ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Interleukins"

  • Abstract Number: 2344 • ACR Convergence 2024

    Secukinumab Retention and Effectiveness in Patients with Psoriatic Arthritis and Radiographic Axial Spondyloarthritis: 5-year Final Results of a Prospective Real-world Study

    Uta Kiltz1, Petros Sfikakis2, Andreas Bounas3, Nicola Gullick4, Eric LESPESSAILLES5, Jan Brandt Jürgens6, Rasho Rashkov7, Barbara Schulz8, Weibin Bao9, Piotr Jagiello10 and Karl Gaffney11, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-University, D-44649 Herne, Germany, 2Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens. Centre of New Biotechnologies and Precision Medicine (CNBPM), School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 3PRIVATE PRACTICE, Patra, Greece, 4Rheumatology Department, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, Coventry, United Kingdom, 5CHR ORLEANS, ORLEANS, France, 6Rheumatologische Schwerpunktpraxis, Berlin, Germany, 7Clinic of Rheumatology, University Hospital St. Ivan Rilski, Sofia, Bulgaria, 8GKM Gesellschaft für Therapieforschung mbH, Lessingstrasse, Munchen, Germany, 9Novartis Pharmaceuticals Corporation, East Hanover, NJ, 10Novartis Pharma AG, Basel, Switzerland, Basel, Switzerland, 11Health Care - NHS, Norwich, United Kingdom

    Background/Purpose: Real-world data on long-term use of secukinumab complements clinical trial findings by providing insights from diverse patients in routine clinical settings. SERENA (CAIN457A3403) was…
  • Abstract Number: 2355 • ACR Convergence 2024

    Efficacy of Risankizumab Across Distinct PsA Phenotypes Identified with Machine Learning Analytics Using Data from Biologic DMARD-Naive Patients in Two Phase 3 Clinical Trials

    Laure Gossec1, Andra Balanescu2, Maria Antonietta D'Agostino3, Alexis Ogdie4, Philipp Sewerin5, Yu Deng6, Linyu Shi6, Yoshiyuki Sugimoto7, Sheng Zhong6, Yunzhao Xing6, Ralph Lippe6 and Mitsumasa Kishimoto8, 1Sorbonne Université, Paris, France, 2UNIVERSITY OF MEDICINE AND PHARMACY CAROL DAVILA, Bucharest, Romania, 3Versailles-Saint-Quentin University (INSERM U1173, Laboratoire d’Excellence INFLAMEX); University Hospital Ambroise Paré, Versailles, France, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5Rheumazentrum Ruhrgebiet, Ruhr University Bochum, Bochum, Germany, 6AbbVie Inc., North Chicago, IL, 7AbbVie GK, Tokyo, Tokyo, Japan, 8Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan

    Background/Purpose: Risankizumab (RZB), an IL-23 p19 inhibitor, is well tolerated and provides long-term efficacy through 100 weeks in adults with PsA, demonstrated by the phase…
  • Abstract Number: 2581 • ACR Convergence 2024

    Vunakizumab in Patients with Active Psoriatic Arthritis: A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study

    Hejian Zou1, Weiguo Wan2, Yu Xue1, Lingyun Sun3, Ning Zhang4, Haiying Chen5, Xiaofei Shi6, Shengyun Liu7, Lin Chen8, Xinmei Ma9, Hua Wei10, Zhenyu Jiang11, Xiaomei Li12, Hongtao Fan13, Hongbin Li14, Jingyang Li15, Rui Wu16, Guixiu Shi17, Jing Zhu18, Xiaodan Kong19, Yuewu Lu20, Xiaojing Cui21, Qianning Zheng21, Xiaoyan Bai22 and Guangchao Dong21, 1Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China (People's Republic), 2Huashan Hospital, Fudan University, Shanghai, China (People's Republic), 3Dept of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing Univ Medical School, Nanjing, CN, Nanjing, China (People's Republic), 4Shengjing Hospital Affiliated to China Medical University, Shenyang, China (People's Republic), 5The Third Hospital of Hebei Medical University, Shijiazhuang, China (People's Republic), 6The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China (People's Republic), 7The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (People's Republic), 8Jilin Province People's Hospital, Changchun, China (People's Republic), 9Zaozhuang Municipal Hospital, Zaozhuang, China (People's Republic), 10Subei People's Hospital of Jiangsu Province, Yangzhou, China (People's Republic), 11The First Hospital of Jilin University, Changchun, China (People's Republic), 12The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China (People's Republic), 13The First People's Hospital of Yunnan Province, Kunming, China (People's Republic), 14Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China (People's Republic), 15Zhuzhou Central Hospital, Zhuzhou, China (People's Republic), 16The Tirst Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China (People's Republic), 17The First Affilated Hospital of Xiamen University, Xiamen, China (People's Republic), 18Sichuan Provincial People's Hospital, Chengdu, China (People's Republic), 19The Second Affiliated Hospital of Dalian Medical University, Dalian, China (People's Republic), 20BeiJing Chao-Yang Hospital, Capital Medical University, Beijing, China, 21Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China (People's Republic), 22Jiangsu Hengrui Pharmaceuticals Co., Ltd., Beijing, China

