Abstracts tagged "interleukins (IL) and matrix metalloproteinase (MMP)"

Abstract Number: 1124 • ACR/ARHP Annual Meeting 2016
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 1790 • ACR/ARHP Annual Meeting 2012
Notch Promotes Matrix Metalloproteinase 13 Expression by Inducing Interleukin-6 in Primary Murine Chondrocytes
Stefano Zanotti and Ernesto Canalis, Research, Saint Francis Hospital and Medical Center, Hartford, CT
Background/Purpose: Notch1 to Notch4 are transmembrane receptors that determine cell differentiation and function. Interactions of Notch with its ligands result in the cleavage of the…
Abstract Number: 12 • ACR/ARHP Annual Meeting 2012
Articular Cartilage Expresses the IL-15 Receptor Alpha-Chain and Responds to IL-15 with Increased Matrix Metalloproteinase Release
Anjali Nair¹, Michael Huvard², Madeline Rollins³, Arnavaz Hakimiyan⁴, Lev Rappaport⁴, Arkady Margulis⁴, Susanna Chubinskaya⁵ and Carla R. Scanzello⁶, ¹Section of Rheumatology, Rush University Medical Center, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Rush University Medical Center, Chicago, IL, ⁵Biochemistry, Rush University Medical Center, Chicago, IL, ⁶Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: IL-15, known for its effects on survival of lymphocyte subsets, plays a role in synovitis of Rheumatoid Arthritis. We reported that IL-15 is also…