis², John Todd² and Matthew Budoff³, ¹Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ²Singulex, Alameda, California, Alameda, CA, ³Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose Rheumatoid arthritis (RA) is associated with accelerated coronary atherogenesis, myocardial infarction, and mortality. We previously reported a higher prevalence, severity, and different composition of…
Abstract Number: 2347 • 2013 ACR/ARHP Annual Meeting
Functional Single Nucleotide Polymorphisms In The Interferon-γ and The NLRP3 (Cryopyrin) Genes Associated With Anti-TNF Response In Danish Rheumatoid Arthritis Patients
Jacob Sode^1,2,3, Niels H. H. Heegaard⁴, Henning Locht², Ulla Vogel⁵, Steffen Bank^6,7, Merete Lund Hetland^8,9 and Vibeke Andersen^3,7,10,11, ¹Clinical Biochemistry, Immunology and Genetics, Statens Serum Institut, Copenhagen S, Denmark, ²Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, ³Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁴Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁵National Research Centre for the Working Environment, Copenhagen, Denmark, ⁶Institute of Human Genetics, University of Aarhus, Aarhus, Denmark, ⁷Medical Department, Viborg Regional Hospital, Viborg, Denmark, ⁸The Danish Rheumatologic Database (DANBIO), Glostrup Hospital, Glostrup, Denmark, ⁹Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, ¹⁰Medical Department, Hospital of Southern Jutland Aabenraa, Aabenraa, Denmark, ¹¹Odense University Hospital, OPEN (Odense Patient data Explorative Network), Odense, Denmark
Background/Purpose: Most patients with rheumatoid arthritis (RA) benefit from tumor necrosis factor-a blocking treatment (anti-TNF). About 1/3, however, do not respond to this costly and…
Abstract Number: 959 • 2013 ACR/ARHP Annual Meeting
Interleukin 10 Negatively Correlates With Glycoprotein VI-Related Platelet Activation In Rheumatoid Arthritis (RA): A Novel Potential Target Of Cardiovascular Morbidity In RA
Leann Bell¹, Anne M. Madigan¹, Paul A. MacMullan¹, Eimear Dunne², Paola M. Bagaglia¹, Laura J. Durcan¹, Dermot Kenny² and Geraldine M. McCarthy¹, ¹Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ²Molecular and Cellular Therapeutics, RCSI, Dublin 2, Ireland
Background/Purpose: Patients with rheumatoid arthritis (RA) die prematurely of cardiovascular disease (CVD). Platelet mediated thrombosis is a major cause of CVD. Platelets amplify inflammation in RA via the collagen receptor,…
Abstract Number: 711 • 2013 ACR/ARHP Annual Meeting
1,25(OH)₂D₃ Inhibits Th17 Cytokine Production and RORγt Expression Through GATA3/IL4-Dependent and -Independent Mechanisms
Wendy Dankers¹, Jan Piet van Hamburg^2,3, Anne-Marie Mus¹, Patrick S. Asmawidjaja¹, Johannes van Leeuwen⁴, Rudi W. Hendriks⁵, Louis Boon⁶, Edgar Colin⁷ and Erik Lubberts^1,8, ¹Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁵Pulmonary Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁶Bioceros, Utrecht, Netherlands, ⁷Department of Rheumatology, ZGT, Almelo, Netherlands, ⁸Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Vitamin D has suppressive effects on autoimmune diseases, such as rheumatoid arthritis (RA). One important mechanism of disease suppression by vitamin D is inhibition…
Abstract Number: 434 • 2013 ACR/ARHP Annual Meeting
Results Of 64 Weeks Of Treatment With An Anti-IL-17 Antibody, Ixekizumab, In Patients With Rheumatoid Arthritis In a Phase 2 Study
Mark C. Genovese¹, Hilde Carlier², Janelle Erickson², Daniel Braun² and Subhashis Banerjee², ¹Division of Rheumatology, Stanford University, Palo Alto, CA, ²Eli Lilly & Company, Indianapolis, IN
Background/Purpose: Ixekizumab, a monoclonal antibody that neutralizes IL-17A with high affinity and specificity, has been evaluated in patients (pts) with moderate to severe rheumatoid arthritis…

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