    Background/Purpose: Patients with psoriasis often develop psoriatic arthritis (PsA), a chronic systemic inflammatory disease with a severe clinical burden that impairs quality of life. In…
  • Abstract Number: 0074 • ACR Convergence 2024

    Tofacitinib Therapy Ameliorates Inflammation in a Mouse Model of Psoriasis and Arthritis by Inducing Type 2 Immunity

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Angel Rangel-Garcia1, Marissa Krantz3, Delaney Martino1, Marc Nuzzo1 and Christopher Ritchlin4, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3University of Rochester, Rochester, NY, 4Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Psoriatic arthritis (PsA), a chronic progressive inflammatory arthritis, affects peripheral joints and causes patient disability. PsA patients also have skin plaques initiated by activation…
  • Abstract Number: 2582 • ACR Convergence 2024

    Efficacy and Safety of Sonelokimab, a Novel IL-17A- and IL-17F-Inhibiting Nanobody, in Patients with Active PsA: 24-Week Results from a Global, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial

    Iain McInnes1, Laura Coates2, Philip Mease3, Alexis Ogdie4, Arthur Kavanaugh5, Lihi Eder6, Georg Schett7, Alan Kivitz8, Nuala Brennan9, Alex Godwood9, Eva Cullen9, Kristian Reich9, Christopher Ritchlin10 and Joseph F. Merola11, 1University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 2University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 3Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA, 4Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 5University of California San Diego, La Jolla, CA, 6University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8Altoona Center for Clinical Research, Duncansville, PA, 9MoonLake Immunotherapeutics AG, Zug, Switzerland, 10Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 11UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: Sonelokimab is a novel humanized Nanobody designed to inhibit IL-17A and IL-17F and penetrate clinically relevant sites of inflammation. The 24-week Phase 2 ARGO…
  • Abstract Number: 0278 • ACR Convergence 2024

    Efficacy and Safety of Genakumab versus Compound Betamethasone in Gout: The GUARD-1 Study

    Yu Xue1, Tianshu Chu2, Jiankang Hu3, Wei Gou4, Ning Zhang5, Juan Li6, Jing Yu7, Songping Li8, Songbin Li9, Long Qian10, Xinwang Duan11, Lihua Duan12 and Hejian Zou1, 1Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China (People's Republic), 2Department of Rheumatology, Henan Provincial People's Hospital, Zhengzhou, China, Zhengzhou, China (People's Republic), 3Department of Rheumatology, Pingxiang People's Hospital, Pingxiang, China, Pingxiang, China (People's Republic), 4Department of Rheumatology, Hebei Petro China Central Hospital, Langfang, China, Langfang, China (People's Republic), 5Department of Rheumatology, Shengjing Hospital of China Medical University, Shenyang, China, Shenyang, China (People's Republic), 6Department of Rheumatology, The First Affiliated Hospital of Hainan Medical University, Haikou, China, Haikou, China (People's Republic), 7Department of Rheumatology, The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China, Shenyang, China (People's Republic), 8Department of Rheumatology, The First Affiliated Hospital of Ganna Medical University, Ganzhou, China, Ganzhou, China (People's Republic), 9Department of Rheumatology, The First Hospital of Qiqihar, Qiqihar, China, Qiqihar, China (People's Republic), 10Department of Rheumatology, The Second Hopital of Anhui Medical University, Hefei, China, Hefei, China (People's Republic), 11Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, Nanchang, China (People's Republic), 12Department of Rheumatology, Jiangxi Provincial People's Hospital, Nanchang, China, Nanchang, China (People's Republic)

