Abstracts tagged "Interleukins (IL) and osteoclasts"

Abstract Number: 884 • 2012 ACR/ARHP Annual Meeting
Receptor Activator of Nuclear Factor ÊB Ligand-Mediated Osteoclastogenesis Is Augmented by Interleukin-1â Via up-Regulation of Endoplasmic Reticulum Stress Signals
Myong-Joo Hong¹, Myung-Soon Sung¹, Eun-Gyeong Lee¹, Yoon Kyung Hong¹, Chang-Hoon Lee², Myeung Su Lee³ and Wan-Hee Yoo⁴, ¹Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, ²Department of Internal Medicine, School of medicine, Wonkwang university, Iksan, Chonbuk, South Korea, ³Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, ⁴Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea
Background/Purpose: Interleukin-1β (IL-1β) and thapsigargin (TG)-augmented endoplasmic reticulum (ER) stress modulate the receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. However, the mechanism by…

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