    Background/Purpose: The GUARD (Genakumab in high Uric Acid-induced Arthritis/goutfor Resolution and Delay study) program was designed to investigate the efficacy and safety of Genakumab, a…
  • Abstract Number: 2585 • ACR Convergence 2024

    Guselkumab and IL-17 Inhibitors Improve Patient-perceived Impact of Psoriatic Arthritis Similarly: 6-month Interim Results of the PsABIOnd Observational Cohort Study

    Stefan Siebert1, Mohamed Sharaf2, Carlo Selmi3, Proton Rahman4, Mitsumasa Kishimoto5, Enrique R. Soriano6, Emmanouil Rampakakis7, László Köleséri8, Minni Koivunen9, Frederic Lavie10, Ruben Queiro Silva11, Frank Behrens12, Ennio Lubrano13 and Laure Gossec14, 1School of Infection and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 2Johnson & Johnson, Middle East FZ LLC, Dubai, UAE, Dubai, United Arab Emirates, 3Department of Biomedical Sciences, Humanitas University, Rozzano, Italy, 4Memorial University of Newfoundland, Faculty of Medicine, Division of Rheumatology, St. John's, Canada, 5Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, 6Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 7McGill University, Department of Pediatrics / Scientific Affairs, JSS Medical Research Inc., Montreal, QC, Canada, 8Data Sciences Staffing Solutions, IQVIA, Inc, Budapest, Hungary, 9Janssen Cilag Oy, Espoo, Finland, Espoo, Finland, 10Janssen Cilag Global Medical Affairs, Immunology Global Medical Affairs, Issy les Moulineaux, France, 11Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Oviedo, Spain, 12University Hospital Goethe University Frankfurt and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt, Germany, 13Vincenzo Tiberio Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy, 14Sorbonne Université, Paris, France

    Background/Purpose: PsA leads to significant patient-perceived burden of disease. Targeted drugs have demonstrated efficacy in randomised controlled trials including in aspects of patient-reported impact. However,…
  • Abstract Number: 0303 • ACR Convergence 2024

    Phase 2b, Long-term Extension, Dose-ranging Study of Oral JNJ-77242113 for the Treatment of Moderate-to-Severe Plaque Psoriasis: FRONTIER-2

    Laura K. Ferris1, Jerry Bagel2, Yu-Huei Huang3, Andrew E. Pink4, Stephen K. Tyring5, Georgios Kokolakis6, Amy M. DeLozier7, Daniel Kakaley8, Shu Li9, Yaung-Kaung Shen10, Takayuki Ota7 and Robert Bissonnette11, 1University of Pittsburgh, Pittsburgh, PA, 2Psoriasis Treatment Center of Central NJ, East Windsor, NJ, 3Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taoyuan City, Taiwan (Republic of China), 4NHS Foundation Trust Great Maze Pond, London, United Kingdom, 5Center for Clinical Studies, Webster, TX, 6Psoriasis Research and Treatment Center, Department of Dermatology, Venereology and Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 7Janssen Research & Development, LLC, San Diego, CA, 8Janssen Scientific Affairs, LLC, Horsham, PA, 9Janssen Research & Development, LLC, Spring House, PA/San Diego, CA, 10Janssen Research & Development, LLC, Spring House, PA, 11Innovaderm Research, Montreal, QC, Canada

    Background/Purpose: JNJ-77242113, a targeted oral peptide, inhibits IL-23 signaling by binding the IL-23 receptor. At all doses, JNJ-77242113 showed superior efficacy at Week 16 versus…
  • Abstract Number: 2597 • ACR Convergence 2024

    The Stromal-cell Derived Cytokine interleukin-17D Attenuates Joint Inflammation

    Jia (Sijia) Chen1, Roopa Madhu2, Catherine Manning3, Daniel Montoro4, Nataliya Yeremenko5, Kevin Wei6, ilya Korsunsky1, Dominique Baeten5 and Ellen Gravallese7, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Brookline, MA, 3Brigham and Women's Hospital, Dedham, MA, 4TenSixty Biosciences, Boston, MA, 5Amsterdam University Medical Centers, Amsterdam, Netherlands, 6Brigham and Women's Hospital at Harvard Medical School, Boston, MA, 7Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: The interleukin-17 (IL-17) family of cytokines consists of 6 evolutionarily conserved cytokines, IL-17A-F. Of these, IL-17A, B, C, and F play diverse roles in…
  • Abstract Number: 0562 • ACR Convergence 2024

    Serum Interleukin IL-40 as a Potential Biomarker Associated with Pro-inflammatory Activity in Inflammatory Bowel Diseases and Spondyloarthritis: A Preliminary Study

    Lucia Ondrejčáková1, Adéla Navrátilová2, Monika Gregová3, Kristýna Bubová4, Tomáš Grega5, Ladislav Šenolt6, Karel Pavelka7 and Lucie Andrés Cerezo8, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 21st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine Charles University, Prague, Czech Republic, 4Institute of Rheumatology and Charles University, Prague, Czech Republic, 53Department of Internal Medicine, First Faculty of Medicine, Charles University, Military University Hospital, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7Institute of Rheumatology and Charles University, Praha, Czech Republic, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Interleukin 40 (IL-40) is a novel cytokine with a proposed role in the pathogenesis of inflammatory diseases. Inflammatory bowel diseases (IBD)-associated with spondyloarthritis (SpA)…
  • Abstract Number: 2616 • ACR Convergence 2024

    Associations of Circulating Inflammatory Cytokines with Long COVID Among Patients with Systemic Autoimmune Rheumatic Diseases

    Jeffrey Sparks1, Xiaosong Wang2, Pui Lee3, Kailey Brodeur4, Miao Lin5, Naomi Patel5, Yumeko Kawano6, Abigail Schiff7, Andrew King5, Jennifer Hanberg6, Shruthi Srivatsan5, Emily Kowalski6, Colebrook Johnson5, Kathleen Vanni6, Zachary Williams5, Grace Qian2, Caleb Bolden5, Kevin Mueller6, Katarina Bade6, Alene Saavedra6, Rathnam Venkat8 and Zachary Wallace9, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Boston Children's Hospital, Newton, MA, 4Boston Children's Hospital, Cumberland, RI, 5Massachusetts General Hospital, Boston, MA, 6Brigham and Women's Hospital, Boston, MA, 7Brigham and Women's Hospital, Cambridge, MA, 8Tufts University School of Medicine, Boston, MA, 9Massachusetts General Hospital, Newton, MA

    Background/Purpose: While the incidence of severe acute COVID-19 has decreased, post-acute sequelae of COVID-19 characterized by prolonged symptoms, or ‘long COVID,’ is common and associated…
  • Abstract Number: 0585 • ACR Convergence 2024

    Cycling to TNFi vs. Switching to IL-17Ai After a First TNFi Discontinuation Among Patients with PsA and axSpA: The CorEvitas PsA/SpA Registry

    Alexis Ogdie1, Nicole Middaugh2, Maya Marchese2, Jessica A Walsh3, Natalia Bello4, Jeffrey Lisse4, Andris Kronbergs5, Elsie Grace6, Marcus Ngantcha4 and Philip Mease7, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2CorEvitas, LLC, Waltham, MA, 3Division of Rheumatology, Salt Lake City Veterans Affairs Health and University of Utah Health, Salt Lake City, UT, 4Eli Lilly and Company, Indianapolis, IN, 5Eli Lilly, Indianapolis, IN, 6Eli Lilly and Company, Indianapolis, 7Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Treatment guidelines recommend tumor necrosis factor inhibitors (TNFi) and interleukin-17A inhibitors (IL-17Ai) as options for patients with PsA or axSpA with persistent disease activity…
  • Abstract Number: 2646 • ACR Convergence 2024

    Rare Variants in the IL1RAP Gene Implicate the IL-1 Signaling Pathway in the Pathogenesis of Systemic Sclerosis in African and European Ancestries

    Yosuke Kunishita1, Urvashi Kaundal2, Martin Kerick3, Ryan Routsong4, Justin Lack4, Ami Shah5, Maureen Mayes6, Daniel Shriner7, Ayo P. Doumatey7, Amy Bentley7, Robyn Domsic8, Thomas Medsger, Jr9, Paula Ramos10, Richard Silver11, Virginia Steen12, John Varga13, Vivien Hsu14, Lesley Ann Saketkoo15, Dinesh Khanna13, Elena Schiopu16, Jessica Gordon17, Lindsey Criswell18, Heather Gladue19, Chris Derk20, Elana Bernstein21, S. Louis Bridges17, Victoria Shanmugam22, Lorinda Chung23, Suzanne Kafaja24, Reem Jan25, Marcin Trojanowski26, Avram Goldberg27, Benjamin Korman28, James W. Thomas29, Elaine Remmers30, Adebowale Adeyemo7, Charles Rotimi7, Fredrick Wigley31, Francesco Boin32, Javier Martin3, Daniel Kastner33 and Pravitt Gourh34, 1Scleroderma Genomics and Health Disparities Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Scleroderma Genomics and Health Disparities Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Chevy Chase, MD, 3Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Spain, Granada, Spain, 4Integrated Data Sciences Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 5Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 6UTHealth Houston Division of Rheumatology, Houston, TX, 7Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 8Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 9Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, 10Medical University of South Carolina, Charleston, SC, 11Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 12Georgetown University School of Medicine, Washington, DC, 13University of Michigan, Ann Arbor, MI, 14Department of Medicine, Rheumatology Division, Rutgers-RWJ Medical School, South Plainfield, NJ, 15New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University and Tulane University Medical Schools, New Orleans, LA, 16Division of Rheumatology, Medical College of Georgia at Augusta University, Martinez, GA, 17Division of Rheumatology, Weill Cornell Medical College, New York, NY, 18Genomics of Autoimmune Rheumatic Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Bethesda, MD, 19Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 20Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 21Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 22Office of Autoimmune Disease Research, Office of Research on Women's Health, National Institutes of Health, Great Falls, VA, 23Stanford University, Woodside, CA, 24Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 25Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, 26Department of Rheumatology, Boston University School of Medicine, Boston, MA, 27NYU Langone Health - NYU Hospital for Joint Diseases, Lake Success, NY, 28University of Rochester, Rochester, NY, 29NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 30Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 31Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, 32Cedars-Sinai Medical Center, Los Angeles, CA, 33National Human Genome Research Institute, Bethesda, MD, 34National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by systemic inflammation and fibrosis. Interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor for the Interleukin-1…
  • Abstract Number: 0605 • ACR Convergence 2024

    Guselkumab Binding to CD64+ IL-23–Producing Myeloid Cells Enhances Potency for Neutralizing IL-23 Signaling

    Dennis McGonagle1, Raja Atreya2, Maria Abreu3, James Krueger4, Kilian Eyerich5, Robert Bissonnette6, Carrie Greving7, He Li8, Tom C. Freeman9, Amy Hart8, Brice Keyes7, Brian Stoveken8, John Hartman8, Kristin Leppard8, Jenna Parrett10, Joshua Wertheimer8, Indra Sarabia7, Janise Deming7, Kristen Kohler7, Christopher Ritchlin11, Iain McInnes12, Matthieu Allez13, Anne Fourie7 and Kacey Sachen7, 1National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds Teaching Hospitals, Leeds, UK, Leeds, England, United Kingdom, 2Department of Medicine I, Gastroenterology, Endocrinology and Pneumology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 3Leonard M. Miller School of Medicine, University of Miami, Miami, FL, 4The Rockefeller University, Laboratory for Investigative Dermatology, New York, NY, 5Karolinska Institute, Department of Medicine – Division of Dermatology and Venereology, Stockholm, Sweden; Medical Center, University of Freiburg, Freiburg, Germany, 6Innovaderm Research Inc., Montréal, QC, Canada, 7Janssen Research & Development, LLC, Immunology, San Diego, CA, 8Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 9Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 10Janssen Scientific Affairs, LLC, Horsham, PA, 11Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY, 12University of Glasgow, College of Medical Veterinary and Life Sciences, Glasgow, United Kingdom, 13Hôpital Saint-Louis, Université Paris Cité, Paris, France

    Background/Purpose: IL-23 is implicated in the pathogenesis of psoriasis (PsO), and myeloid cells that express FcγRI (CD64) have been identified as a primary source of…
  • Abstract Number: 0606 • ACR Convergence 2024

    Choice of Biologic Immunotherapy for Psoriasis or Psoriatic Arthritis Not Associated with Risk of Major Adverse Cardiac Events

    Bonit Gill1, Jack Geiger1, Jean Liew2, Michael Putman3 and Shikha Singla1, 1Medical College of Wisconsin, Milwaukee, WI, 2Boston University, Boston, MA, 3The Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Individuals with psoriasis or psoriatic arthritis (PsO/PsA) have an elevated risk ofmajor adverse cardiac events (MACE), which include congestive heart failure (CHF), myocardialinfarction (MI),…
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